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Biomedical subjects

A Blanco

Publications and source records attributed to A Blanco.

At least 271 records · Page 15Linked to original sources
PubMedDate not supplied

[Pathogenic considerations in systemic lupus erythematosus D.L.E. immunohistologic studies (author's transl)].

Immunohistochemical studies in the gust, skin and kidney of a systemic lupus erythematosus patient are presented. The results suggest that there is no digestive participation in the immunologic disturbances that the vascular and glomerular depositions are independent and that antibodies are present in the dermoepidermal junction which class is different and it does not correlate with circulating antinuclear antibodies.

Child↗
PubMedDate not supplied

[Allergy to animal hair. Cutaneous manifestations (author's transl)].

The authors report 25 cases of allergy to animal hair in childhood. 13 patients were polisensitized, and in the remaining 12 hair was the only allergen responsible for the clinical picture. The main clinical features are discussed and the high incidence of atopic cutaneous signs pointed out. In three patients these were the only clinical manifestation. Desensitization was successful, although this is, difficult to undertake without a substantial modification of the surrounding environment.

Adolescent↗
PubMedDate not supplied

[Modifications of phosphocalcic metabolism in patients treated with anticonvulsivants (author's transl)].

Differences in the seric values of Ca, P and alk. phosphatase before and after 12 to 18 months of anticonvulsant therapy in 45 patients are reported. They were significant for alk. phosphatase in patients under either barbiturates or barbiturates associated with hydantoin. For calcium they were significant in patients treated with barbiturate plus hydantoins and either one of these plus other drugs. It is assumed that supplementary vitamin D can be necessary in these group of patients.

Alkaline Phosphatase↗
PubMedDate not supplied

[Corticosteroids in viral hepatitis (author's transl)].

138 cases of viral hepatitis were selected among 27,000 pediatric clinical records corresponding to the years 1965-75. The clinical course of patients receiving corticosteroids during the acute phase was compared to that of the remaining patients, and an increased number of prolonged course cases was observed. At the same time, more frequent evolution to either aggressive forms or cirrhosis is suggested. Therefore, the authors discourage the use of corticosteroids in the treatment of common viral hepatitis.

Adolescent↗
PubMedDate not supplied

[Tumors in newborn infants].

Fifty one cases of tumors detected along a 20 years period (1969 throughout 1989) in newborn infants are described. Most frequent kinds of neonatal tumors were teratomas (n: 30), followed by vascular tumors (n: 6), neuroblastomas IV-S (n: 5), hepatic hamartomas (n: 5), renal tumors (n: 3), soft tissue sarcomas (n: 2) and melanocytic melanoma (n: 1). Follow up was extended from 1 to 20 years. Death occurred in two patients of this series: one in a case of sacrococcygeal teratoma, who died of septicemia secondary to urinary tract obstruction and infection before any attempt of surgical treatment was possible, and by multiple pulmonary metastases one year after apparently satisfactory surgical treatment in another patient with neuroblastoma.

Chile↗
PubMedDate not supplied

[Ultrasonographic diagnosis of hypertrophic pyloric stenosis].

Hypertrophic pyloric stenosis (HPS) is one of the most common causes of abdominal surgery during the first weeks of life. The primary cause of the muscular hypertrophy is unknown and the pathogenesis is obscure. Clinically, vomiting is always present and sometimes there is a palpable pyloric mass (olive). Upper gastrointestinal tract study with barium has been the most usual method for the diagnosis. Since the first report of the use of ultrasound (US) in the diagnosis of HPS in 1977, this technique has been widely used and accepted, being by now, the diagnostic imaging examination of choice for infants in whom this abnormality is suspected. This is our experience with the use of US in 27 infants with clinically suspected HPS. In 17 cases there was US evidence of HPS and in 10 patients results were negative. We did not have false positive neither false negative results. We strongly recommend this diagnostic method for all infants under clinical suspicion of HPS.

Female↗
PubMedDate not supplied

IgA1, IgA2 or secretory piece containing antigliadin antibodies in the sera of coeliac patients.

