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Biomedical subjects

A Bellossi

Publications and source records attributed to A Bellossi.

At least 19 recordsLinked to original sources
PubMed1998

Effect of pulsed magnetic fields on triglyceride and cholesterol levels in plasma of rats.

BACKGROUND: Liver is a crucial organ in metabolism. For instance liver is the main source of circulating lipoproteins. METHODS: In this paper cholesterol and triglyceride plasma levels were measured in male rats previously exposed to pulsed magnetic fields (PMF) used in therapy. Rats underwent a one-hour exposure to a 6 mT 12 Hz PMF. RESULTS: Twenty-four hours after the end of the exposure to the PMF the rats' livers were heavier, cholesterol and triglyceride plasma levels decreased. All these variations were significantly different according to a variance ratio test as was a rebound in triglyceride level 48 hours after the end of the exposure. Normal values were observed 48 and 96 hours after the end of exposure respectively for cholesterol and triglycerides. CONCLUSIONS: These alterations may be due to a reversible accumulation of either triglycerides or of their precursors in liver following acute exposure to a 12 Hz PMF.

Animals↗
PubMed1996

The effect of a pulsed magnetic field and that of methyl-silane triol on galactosamine induced hepatitis among rats.

Liver cell necrosis was induced in rats by a galactosamine injection. Cell death was due to an increase of Ca++ intracellular levels and was also under the control of genes. Rats were then either exposed or not to a 6 mT 100 HZ pulsed magnetic field (PMF) and they either received or not methylsilane-triol injections. Animals were sacrificed twenty-seven hours after a galactosamine injection. On the one hand it appeared from transaminase levels that the PMF increased the number of animals which were sensitized to galactosamine but decreased transaminase levels. On the other hand PMF decreased the protective effect of MST against galactosamine. We may suggest that PMF should be considered as an additional cellular signal received through genes which would determine the evolution towards or against apoptosis according to the age of the cell itself but also the Ca++ intracellular level.

Animals↗
PubMed1993

Exposure of C3H/Bi female mice with mammary carcinoma to pulsed magnetic fields.

Pulsed magnetic fields (PMF) have already proved to have a certain influence not only on leucocytes in vitro but also on thymocytes in vivo. C3H/Bi tumoral female mice were either exposed to 12 Hz or 460 Hz, and to 6, 9 or 20 mT PMF just two weeks after the tumors had appeared and this until the moment they died. Actually, all the survival times as well as the average weights of spleens lungs, and tumors were then taken into account at the very death of the mice. In a general way there happened to be no difference in spite of the different frequencies used and the rates of lungs with metastases were not at all influenced by the exposure itself. However a 3-hour-exposure once a week could increase the mean survival times whereas a 15-minute-exposure to a 6 mT PMF twice a week gave lighter spleens than those of the controls and an exposure either to 9 mT or to 20 mT gave heavier tumors in general.

Animals↗
PubMed1992

Effect of a 12 Hz and of a 460 Hz pulsed magnetic field on the weight of AKR mice.

AKR mice were exposed to a 6 mT, 12 Hz or 460 Hz pulsed magnetic field (PMF) 30 minutes twice a week. The exposure took place in utero and/or during the life span for four consecutive generations. The adult mice exposed to the 460 Hz PMF only after the birth time were lighter than the controls; for the two frequencies the decrease in weight with the ageing was less pronounced than in the controls. When the exposure took place in utero the exposed new-born mice were heavier than the controls. The difference in weight progressively disappeared when the mice were exposed to the 12 Hz PMF, persisted when the mice were exposed to the 460 Hz PMF.

Animals↗
PubMed1991

Effect of pulsed magnetic fields on leukemia-prone AKR mice. No-effect on mortality through five generations.

Leukemia-prone AKR mice were exposed twice a week to a 6 mT, 12 Hz or 460 Hz pulsed magnetic field for 30 min. If we take into account the five consecutive generations of mice, the above exposure actually took place in utero and, or during their life span. There was no difference in the incidence of leukemia or in the actuarial survival curves or in the average spleen or thymus weights.

