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Biomedical subjects

A Berger

Publications and source records attributed to A Berger.

At least 631 records · Page 35Linked to original sources
PubMed1972

Retrograde conduction from artificial pacemaker to atria in sick sinus syndrome.

The influence of retrograde conduction of the artificial pacemaker impulse from the right ventricle to the atria exerted upon the occurrence of rapid supraventricular rythms was investigated in patients with sick sinus syndrome. The bouts of tachycardia occurred in cases with fixed V-A retrograde block or coincided with temporary V-A block. The usually operating retrograde conduction from the pacemaker to the atria protects the patients from paroxysms of supraventricular tachycardia by means of the coordinated depolarization of the atria and junctional tissue.

Arrhythmia, Sinus↗
PubMed1970

On the active site of elastase: Partial mapping by means of specific peptide substrates.

RNase-S peptide as well as some related octa- and hexapeptides were found to be highly, reactive substrates of porcine elastase (e.g. Ala(4)-Lys-Phe: K(m) = 4500 M(-1), k(cat) = 32 sec(-1), C = 1.4 x 10(5) M(-1) sec(-1)). Comparison of the various peptides led to the conclusion that the active site of porcine elastase is composed of 6-7 subsites (c.f. [1]). Preliminary mapping shows that subsites S(2), S'(1) and S'(2) have hydrophobic character. Occupation of subsite S(4) by the substrate is important for efficient hydrolysis. Binding at this subsite was found to be stereospecific.

Journal Article↗