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Biomedical subjects

A Ben Osman

Publications and source records attributed to A Ben Osman.

33 records · Page 2Linked to original sources
PubMed1996

[Comparative epidemiology of pemphigus in Tunisia and France. Incidence of foliaceus pemphigus in young Tunisian women].

INTRODUCTION: Recent studies have suggested that pemphigus foliaceus is quite frequent in young Tunisian women. In order to confirm this hypothesis, we compared the incidence of pemphigus in general in Tunisia with that in the Ile-de-France region. METHOD: All new cases of pemphigus diagnosed during a 6-year period were reviewed in our dermatology and pathology laboratories. These cases were classed as pemphigus foliaceus or pemphigus vulgaris on the basis of histology reports. RESULTS: In France, the incidence was 1-7 new cases per million per year (95 p. 100 confidence interval 1.4-2.1). Pemphigus vulgaris was diagnosed in 73 p. 100 of the cases with an incidence increasing with age. Sex ratio (F/M) was 1.2. The incidence observed in Tunisia was significantly higher than that observed in France with 6.7 new cases per million per year (95 p. 100 confidence interval 5.8-7.7). Pemphigus foliaceus was more frequent (61 p. 100), the sex ratio (F/M) was 4.1. Incidence was higher in young women, with 20 new cases of pemphigus foliaceus per million per year among women from 25 to 34 years of age. These levels were higher in rural desert areas. No familial cases were observed and only one case occurred in a child. DISCUSSION: These findings confirm the specific epidemiology of pemphigus in Tunisia, which appears to be similar and also different from that in Brazilian pemphigus. As in Brazil, there was a predominance of pemphigus foliaceus in young adults living in rural areas in poor socioeconomic conditions. However in Tunisia the disease predominates significantly in women and there are no familial and rare juvenile cases.

Adult↗
PubMed1995

Comparative epidemiology of pemphigus in Tunisia and France: unusual incidence of pemphigus foliaceus in young Tunisian women.

Recent studies have suggested that in Tunisia, pemphigus foliaceus is more frequent in young women than expected. To confirm these findings, we compared the incidence rates of pemphigus in Tunisia as a whole and in a large area of France. New cases of pemphigus were detected retrospectively from dermatology departments and pathology laboratories over a 6-year period and classified as pemphigus vulgaris or foliaceus according to the pathology. In France, the incidence rate was 1.7 cases per million per year (95% confidence interval 1.4 to 2.1). Pemphigus vulgaris accounted for 73% of all cases, incidence increased with age, and the female-to-male sex ratio was 1.2. The incidence rate was significantly higher in Tunisia than in France: 6.7 cases per million per year (95% confidence interval 5.8 to 7.7); pemphigus foliaceus was more frequent (61%), the female-to-male sex ratio was 4.1, and the incidence rate was higher in young women. The incidence rate was 15.5 cases per million per year for pemphigus foliaceus among women aged 25 to 34 years and was even higher in some rural areas. No case was observed among household members or in neonates, and only one case occurred in childhood. Thus, we confirmed that the epidemiology of pemphigus in Tunisia is unusual. High rates of pemphigus foliaceus among young people living in rural areas are reminiscent of Brazilian pemphigus. However, the absence of cases among genetically related household members and during childhood, and the large predominance of women, contrast with Brazilian pemphigus.

Adult↗
PubMed1995

[Spontaneous course of lesions of Leishmania major cutaneous leishmaniasis in Tunisia].

INTRODUCTION: The evolution of zoonotic cutaneous leishmaniasis (ZCL) caused by L. major, was usually described with crosssectional studies of patients under anti-leishmanial drugs. This work aimed to describe the clinical and parasitological status by a follow-up study of patients with ZCL and treated with a placebo. MATERIAL AND METHODS: In 1992, 58 patients with unique lesion of ZCL confirmed parasitologically and treated with vaseline twice a day for 15 days were followed in days 0, 15, 45 and 105. During every visit we have performed a clinical description of the lesion, a direct smear and a culture on NNN medium. RESULTS: 81 p. 100 of the lesions were ulcerated in day 0. A rapid clinical healing was noticed in 6.9 p. 100 of patients and the lesion remained active in 25.9 p. 100 of cases until day 105. Direct smears became negative among 56.4 p. 71 p. 100 and 92.3 p. 100 in days 15, 45 and 105 respectively. DISCUSSION: The ulcer was the most frequent sign during the diagnosis. The rapid conversion of positive parasitological tests suggest that the diagnosis of ZCL in endemic zones should be based mainly on clinical criteria.

