Search PubMed⌕ Search

Biomedical subjects

A Bernabei

Publications and source records attributed to A Bernabei.

27 records · Page 2Linked to original sources
PubMed1977

Spontaneous length of depression and response to ECT.

Electro-convulsive treatment (ECT) was therapeutically ineffective in 27 (20%) of 136 depressed patients. Failure to respond occurred in long-lasting depressions and in patients with a history of long-lasting depressions. In these cases the depression lasted at least 6 months. The hypothesis is proposed that ECT is effective only when given within 6 months of thespontaneous end of the depression. Clinical and nosological implications are discussed.

Adult↗
PubMedDate not supplied

[Eruption cyst].

Explore the source record for details and available documents.

Child↗
PubMedDate not supplied

[Psychiatric aspects in workers subject to mobbing].

BACKGROUND: Mobbing in the language of ethologists means a particular behaviour of a group of animals consisting of several members forming an alliance against a single animal, in order to eliminate this animal away from the group. This term has been adopted in current usage to mean a kind of relationship at the workplace that, by aggressive and underhand means, aims at influencing or expelling the person. The term "bossing" is used to indicate a negative action, under the meaning described above, made by one or more senior persons, or possibly by the employer. In the Italian Parliament, under the current legislature, several bills are pending regarding this problem. Besides the aspects of topical interest in the problem, there are first and foremost the different kinds of reaction-adaptation to mobbing, according to the type of individual internal working models in action, that can be anxious/avoiding, anxious/resistant or disorganised. OBJECTIVES: The purpose of our study was a clinical evaluation of the different ways of adaptation-reaction to a mobbing-type relationship at the workplace, and of the type of internal working models found among the examined patients. METHODS: A clinical interview was carried out with 40 patients who, over a period of 12 months of observation, came to request a clinical assessment, for medical-legal reasons, of their psycho-pathological state and ways to react to adverse situations at the workplace, such as a mobbing or bossing. RESULTS: Besides the psychological and relational effects of mobbing, the reactions of the examined subjects to mobbing are also described, considering also the different cognitive self-organization possibilities, according to the individual internal working model, regarding patterns of attachment in adult age. The most frequent internal working model seems to be the one related to resistant attachment, followed by the avoidance and lastly--rarely--the disorganized model. Furthermore we observed among these subjects a certain deficit in meta-cognitive capacity of self reflection and decentralization. CONCLUSIONS: Cognitive therapy is proposed as the most effective of therapeutic approaches, associated with symptomatic psycho-pharmacological therapy as needed. Initial clinical results on cognitive therapy of these patients are reported. The individual type of internal working model seems to be the critical element in mobbing reaction and, besides specific intervention plans regarding relationship in the workplace, individual psychotherapy appears to be the best instrument of treatment and prevention of the psychopathologic effects caused by mobbing.

Adult↗
PubMedDate not supplied

[Implementation of a computerized pharmacological database for pediatric use].

The authors present a pharmacological database to support teaching and care activity carried out in the Divisional Paediatric Ambulatory of the Catholic University of Rome. This database is included in a integrated system, ARPIA (Ambulatory and Research in Pediatric by Information Assistance), devoted to manage ambulatory paediatric data. ARPIA has been implemented by using a relational DBMS, very cheap and highly diffused on personal computers. The database specifies: active ingredient and code number related to it, clinical uses, doses, contra-indications and precautions, adverse effects, besides the possible wrapping available on the market. All this is showed on a single for that appears on the screen and allows a fast reading of the most important elements characterizing every drug. The search of the included drugs can be made on the basis of three different detailed lists: active ingredient, proprietary preparation and clinical use. It is, besides, possible to have a complete report about the drugs requested by the user. This system allows the user, without modifying the program, to interact with the included data modifying each element of the form. In the system there is also a fast consultation handbook containing for every active ingredient, the complete list of italian proprietary medicines. This system aims to give a better knowledge of the most commonly used drugs, not only limited to the paediatrician but also to the ambulatory health staff; an improvement of the therapy furthering, a more effective use of several pharmacological agents and first of all a training device not only to specialists but also to students.

Child↗
PubMedDate not supplied

[Opioid mechanisms for modulating pain: descending pathways. Critical review].

This paper presents an extensive review of contributions on opiate controlled descending projections modulating analgesia. While there is a quite definite agreement on the organisation and structure of these projections, their true physiological role remains quite dubious. The hypothesis so far formulated on the modalities of activation of these circuits apparently don't hold a critical re-examination.

Animals↗
PubMedDate not supplied

Bilateral temporal lobectomy for late radionecrosis after radiotherapy for acromegaly. A case report.

A patient with right temporal radionecrosis was submitted to temporal lobectomy for acute intracranial hypertension developed two years after radiotherapy for a GH-secreting pituitary adenoma. Eight months later, a partial left temporal lobectomy was performed because of further radionecrosis. In both instances the cerebral radionecrosis had the clinical and radiological characteristics of a space-occupying lesion. Bilateral temporal lobectomy was followed by a particular psycho-neurological syndrome with bilateral cortical deafness.

Acromegaly↗
PubMedDate not supplied

Apoptotic and antiproliferative effects of gemcitabine and gemcitabine plus Ara-C on blast cells from patients with blast crisis chronic myeloproliferative disorders.

BACKGROUND: Blast phase of chronic myeloid leukemia (CML) as well as the rare acute transformation of other chronic myeloproliferative disorders constitute forms of leukemia that are particularly refractory, even to aggressive chemotherapy. Many attempts have thus been made to identify new drugs that could be active in these diseases. We wanted to evaluate whether gemcitabine (dFdC), a pyrimidine analogue widely employed in lung cancer chemotherapy, was able to block in vitro proliferation of bcr/abl-positive and bcr/abl-negative blast cells in primary culture. We already showed that gemcitabine is active in inhibiting proliferation and inducing apoptosis of HL60 cells. METHODS: We studied the influence of dFdC on the proliferative potential of blasts by means of tritiated thymidine uptake, colony formation in semisolid medium and cell cycle parameters at flow cytometry. The efficacy of dFdC in inducing apoptosis was evaluated by flow cytometry (A0 peak) and by DNA agarose gel electrophoresis. RESULTS: We demonstrated that dFdC already inhibits tritiated thymidine uptake at doses of 10 microM after 72 hours of culture, and that this effect is dose dependent. The addition of Ara-C 5 microM in the culture medium of dFdC provoked a synergistic inhibitory effect. Consistent results were obtained when cell cycle distribution was studied. In fact, cell incubation in the presence of dFdC resulted in a significant decrease of cells in S phase, although with a certain heterogeneity among cases. The antileukemic activity of dFdC appeared to be specific since it was mediated through apoptosis. We could demonstrate the appearance of the pre-G1 apoptotic peak at cytofluorimetric analysis, and the characteristic DNA fragmentation pattern at agarose electrophoresis in all 10 cases after treatment with different doses of dFdC. Induction of apoptosis was maximal for the highest doses of dFdC (100 mM) and for the combination of dFdC and Ara-C. INTERPRETATION AND CONCLUSIONS: Following incubation with Gemcitabine leukemic blasts from chronic myeloproliferative disorders are induced to accumulate intracytoplasmatic and nuclear Ara-C and undergo apoptosis. These observations suggest that gemcitabine could be considered a candidate drug, capable of being used in polychemotherapy of refractory acute phase chronic myeloproliferative disorders.

Antimetabolites, Antineoplastic↗