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Biomedical subjects

A Berglund

Publications and source records attributed to A Berglund.

83 records · Page 5Linked to original sources
PubMed1978

Adenylate cyclase activity in human liver membranes and its inhibition by adenosine and adenine nucleotides.

The production of adenosine 3',5'-monophosphate (cyclic AMP) in a membrane preparation from human liver homogenate has been studied. Cyclic AMP production was enhanced by glucagon, guanylyl 5'-imidodiphosphate (GMP-PNP), or fluoride, or combinations of these. Adenosine, adenosine monophosphate (AMP) and adenosine diphosphate (ADP) at a concentration of 10(-3) mol/l antagonized the effects of all stimulants. These data suggest that inhibitory effects are exercised at the catalytic moiety of the adenylate cyclase system, or at the transducer function between hormone receptor and catalytic unit. In contrast, adenosine at a concentration of 10(-5) mol/l antagonized glucagon- but not fluoride-stimulated adenylate cyclase activity.

Adenosine↗
PubMed1976

Comparison of IgE values as determined by different solid phase radioimmunoassay methods.

Accurate measurement of low IgE concentrations if technically difficult. In this paper results obtained by a direct sandwich and three inhibition methods of radioimmunoassays are compared. For values above 50 U/ml good correlation was obtained with all methods. Below 50 U/ml, however, the inhibition methods tended to yield falsely high values. For very low concentrations, 1--10 U/ml the best correlation was obtained between the direct sandwich test (PRIST) and the inhibition test using a correction factor to allow for the non-specific effect of serum. The four methods were used to quantify IgE in cord serum samples from healthy individuals. The mean value obtained by PRIST was 0-4 U/ml and by the inhibition test, using a correction factor, 0-6 U/ml respectively. Because of its greater simplicity the direct sandwich test is recommended.

Adolescent↗
PubMedDate not supplied

Prediction of nonlinear optical responses of organic compounds.

The nonlinear optical quantities, second and third harmonics (beta and gamma), were predicted using a quantitative structure-property relationship (QSPR) approach. Molecular orbital ab initio calculations were applied to generate easily accessible variables to be used in the partial least-squares analysis. Simplified equations are presented that could be used to predict the experimental beta and gamma responses, prior to further investigations of potentially interesting molecules for use in optical materials.

Journal Article↗