Search PubMed⌕ Search

Biomedical subjects

A Benderly

Publications and source records attributed to A Benderly.

At least 73 records · Page 4Linked to original sources
PubMed1982

Analysis of a monofluorinated analogue of amphetamine in brain tissue using gas chromatography with electron-capture detection.

1. Difficulties encountered in the analysis of the monofluorinated amphetamine, 2-amino-3-fluoro-1-phenylpropane (AFP), are discussed. 2. A novel assay procedure and its application to the analysis of AFP in the rat brain are described. The procedure involves pentafluorobenzoylation of AFP under aqueous conditions and quantitation by a gas chromatography equipped with a capillary column and an electron-capture detector.

Amphetamines↗
PubMed1982

Interaction of beta-carbolines with the benzodiazepine receptor. Structure-activity relationships of amide derivatives of beta-carboline and tetrahydro-beta-carboline.

1. The inhibition of specific 3H-flunitrazepam binding to rat cortical membrane preparations (benzodiazepine receptors) by a series of amide derivatives of beta-carboline and tetrahydro-beta-carboline related to the ethyl ester of beta-carboline 3-carboxylate (beta-CCE) was measured. 2. beta-Carboline amides which are unsaturated in the C ring of the beta-carboline nucleus were the most potent inhibitors of benzodiazepine receptor binding. 3. Increasing the length of the hydrocarbon moiety in the aliphatic amide side chain beyond two carbon atoms decreased potency.

Animals↗
PubMed1982

Clinical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.

Studies in 18 Jewish families from Morocco, Tunis, Turkey and Iran revealed 26 patients with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. The clinical expression of androgen excess varied widely in affected females, and range from solely enlarged clitoris in the mildest forms to severely hypertrophied clitoris with penile urethra and fused labial-scrotal folds in the most extreme forms of masculinization. Intermediate degrees of severity were manifested by ambiguous genitalia. There was no correlation between the degree of virilization and the signs of mineralocorticoid excess. Severe volume-induced hypertension leading to vascular accidents and death were also observed in severe as well as in mildly virilized patients, while completely masculinized females were sometime normotensive. Overt hypokalemia was present in 6 patients but was not a constant feature of hypertensives. However, all affected individuals, except for 2 infants, had very low levels of plasma renin activity suggesting that a state of volume expansion was indeed present in the majority of cases, even though changes in blood pressure did not always occur. The clinical expression of this disorder is characterized by a wide range of variability in the signs of both androgen and mineralocorticoid excess, which do not necessarily correlate with the quantity of hormones secreted.

Adolescent↗
PubMed1981

Interactions of beta-carbolines with the benzodiazepine receptor: structure-activity relationships.

The effects of a number of beta-carboline derivatives on [3H]flunitrazepam binding to the benzodiazepine binding site were investigated. The potency of beta-carbolines at the benzodiazepine binding site appeared to be determined largely by the aromaticity of the molecule. Norharmane-3-carboxylic acid ethyl ester was considerably more potent (IC50 10 nM) than its tetrahydro-beta-carboline analogue (IC50 6 microM). There is essentially no difference in potency between the (+)- and (--)-forms of the tetrahydro-beta-carboline-3-carboxylate analogues.

Animals↗
PubMed1981

Mitral valve replacement in active rheumatic heart disease in a five years old child.

A case of a five-year-old patient with severe rheumatic mitral regurgitation is reported. Intensive anticongestive and corticosteroid therapy were ineffective. Despite the diagnosis of chronic carditis she underwent successful mitral valve replacement with significant improvement of her cardiac status. Valve replacement is indicated in a certain group of patients with rheumatic heart disease which have a poor prognosis on medical therapy alone.

Child, Preschool↗
PubMed1981

Splenic abscess in infancy--diagnosis by ultrasonography.

Splenic abscess is a rare entity in children, and definite diagnosis is seldom made before operation. A case of splenic abscess in a high-risk infant is reported. An accurate diagnosis has been made preoperatively by ultrasonography. Characteristic sonographic findings are described.

Heart Defects, Congenital↗
PubMed1980

Determination of 5-hydroxytryptamine in rat brain regions by gas-liquid chromatography with electron-capture detection.

An assay method for measurement of 5-hydroxytryptamine in rat brain areas is described. The procedure involves extraction with a liquid ion exchanger followed by acetylation and reaction with pentafluoropropionic anhydride. The resultant beta-carboline is separated and quantitated using gas-liquid chromatography with electron-capture detection. The procedure also works well with 5-methoxytryptamine standards, and the tissue samples were checked simultaneously for the presence of this amine. The results indicate that concentrations of 5-methoxytryptamine in all areas studied (brain stem, hypothalamus, frontal cortex, and striatum) are less than 10 ng/g.

5-Methoxytryptamine↗
PubMed1979

Side-chain monofluorinated analogs of amphetamine and p-chloroamphetamine. Effects on release of dopamine and 5-hydroxytryptamine from rat striatum.

Monofluorinated analogs of (+/-)-amphetamine and (+/-)-p-chloroamphetamine, in which the methyl group was replaced with a monofluoromethyl group, have pKa values approximately 1.65 units lower than those of their amphetamine counter-parts but retain some ability to stimulate release of dopamine and 5-hydroxytryptamine, respectively, from rat corpus striatum.

Amphetamines↗