Biomedical subjects

A Berg

Publications and source records attributed to A Berg.

313 records · Page 18Linked to original sources

PubMedDate not supplied

Serumlipoprotein cholesterol in sedentary and trained male patients with coronary heart disease.

To demonstrate the influence of exercise training on the lipoprotein cholesterol fractions (high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) cholesterol) in patients with coronary heart disease (CHD), 65 male patients were examined for cardiovascular function and lipid metabolism, before starting or after having participated in a coronary training group for more than one year. There were notable improvements not only in the physical performance data of the trained patients in reference to the tested maximal performance capacity per body weight (MPC/W) as well as the calculated heart volume performance ratio (HVPR) (MPC/W, + 26.0%; HVPR, -18.0%), but also in the lipoprotein cholesterol values and the calculated risk quotient of HDL and total cholesterol (HDL cholesterol, +5.1 mg/dl; LDL cholesterol, -23.3 mg/dl; VLDL cholesterol, -12.5 mg/dl; HDL/total cholesterol, +0.038). The results indicate the positive effect of physical training on lipoprotein cholesterol concentrations, and also in CHD patients in coronary training groups.

Anthropometry↗

PubMedDate not supplied

Hexapropymate self-poisoning causes severe and long-lasting clinical symptoms.

Cases of hexapropymate poisoning requiring intensive care in an urban region of Sweden (420,000 inhabitants) were collected over 2.5 years (1985 to 1987). Only patients with serum hexapropymate concentrations above 5.5 mg/L (30 mumol/L) and with a negative history for intake of tricyclic antidepressants, phenothiazines, barbiturates, antihistaminic drugs and opiates were included. Clinical data about 8 intoxication events in 6 patients were evaluated retrospectively. Initial symptoms included coma, hypotension, hypothermia, and hypoventilation. Maximum coma depth (Glasgow coma score) was 3 to 5 in 5 out of 8 events. On 7 occasions assisted ventilation was required (for 12 hours or more in 5 events). There was no relationship between serum concentrations of hexapropymate and severity of clinical symptoms. All patients survived. Detailed analysis of the drug elimination in one patient showed a terminal elimination half-life of 21 hours, which is longer than previously reported (5 hours). The indications for use of this hypnotic drug may vary between doctors since an 8-fold variation was seen in drug prescription between Swedish counties in 1987. Poisoning with hexapropymate is a serious condition which may require symptomatic treatment in the intensive care unit. The clinical picture is similar to that seen in patients with burbiturate intoxication. There is no role for active forced elimination of the drug. It is questionable whether the clinical value of the drug is outweighted by its toxicity.

Adult↗

PubMedDate not supplied

Effects of electrical stimulation and norepinephrine on cyclic-AMP levels in the cerebral cortex of the aging rat.

One to 24 month old rats were anesthetized with alpha-chloralose, their cerebral cortices exposed surgically and subjected in vivo to stimulation by norepinephrine (1.0mM for 5 minutes) or electrical pulses (100 pulses/s for 10 s). After microwave fixation, cortical samples were analyzed for cyclic-AMP by the Gilman method. In similarly prepared but unstimulated control animals, cyclic-AMP levels were found to be three to four-fold lower in older than in younger rats, a pattern previously reported for unanesthetized rats. Both norepinephrine and electrical pulses led to cyclic AMP increases. With increasing age the cyclic-AMP levels attained under both stimulus conditions declined, with the levels achieved in the two cases becoming increasingly divergent.

Aging↗

PubMedDate not supplied

The parallel process in clinical supervision with a schizophrenic client.

The authors analyze a male nurse's account of how he experienced his interaction with a female schizophrenic client during sessions of systematic clinical supervision. Notes taken during 15 sessions were analyzed by means of open coding. The analysis revealed the importance of being aware of the parallel process that occurs among the client, the primary nurse, and the unit staff.

Adult↗

PubMedDate not supplied

Semiautomated monolayer preparation of bronchial secretions using AutoCyte PREP.

OBJECTIVE: Development of a method for semiautomated preparation of purified, representative and conventionally stained monolayer smears from bronchial secretions suitable for subjective and/or automated cytodiagnosis. STUDY DESIGN: Bronchial secretions from 50 patients with and 48 without carcinoma cells of different types were collected in Saccomanno's fixative. After routine pick-and-smear processing, residual material was subjected to a mucolytic agent (ammonium thioglycolate). Separation of cells was performed by differential centrifugation through aqueous sucrose. The pellet was automatically processed by the AutoCyte PREP system. RESULTS: Slides revealed well-preserved, slightly shrunken, homogeneously distributed cells devoid of mucus, cellular debris and bacteria in monolayer arrangement nearly without overlap. Granulocytes were eliminated to a large extent. Comparison with pick-and-smear specimens showed more tumor cells per square centimeter of slide surface in 100% of AutoCyte PREP slides. The number of tumor cells per AutoCyte PREP slide was higher in 46% and lower in 54%. Selecting slides at random and requiring at least 10 abnormal cells to establish a tumor diagnosis were achieved in 82.7% if only one, in 88.0% if two and 94.0% if seven or eight AutoCyte PREP slides were investigated. CONCLUSION: The semiautomated method yielded conventionally stained, purified monolayer smears from bronchial secretions with cellular morphology suitable for evaluation by cytologists and screening machines. Representativity of AutoCyte PREP monolayers was superior to that of pick-and-smear slides.

Adenocarcinoma↗

PubMedDate not supplied

Novel spiciferone derivatives from the fungus Drechslera hawaiiensis isolated from the marine sponge Callyspongia aerizusa.

From the marine sponge Callyspongia aerizusa collected from the Sea of Bali, Indonesia, fungal isolates of Drechslera hawaiiensis were obtained. Culture filtrates of the fungus yielded four spiciferone derivatives which include spiciferone A (1) and B (2), and two other novel derivatives including spiciferol A (3) which is an alcohol congener of spiciferone A (1) and compound 4 which is an monocyclic spiciferone congener featuring a butoxyl side chain. The structures of the novel compounds were established on the basis of NMR spectroscopic (1H, 13C, COSY) and mass spectrometric (EIMS) data.

Animals↗

PubMedDate not supplied

Effects of antirheumatic treatment on gastric secretory function and salivary flow in patients with rheumatoid arthritis.

Many patients with rheumatoid arthritis have impaired gastric acid secretion and dysfunction of the lacrimal and salivary glands, conditions which have been proposed to be due to glandular atrophy. The hypothesis that the rheumatoid inflammation by itself has a depressive effect on these secretory functions was tested on 20 patients with active rheumatoid arthritis who underwent 16 weeks of sulphasalazine therapy. The patients responded well to the treatment, with reduction of joint indices and acute phase reactants. The resting and stimulated whole salivary secretion rate increased in 9/10 and 8/10 patients, respectively. The maximal gastric acid output increased in those patients who had a moderate reduction in acid output prior to treatment. When estimated by s-pepsinogen I, the gastric secretory capacity increased in all patients but one. In a group of auranofin treated patients, s-pepsinogen I rose only in those who responded to treatment with reduced disease activity. These results support the idea that the impaired secretory functions are at least partially reversible and probably also partly inflammatory mediated.

Adult↗