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Biomedical subjects

A Batista

Publications and source records attributed to A Batista.

27 records · Page 2Linked to original sources
PubMedDate not supplied

[Autoimmune cholangiopathy].

We report two patients with mixed characteristics of primary biliary cirrhosis and autoimmune hepatitis. They are two female patients in their fifties (54 and 58 years-old) one of them with autoimmune phenomenon, rheumatoid arthritis and Sjögren syndrome. Both of them showed laboratory values of cholestasis and the liver biopsy revealed liver cirrhosis with significant lesions of the bile ducts. They were treated with prednisolone with a rapid improvement and normalisation of their blood tests. They belong to a group called as overlap syndrome or autoimmune cholangitis with mixed characteristics, clinical, biochemical, immunological, and histopathologic overlapping between primary biliary cirrhosis and autoimmune hepatitis type I.

Autoimmune Diseases↗
PubMedDate not supplied

[Crohn disease with unusual cutaneous expression].

Perianal fistula is a frequent complication of Crohn's disease. The diagnosis of the later may be difficult if cutaneous disease is dominant, and sometimes an important clinical challenge. The authors report a case of a 34 year old male complaining of painful perianal nodules for the three last years. Cutaneous histopathological examination was inespecific and colonoscopy normal. Pelvic CT scan and fistulography showed an intercommunicated fistular system invading both isquiorectal fossae, without intestinal communication. Repetition of colonoscopy showed normal mucosa, but in two of the biopsy samples noncaseous granulomas were found at the submucosa. The authors explain their main difficulties to reach the diagnosis of Crohn's disease and discuss the investigation and the evolution of the patient.

Adult↗
PubMedDate not supplied

[Idiopathic proctocolitis. Follow-up (1-13 years) of 71 patients].

Follow-up was possible in 71 of 74 patients with idiopathic proctocolitis diagnosed and/or assisted at the Department of Gastroenterology of the Centro Policínico de Almada, between 1973 and 1985. The aim of the present study was to verify the natural history of the disease and if there were statistically significant differences depending on the extension of the disease (proctitis versus colitis). Complications were present in 22 patients (31%): peri-anal (10%), local or intestinal (24%) and extra-intestinal (28%). Fifteen patients (21% of the cases) had hospital admission at least once, and 2 of them (3%) were submitted to surgery. No cases of cancer of the colon and rectum were detected and mortality was nil. Forty-one patients (58%) were assymptomatic at the last observation (45% with colitis and 75% with proctitis). There were statistically significant differences between the group of patients with ulcerative colitis and that of proctitis concerning the total number of complications (p less than 0.001), local complications (p less than 0.01), extra-intestinal complications (p less than 0.05), need for hospital admission (p less than 0.001) and absence of symptoms at the time of last observation (p less than 0.05), thus confirming a better prognosis of the disease when only the rectum is involved.

Adult↗
PubMedDate not supplied

Chronic headaches and sleep disorders.

BACKGROUND: Headaches and sleep problems are common complaints in the daily practice of the general practitioner. Since the relationship between headaches and sleep complaints is complex, clear models of interaction are needed for adequate diagnosis and treatment. METHODS: All subjects, successively seen in a headache clinic during a defined period, were subdivided based on the time of onset of cephalalgia. Subjects who reported onset of headache on a long-term basis, during the nocturnal or early morning (before final awakening) period, were systematically studied by a headache clinic and a sleep disorders center. This subgroup represented 17% of the total headache group. RESULTS: Although the results of the headache clinic study did not differentiate this subgroup from the other patients, the sleep disorders center's interviews and questionnaires demonstrated a significant impact of the sleep disorders on headache and daytime function. Nocturnal monitoring during sleep identified specific sleep disorders in 55% of the subjects with onset of headache during the nocturnal sleep period. Follow-up after treatment of the sleep disorder showed that all subjects with an identifiable sleep disorder reported either an improvement or absence of their headache. The subjects identified with periodic limb movement syndrome were mostly those who reported only an improvement in their sleep and still needed treatment for their headaches. The question of the interaction and association of sleep-related headache and periodic limb movement syndrome is unresolved. CONCLUSION: Headaches occurring during the night or early morning are often related to a sleep disturbance.

Adult↗
PubMedDate not supplied

Diphenylhydantoin-induced hepatitis: a case report.

This case report is of a 25-year old man with severe diphenylhydantoin-induced hepatitis, fever, rash and generalized lymphadenopathy. Hepatic histology and lymphocyte transformation tests strongly supported the diagnosis. He made an uneventful recovery with supportive therapy.

Adult↗