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Biomedical subjects

A Bini

Publications and source records attributed to A Bini.

At least 91 records · Page 5Linked to original sources
PubMed1980

Intermittent heparin treatment does not induce hypercoagulability in haemodialysed patients.

Antithrombin-III (AT-III) and factor VIII coagulant (F VIII:C) and antigenic (F VIII:RA) activities have been studied in nine conservatively treated and 26 dialysed uraemic patients. AT-III levels were not significantly different from those of controls in either group. Among dialysed patients, those who had experienced thrombotic occlusions of the vascular accesses could not be distinguished from the remaining patients on the basis of their AT-III levels. Both F VIII:C and F VIII:RA were slightly higher than in controls in conservatively treated patients, but significantly higher in haemodialysed patients, especially in those who had never experienced thrombotic complications of the vascular accesses. No acute changes were observed in either the AT-III or F VIII:C/F VIII:RA ratio in five patients given heparin therapy during a dialytic session or in the interdialytic period. Thus repeated intermittent heparin treatment does not induce a hypercoagulable state in haemodialysed patients.

Adult↗
PubMed1980

Ultrastructural and biochemical changes induced by progressive lipid peroxidation on isolated microsomes and rat liver endoplasmic reticulum.

Ultrastructural and biochemical alterations induced by progressive lipid peroxidation on rat liver endoplasmic reticulum and on isolated microsomes have been studied. Lipid peroxidation was followed by measuring the content of malonaldehyde and similar thiobarbituric acid-reacting substances in the control specimens and in specimens in which lipid peroxidation was stimulated by CCl4 or other prooxidant systems. Lipid peroxidation induced a remarkable decrease in aminopyrine demethylase activity and in the cytochrome P-450 content both in vivo and in vitro. Parallel to these observations, alterations in the assembly of the membranes of isolated rat liver microsomes and of in situ endoplasmic reticulum were followed by electron spin resonance and electron microscopy. Electron spin resonance revealed changes in the resonance spectra interpreted as solubilization of cytochrome P-450 from the membrane. Electron microscopy on fixed and sectioned, negatively stained and freeze-fractured specimens revealed membrane alterations that were progressive with time of peroxidation. These alterations consisted of: (1) increased membrane deformability; (2) local and progressive breakages on the membranes; and (3) loss of intramembranous particles on both fracture faces of the membranes. The results obtained with the different techniques are compared and discussed in light of the importance of the lipid environment for the structure and function of biologic membranes.

Aminopyrine N-Demethylase↗
PubMed1979

Platelet aggregation and antithrombin III levels in diabetic children.

We studied platelet function and antithrombrin III levels in 30 insulin-dependent diabetic children with no clinically evident vascular complications. 9 were in-patients and 21 were out-patients. The disease had been discovered within the previous 10 years. 25 control subjects of comparable age and body weight were studied simultaneously. Template bleeding time, threshold concentrations of ADP or adrenaline required to induce irreversible platelet aggregation and plasma antiherparin activity (platelet factor 4) did not differ significantly in control and patient groups. In contrast, the immunological levels of plasma antithrombine III were significantly higher in the diabetic group. These results suggest that diabetic children, with no clinical signs of microanigopathy, show no laboratory changes suggesting increased platelet function. The unxpected increase in the antithrombin III level could reflect a very early defense mechanism against activation of the blood clotting system.

Adenosine Diphosphate↗
PubMed1977

[Diagnostic problems of simple and complicated Meckel's diverticulum in adults].

The literature data concerning the incidence of Meckel's diverticulum in the adult and the frequency of its complications are examined and problems associated with the preoperative diagnosis of this form are discussed. Reference is made to the limitations of abdominal scintiscanning and the encouraging results obtained with superior mesenteric arteriography in diverticular bleeding. Five cases of Meckel's diverticulum in the adult are presented. Stress is placed on the need to explore the ileum during appendicectomy to enable diverticula to be detected and removed, since they are often the cause or the site of complications, even in the adult.

Adult↗
PubMed1977

[Behavior of some liver enzyme activities in newborn infants with jaundice treated with phototherapy].

The recent hypothesis that phototherapy is capable of altering the liver cell, enough to allow passive diffusion of free bilirubin from the blood to the bile, and the discovery of substantial differences between the breakdown products of bilirubin obtained in vivo and in vitro, has prompted the AA. to investigate the enzymatic values in newborn infants with jaundice undergoing phototherapy. A study was made of the variations of cytolithic enzymes (GPT-GOT-GLDH-SDH) and secretions enzymes (FA-LAP-gammaGT-CHE) before and after phototherapy among different sized groups of infants with jaundice, between the 36th and 40th week of the gestational age, and with body weight varying from 1940 to 4150 g. No significant alteration of the cytolithic enzymes were recorded and among the secretion enzymes only the gammaGT was seen to increase. According to the AA., phototherapy does not alter the presence of a possible transitory cholestasis in newborn infants with physiological jaundice and causes no significant damage to the liver cells.

Alanine Transaminase↗
PubMed1976

Immunologic cross-reactivity of antigen(s) induced by drug treatment in two leukemic sublines.

Previous studies have demonstrated that new antigenic specificities, not detectable on parental cells, can be induced by in vivo treatment of murine leukemic cells with anti-neoplastic agents. The immunologic properties of leukemic cells altered by treatment with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DIC) were investigated further. Immunologic cross-reactivity between two DIC-treated leukemic sublines has been demonstrated by cell-mediated immunity in vitro and by active or adoptive immunity in vivo. Rabbit antiserum to DIC-treated sublines absorbed with the parental cells showed residual activity against the DIC-sublines that was specifically inhibited by further absorption with DIC-cells.

Animals↗