Adolescent↗
PubMed1994

[Keratoacanthoma centrifugum marginatum].

INTRODUCTION: Keratoacanthoma centrifugum marginatum (KCM) is a rare keratoacanthoma. Treatment relies essentially on exeresis which is however difficult due to the widespread nature of the lesions. CASE REPORT: A patient with a 1 year history of KCM associated with psoriasis vulgaris was successfully treated with etretinate (1 mg/kg/day) for 5 months. This medical therapy made it possible to avoid the classical surgery and to blanch the associated psoriasis. COMMENTS: Several authors have shown the favourable effect of etretinate on multiple or large single-site keratoacanthomas. To our knowledge, this is the first case reported of successful treatment with etretinate in a case of keratoacanthoma associated with psoriasis. We suggest that this drug could be an effective alternative to mutilating surgery for this specific variety of keratoacanthoma.

Aged↗
PubMed1994

[Type 1 neurofibromatosis in Tunisia: 66 cases].

A multidisciplinary transversal descriptive study was conducted from June to October 1992 to determine the clinical manifestations and laboratory findings observed in 66 patients with type 1 neurofibromatosis. Diagnostic criteria were those of the National Institute of Health as recommended for subjects over 20 years of age. All patients over the age of 25 had café au lait spots, neurofibromas, lentigines and nodules. Occurrence of lesions of the central nervous system was significantly earlier than peripheral nervous manifestations. The optic glioma was the most frequent lesion of the central nervous system. Complications were observed during the first twenty years of the disease. Based on these findings, we propose a clinical and laboratory work-up designed as a function of age.

Adolescent↗
PubMed1993

[Dermatitis herpetiformis and chronic diarrhea: a case].

We report on a case of dermatitis herpetiformis in an eight-year-old boy presenting diarrhoea, short stature and characteristic skin rash. Jejunal biopsy showed a partial villous atrophy. The diagnosis was confirmed by immunofluorescence which showed granular IgA deposits in the papillary dermis. On a gluten-free diet associated with dapsone, the child gained weight and height, with partial resolution of the rash.

Child↗
PubMed1988

[Clinico-epidemiologic forms of cutaneous leishmaniasis in Tunisia].

From an analysis of 1,546 cases of cutaneous leishmaniasis collected throughout Tunisia three clinico-epidemiological forms could be determined. These forms are due to three different species of Leishmania and are observed in different geographical areas. Sporadic cutaneous leishmaniasis (SCL), 63 cases. This form is found in Northern Tunisia, in known foci of Kala-azar. 96% of the patients have a single, small, ulcerated and crusty lesion on the face surrounded by an important zone of infiltration. Amastigotes are less than 4 microns in diameter, and it is very difficult to maintain the parasites in cultures. This form is probably due to Leishmania infantum, as has been demonstrated in Algeria in a similar form evolving in the same biotope as the Tunisian form. The vector and reservoirs of SCL are unknown. Zoonotic cutaneous leishmaniasis (ZCL), 1,412 cases. The disease is epidemic in Central and Southern Tunisia. The lesions are multiple; they affect the limbs more frequently than the face and heal in less than 8 months. They are polymorphous, usually large and superinfected. There is a seasonal occurrence of the outbreaks (summer and autumn). Amastigotes are large (4 to 6.5 microns in diameter) and the parasites easily grow in cultures. This form is caused by Leishmania major, and its vector is Phlebotomus papatasi. Three species of rodents harbour the parasite. Anthroponotic cutaneous leishmaniasis (ACL), 71 cases. This form is endemic in South-Eastern Tunisia. 70% of the patients present with single lesions, one half of which affect the face. Dry and proliferating lesions are the most frequent.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