Actuarial Analysis↗
PubMed1991

Effect of pulsed magnetic fields on healthy mice, a study through cellular electrophoresis of thymic cells.

An exposure of adult mice to a pulsed magnetic field (PMF) increases thymus weight. In this work, thymic lymphocytes were studied by cellular electrophoresis because the proliferation and maturation of these cells is linked to an increase in their electrophoretic mobility (EM). Fifteen-week-old female Swiss mice were exposed for 30 min to a 6 mT PMF, 12 or 460 Hz in frequency, according to different modalities. The EM of the thymic cells, suspended in saline were measured from 0 to 96 h after the end of the exposure. For some of the mice the whole body, for others the head only or the body without the head was exposed; the animals were awaken or narcotized, prepared or not with 6-hydroxydopamine. The modifications of the EM are in favour of an action of the PMF on the thymus through the central nervous system.

Animals↗
PubMed1988

Effect of a pulsed magnetic field on tumoral C3H/Bi female mice.

Female C3H/Bi mice develop spontaneous viral mammary carcinoma which can metastasize to the lungs. Two hundred and forty tumoral mice were either exposed to a toroïdal pulsed magnetic field, 12 Hz, 100 Hz or 460 Hz in frequency or used as controls. The exposure was mainly done 10 min. a day, 3 days a week, or 30 minutes once a week from about 2 to 3 weeks after the appearance of the tumors until death. In comparison with the controls, the exposed mice showed lighter spleens and lungs; this last observation could mean fewer pulmonary metastases. The weight of the tumors has been found lighter for 460 Hz MF, not changed for 100 Hz MF, heavier for 12 Hz MF, but lifespans were not altered by the exposure.

Animals↗
PubMed1987

Effects of constant magnetic fields on the B-cells and insulin target cells in the rat.

Young male rats were exposed to constant uniform magnetic fields of 400 and 800 millitesia (mT). No changes were observed in the body and in the pancreas weight, in the pancreatic insulin content and in the in vitro insulin release of Langerhans islets, in glucose and insulin plasma levels. The magnetic fields abolished the insulin effect on glucose uptake of diaphragms, but not on 1-14C-glucose oxidation. In adipocytes 400 mT increased insulin-stimulated 1-14C-glucose oxidation, when expressed as percentage of mean basal oxidation, and 800 mT diminished it.

Adipose Tissue↗
PubMed1986

Effect of static magnetic fields on survival of leukaemia-prone AKR mice.

The influence of a life-long exposure to static magnetic fields (SMF) on the lifespan of female AKR mice which develop spontaneous lymphoblastic leukaemia was investigated. Exposure all day long to a circular SMF, 4.6 mT maximal intensity or 2 h a day, 5 consecutive days a week to a uniform SMF of 400 mT did not modify the lifespan of mice. Exposure 2 h a day, 5 consecutive days a week to a uniform SMF of 600 or 800 mT modified the lifespan: about 50% of the population had a longer survival than the controls. Mice exposed 30 min a day 5 consecutive days a week to a non-uniform SMF presented the same trend.

Aging↗
PubMed1984

Effects of constant magnetic fields on rats and mice: a study of weight.

Variations in the growth of animals from exposure to a magnetic field have been reported by several authors. In this study, young rats and mice were exposed daily to constant uniform magnetic fields. The strength of the field was 400, 600 or 800 mT. Rats were exposed for 4 weeks and mice for 250 d or more. Some mice were exposed in a permanent way to a non-uniform magnetic field of 4.6 mT. No significant effect on the growth was observed.

Animals↗
PubMed1981

The effect of a constant and uniform magnetic field on mouse brain: a study by magnetic nuclear resonance.

Modifications in brain functions after exposure to a constant magnetic field have been noted in animals. For some authors, the main factor is the action of magnetic fields on tissular water. The relaxation times obtained by proton nuclear magnetic resonance should therefore be modified. Mice were placed in a 0.6 T constant magnetic field for 2 h. Their brain relaxation times (spin-lattice T1 and spin-spin T2), were measured 1-5 d after exposure and do not seem compatible with an initial and important modification of the water structure.

Aging↗