A study was made of the gliadin antibodies containing secretory piece (SP) found in 73 sera samples obtained from 38 children with coeliac disease (CD); simultaneously an intestinal biopsy was carried out. In 32 cases the mucosa was flat and the remaining 41, following a gluten-free diet, had a normal intestinal histology. Thirty chronic non-coeliac gastrointestinal patients and 22 normal children were used for a control. An enzymoimmunoassay technique with monoclonal IgA1 and IgA2, and SP polyclonal antibodies was used. The antigliadin antibodies containing SP in serum were above normal limits in 24/32 (75%) active CD patients, but also in 22/41 (54%) patients with normal biopsy and in 20/30 (66%) chronic non-coeliac gastrointestinal patients. There was a multivariant correlation (p less than 0.002) among antigliadin, ovoalbumin and lactoglobulin antibodies containing SP. These results are probably due to non-specific intestinal damage. Nevertheless, antigliadin antibodies containing SP in the sera of gluten-free CD cases lasted longer than antiovoalbumin and antilactoglobulin antibodies. The IgA1 antigliadin antibodies were increased in 19/30 (64%) of active CD patients and 0/8 of inactive CD patients (p less than 0.0005). Nevertheless IgA2 antibodies were increased in only 2/30 (7%) of active CD patients (p less than 0.05). According to this study the IgA antigliadin antibodies in serum are the result of a systemic response, although another interpretation could be that gliadin mainly stimulates IgA1 subclass antibodies in the gut.

Antibodies↗
PubMedDate not supplied

Transient phenytoin induced IgA deficiency and permanent IgE increase.

This is a report of a 9-year-old epileptic boy, who was studied over a period of 7 years. The seizures started when he was 2 months old. He was treated with phenytoin from the age of 2 years and 7 months. Serum and salivary IgA were absent with high IgE serum total. The routine immunologic studies were normal. The IgA was normalized after phenytoin withdrawal, but IgE determination increased progressively without any atopic symptoms. The T4 (helper)/T8 (suppressor) ratio decreased (1.0 and 1.2) on two different days, although above the normal limit. The phenytoin only modified the IgA levels. These data suggest that a primary immunoregulatory abnormality may be present in drug induced IgA deficiency.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

C1q-binding immune complexes and other immunological studies in children with pulmonary hemosiderosis.

We report immunological studies performed in 19 sera from 4 children with idiopathic pulmonary hemosiderosis (IPH). Circulating C1q binding immune complexes (IC) were found in 3/4 of the patients during the acute phase. One child showed IC in 4 consecutive crises but they disappeared very rapidly (within 36 hours). Only one serum was positive after acute crisis. In one patient who had 2 episodes. IC were never detected. Precipitation with 2% polyethylene glycol did not correlate with the C1q binding assay. Pulmonary biopsy was available in just one patient and neither immunoglobulins nor complement were found by immunofluorescence. IgA, IgM, IgE, C4 or B factor abnormalities were only occasionally seen. Antinuclear, anti-reticulin and anti-alveolar basement membrane antibody test were always negative. Precipitins against cow's milk proteins were not detected. Seric IC could be primary or secondary to macrophage blockade by hemosiderin. Even in this case, it is well known that circulating IC can perform some immunological actions by interacting with cell receptors or releasing active mediators. In the future, the possibility that IC could contribute to IPH pathogenesis, or modify the treatment response must be taken into account.

Antigen-Antibody Complex↗
PubMedDate not supplied

[Incidence of circulating immune complexes in pediatric diseases. Comparative study with adults].

Circulating immune complexes were studied using 3.5% polyethyleneglycol precipitation in 312 children with various diseases whose ages ranged from 1 month to 14 years. One hundred and one patients (32.6%) were positive and the groups with the highest percentage were those with viral hepatitis (90%), sepsis (80.7%), collagen diseases (76.4%) and Schonlein-Henoch purpura (57.1%). We found immune complexes less frequently in idiopathic thrombocytopenic purpura than in published series of adult cases, possibly due to the fact that the diseases in children is due to a different pathogenetic mechanism. The composition of the immune complexes was tested by 1% agarose immunodiffusion against a panel of antisera. IgG and IgM were found most frequently, and IgA was very uncommon except in some cases of hepatitis. C4 was the most frequently found complement component, followed by C3. Important differences between the various diseases studied were noted. Our results are very similar to those previously published by other authors. Whereas serum autoantibodies and autoimmune diseases are less common in children than in adults, circulating immune complexes seem to have a similar frequency in children to that already reported for adults. It is difficult to assess the significance of circulating immune complexes. They might be (a) a mere "marker" of no pathogenic significance (b) a mechanism of tissue damage by intravascular deposition, or (c) they might interfere with the cell membrane receptors of macrophages, producing a defect in phagocytosis. However, we were unable to demonstrate an increased number of infections in these patients.

Adolescent↗
PubMedDate not supplied

Hemorrhagic enteritis by adenovirus-like particles in turkeys: a possible pathogenic mechanism.

This paper describes an outbreak of hemorrhagic enteritis due to adenovirus in turkeys in Spain. Diagnosis of the disease was confirmed by histopathological examination and the observation of adenovirus in spleen mononuclear cells and intestinal infiltrate. Evidence was also found of intravascular coagulation, which may give rise to the bleeding considered characteristic of this disease.

Adenoviridae Infections↗