The electrical activity of the heart and brain under acute experimental anoxia: the protective effect of polarizing solutions.
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Biomedical subjects
Publications and source records attributed to A Bisteni.
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On an experimental basis the authors studied the process of repolarization and depolarization in high frequency electrocardiograms of 30 healthy children. The negativity of the T wave in V1 and V2 corresponds with the repolarization of the left ventricle and the positivity with that of the right ventricle. The vectors of repolarization of both ventricles were identified and found to be situated on a horizontal plane. In all tracings the electrical systole of the right ventricle was found to be greater than that of the left ventricle. The number of components of high frequency tracings in the intrinsecoid deflexion was greater on the right ventricle. The authors suggest that the high frequency electrocardiogram is a valuable procedure in clinical investigation.
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Several haemodynamic and biochemical parameters were studied in order to explain the diagnostic value of the electrocardiographic abnormalities in partial myocardial diastolic depolarization, in different conditions, as experimental coronary oclussion, adrenalinic effects, tachycardia, hypoxia and shock. It is concluded that the electrocardiographic signs of diastolic depolarization (injury tissue) are: RS-T deplacement, conduction disturbances at bundle, fascicular and muscular levels, as well as ventricular ectopic beats. The experimental findings were correlated with clinical cases showing electrocardiographic signs of ventricular diastolic depolarization, as in myocardial infarct, angina pectoris, hypertensive heart disease, pheocromocitoma and tachycardia. It is concluded that the oxygen volume available at mitochondrial level is diminished, if it is correlated to the metabolic and/or haemodynamic alterations.
The High-Frequency ECG was studied in 78 patients with systemic arterial hypertension and in 10 normal subjects. The study has shown: a) the P wave is altered initially, according to the disturbances in the myocardial complicance; b) the signs of LVH are mainly: delayed in the appearance of the intrinsecoid deflection, abnormal left direction of vector 3, left electrical systole diminished and counter clockwise rotation; c) the exhaustion fase is represented by increased of the electrical systole, delay in the duration of the intrinsecoid deflection and by primary disturbances of repolarization. The relationships between the ECG and the hymodynamic and metabolic disturbances, are discussed.
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The electrical consequences of experimental acute myocardial ischemia were studied in 50 dogs. The study was performed through unipolar epicardial leads and at different levels of the conducting system; bundle branch and Purkinje fibers. There is evidence that the block takes place at the Purkinje-muscle union or in the muscle-muscle conduction. In none of the experiments the block appeared in any of the components of the conducting system. Also, there is evidence that with severe ischemia muscle recordings disappeared while the Purkinje potentials remained unchanged, this suggests that conducting system cells are more resistant to hypoxia than the contractile cells. Ventricular arrhythmias usually appeared simultaneously with conduction blocks that favored reentries. Arrhythmias were more frequent when the blocks were more accentuated. Our data demonstrates that the conduction disorder precedes in some instances, the positive RS-T displacement and in others it hides the such displacement. It is concluded that the RS-T displacement, the distal conduction block and arrhythmias are manifestations, at different levels, of partial diastolic depolarization induced by acute myocardial ischemia.
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