Search PubMed⌕ Search

Biomedical subjects

A Bohle

Publications and source records attributed to A Bohle.

At least 145 records · Page 8Linked to original sources
PubMed1975

The glomerular mesangium in hypertension: a morphometrical comparison of nephrosclerosis with mesangioproliferative glomerulonephritis on renal biopsies.

Glomerular changes were morphometrically studied in renal biopsies of 27 cases of nephrosclerosis showing clinically benign or malignant hypertension and of 15 cases of mild mesangioproliferative glomerulonephritis with hypertension. In nephrosclerosis, there was a mild increase in mesangial matrix without cell proliferation. The degree of the mesangial changes varied little despite a large variation in blood pressure and showed no significant difference between benign and malignant hypertension. In mild mesangioproliferative nephritis with hypertension, mesangial matrix, as well as the number of mesangial cells, showed an increase of varying degree. A quantitative assessment of the mesangium was proved effective in differentiating the glomerular changes in nephrosclerosis from those in mesangioproliferative nephritis with hypertension.

Adult↗
PubMed1975

The immunological significance of cellular infiltrates in chronic rejection of human kidney transplants.

Fifteen transplanted human kidneys with clinical and histological signs of chronic rejection were examined microscopically for cellular infiltration. Three normal kidneys were used as a reference. All infiltrating cells were classified and counted. The average number of cells per 10 microscopic fields was called the relative density of cellular infiltrates. Differences in the densities of different cell classes and changes in the cellular infiltration of the grafts were regarded as cellular expressions of the immune response. Summarizing our results, we conclude that: 1) the chronic immunological rejection of transplanted human kidneys is essentially caused by immunocompetent cells; 2) plasma cells develop in the graft itself; 3) the immunocompetent cell population tends to be purely and simply made up of plasma cells; 4) therefore, the true "effector cell" among the immunocompetent cells may be the plasma cell--at least in the chronic rejection of transplanted human kidneys. Cleaved lymphocytes were the most frequent of the infiltrating cells found in the transplants. However, their role is not yet clear.

Cell Count↗
PubMed1975

[Perimembranous glomerulonephritis after treatment with D-penicillamine. Report on 31 cases (author's transl)].

This report includes 31 patients who developed a perimembranous glomerulonephritis generally 7 months after the onset of the treatment of various illnesses with D-Penicillamine. In all cases the patients had a proteinuria, associated with a hematuria in 12 cases. After the treatment was stopped 8 patients rapidly developed a nephrotic syndrome, while its onset was more gradual in 12 other patients. 5 patients initially with a nephrotic syndrome had no proteinuria at the time of a second biopsy made up to 12 months later. In these 5 cases the typical changes of perimembranous glomerulonephritis observed on electron microscopy were much reduced in the second biopsy.

Adolescent↗
PubMed1975

The structure of the human juxtaglomerular apparatus. A morphometric, lightmicroscopic study on serial sections.

49 juxtaglomerular apparatuses were examined using 1.9mu thick Giemsa-stained serial sections from human renal tissue embedded in plexiglass. In 43 juxtaglomerular apparatus the direct contact areas between the different juxtaglomerular structures and the basal area of the macula densa were calculated. A positive, significant correlation was found between the size of the macula densa and the direct contact area between macula densa and Goormaghtigh's cell field on the one hand, and between the macula densa and the direct contact area between Goormaghtigh's cell field and the afferent arteriole on the other. There was also a significant, positive correlation between the direct contact area of Goormaghtigh's cell field with the macula densa and that of Goormaghtigh's cell field with the afferent arteriole. On the efferent side none of these correlations were significant. Thus a "flow of information" from the macula densa via the Goormaghtigh cells to the afferent arteriole is morphologically possible. The direct contact areas between macula densa and the afferent or the efferent arterioles were not correlated with any of the other parameters. Epithelioid cells were present in the interlobular arteries, prior to and within the juxtaglomerular apparatus in the afferent arterioles, as well as within and beyond the juxtaglomerular apparatus in the efferent arterioles.

Adult↗