Biomedical subjects
Publications and source records attributed to A Bianco.
Personal experience in the treatment of acquired valvulopathies and biliary calculosis in one operating stage is reported. After examination the risk factors determining onset of bile calculosis in valvulopathic patients, the surgical techniques adopted and the special advantages obtained by associating the two operations at the same session are illustrated.
Unanesthesized male Sprague-Dawley rats, averaging 261 g of weight (s.d. = 9 g), were exposed to a radioactively (198Au) labeled monodisperse carnauba wax aerosol, whose AMMD was 0.54 micrometers with a sigma g of 1.1, to determined the alveolar deposition and clearance of particles. Results indicate that 74% of the initial lung burden is cleared in phase one with a T/2 of 11 hours. The remaining 26%, conventionally considered to be the alveolar deposit, is cleared with a T22 of 320 hours. Excised lungs from serial sacrifices have also been measured. The retention curve resulting form the pooled lung data per each day compared well with the curve of the whole animals counted in vivo.
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A patient with a late recurrence (13 years) of Wilms tumor is presented. After relapse with conventional chemotherapy, an objective partial remission was obtained with bleomycin, vinblastine, cyclophosphamide, and cis-platinum. Stable disease was noted when bleomycin was withheld. Bleomycin in this combination appeared to effect a good response, and further studies of chemotherapy of Wilms tumor should include bleomycin in combination with other active agents.
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20 subjects with severe hepatic failure have been studied by means of all night polygraphic sleep recordings. Base night recordings have been made, as well as registrations after treatment with drugs that are known to improve the clinical conditions of these patients, especially concerning the psychic performances. Base night recordings show sleep disruption, with a large amount of wakefulness at the beginning of the registrations and during the night itself; sleep stages are strongly reduced, especially REM sleep. After L-dopa treatment, these negative patterns are furthermore enhanced and the percentage incidence of the REM stage is very low; nevertheless, this behaviour goes side by side with a light improvement in psychological performances. On the contrary, therapy with lactulose seems to improve the neuropsychiatric state and the sleep organization; as a matter of fact, wakefulness is lower in the night records after lactulose treatment, whilst the percentage incidence of sleep stages tends back toward normality; REM sleep has clearly risen.
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