[Apropos of geometrical phagedenic ulcers observed in Senegal].
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Biomedical subjects
Publications and source records attributed to A Bellossi.
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In previous studies it has been shown that exposure of mice to a 12-Hz 6 mT unipolar square pulsed magnetic field (PMF) suppressed the excess of weight due to application of 1st cold-pressure sunflower oil. This time we considered the effect of oil and/or PMF on the growing curves lifespans of mice. The exposure took place for 30 min 5 days a week, from the 7th week of life to death. The results are 1) a broken slope in the growing curves from the 125th day of aging: the exposed mice were lighter than the controls, keeping the differences between the growing curves needed a repeated exposure all life long; 2) a significant increase in the lifespan of the controls which received oil versus the controls which received water; 3) an increase in the lifespan of the exposed mice versus the non-exposed control batches. On one hand it has been reported that essential polyunsaturated fatty acids found in first cold-pressure sunflower oil played a prominent role in membrane structures and in immune equilibrium. On the other hand, it was shown that oscillating electric fields could activate Na+K+-ATPase.
AKR mice were exposed to a 6 mT, 12 Hz or 460 Hz pulsed magnetic field for 30 minutes twice a week. The exposure took place in utero and/or during the life span for five consecutive generations. For the exposure the grown-up mice were put into a container which caused a restraint stress. That stress brought about lighter newborn mice and also a higher number of newborn mice which were to die. The exposure lessened the loss of weight due to the stress. It had no noticeable effect on the average numbers of newborn mice per litter, of dead newborn mice and on the sex-ratio.
In a previous experiment, the exposure of tumoral C3H/Bi female mice to a 9 mT, 460 Hz pulsed magnetic field led to an increase in the length of survival in the late period of the disease; this might be due to a hampered metastatic process. In the present study 27 controls and 52 exposed mice were treated with the same protocol (a 10-minute exposure, 3 non-consecutive days a week, from 2-3 weeks after the tumors appeared until death) but with a 12 Hz PMF. In this experiment the 12 Hz PMF appeared to increase length of survival times in the early period of the disease.
The hypothesis that magnetic fields act only on deficient functions has been tested through the weight of the thymus in mice. The involution of the thymus in mice is known to begin early in life. It is marked by a decrease in weight. Female Swiss mice of different ages were exposed to a pulsed magnetic field 0.6 or 6 mT in intensity, 12 or 460 Hz in frequency. It was shown that the weight of the thymus in 8-week-old mice was not modified by the exposure, while the weight of the thymus in 15-week-old mice was increased. The maximum increase, about 16% relative to the controls, was obtained 24 hours after a 30 minutes' exposure. Hydrocortisone or cyclophosphamide prevented the effect. The increase in weight has been considered to be due to an increase of the number of the cells in the thymus.
In a previous experiment an increase in the survival time of leukaemia-prone AKR mice was observed by exposure to a 600 mT or 800 mT static magnetic field when the mice were at least 200 days old. In this experiment 200-day-old-mice were exposed to a 6 mT pulsed magnetic field (PMF) for 30 minutes a day, twice a week until death. The frequency of the field was 12 Hz or 460 Hz. The exposed mice died from leukaemia but had an increased survival time; the average increase was 14.25% compared to the controls. Both the frequencies gave similar results.
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From the study of 80 patients, the authors show the interest of abdominal thermography to explore a portal hypertension. Linear stripes, stellar pictures, periumbilical hot spot are specific pictures. These thermographic modifications come before cutaneous venous signs in half of the population. Their interest for prognosis remains to be specified.
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This work was undertaken to check the effects of 460 Hz pulsed magnetic fields (PMF) on the growth curves of mice, and to observe any possible long term effect. Effects on the growth curves have already been shown in young female AKR mice. Eight-week-old Swiss female mice underwent, until death, a twice weekly a one-hour-exposure to a 460 Hz 6 mT PMF. They initially showed slower than that of the controls, but it later became faster, 460 Hz 9 mT PMF always kept the growth curves of the exposed mice under those of the controls. However, no difference with controls was noticed when the mice were exposed after the thirtieth week. Moreover, there was no difference in the survival or in pathological aspects between the exposed mice and controls.
In a previous work a decrease in cholesterol and triglyceride plasma levels was observed in rats 24 hours after their exposure to a 12 Hz 6 mT pulsed magnetic field (PMF). This time, a study of intensity effects of a 12 Hz PMF for a sixty-minute exposure and of length of exposure for a 12 Hz 6 mT PMF took place. Non-linear effect-dose relationships were observed for the PMF intensity as well as for the length of exposure used. The highest decreases in cholesterol and triglyceride levels were obtained after to a sixty-minute exposure with 1.5 mT and 12 mT.