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Biomedical subjects

A Basso

Publications and source records attributed to A Basso.

At least 127 records · Page 7Linked to original sources
PubMed1976

Hypoglycaemia induced by adrenal gland neoplasia (Anderson's syndrome) : report of a case.

A patient with hypoglycaemia associated with an adrenal neoplasia (Anderson's syndrome) is reported. Endocrinological investigation showed increased secretion of cortisol and catecholamines as well as an increased urinary steroid excretion along with profound inhibition of both basal and stimulated insulin secretion. During IVGTT, Conard's coefficient was reduced. The hyperglycemic response to glucagon injection was blunted, suggesting that liver glycogen stores were decreased or unavailable.

Adrenal Gland Neoplasms↗
PubMed1975

Afterdischarges elicited by electrical thalamic stimulation in the hemicerebellectomized baboon.

Electrical stimulation of the ventrolateral (VL) nucleus of the thalamus was performed on hemicerebellectomized baboons. Stimulation was delivered in volleys of 40 to 60 Hz lasting 5 to 25 sec, and at intensities ranging from 1 to 6 mA (width of shock 0.5 to 5 msec). Similar parameters of stimulation produced asymmetrical motor and electrocortical responses. When the normal VL nucleus was stimulated, these responses were tonic or tonic-clonic. When the VL nucleus deprived of its cerebellar afferents was stimulated, the tonic-clonic responses were followed by afterdischarges appearing in the EEG which persisted after cessation of stimulation. The role of the cerebellum in the lowering of the excitability threshold of some structures, particularly the VL nucleus, is discussed, as are the systems likely to play a role in producing various clinical responses.

Animals↗
PubMed1975

[Controlled study of language re-education in aphasia: comparison between treated and untreated aphasics].

This study was undertaken in order to ascertain the specific effect of language rehabilitation on the oral expression of aphasic patients. The outcome of language disorders has been investigated in 185 aphasics (91 reeducated and 94 not reeducated) submitted to control examination at least 6 months following the first examination. Four of the main variables involved in the recovery process were studied: a) dependent variable, i. e., improvement, and the effects thereupon of 3 independent variables, i. e., a) the time interval between onset of aphasia and first examination, b) clinical type of aphasia on first examination and c) presence or absence of rehabilitation between first and second examination. Age, educational level, etiology and the time interval between first and second examination were controlled in all comparisons. The statistical analysis has established that language rehabilitation has a positive effect on the improvement of oral expression, while the duration of aphasia at the time of the first examination has an equally significant, but negative effect on improvement.

Adult↗
PubMedDate not supplied

Increased immunological efficiency in young mice by short-term treatment with L-thyroxine.

Treatment of young mice with L-thyroxine increases their capacity to form hemolytic plaques after sheep erythrocyte immunization. Such an increment is independent from the quantity of antigenic challenge, from sex and strains variations and from the temporal relationship between timing of hormonal treatment and antigenic challenge. The increment seems to depend on an increased number of both T and B reactive cells, rather than on an augmented proliferation rate of antigen triggered cells. The thyroxine induced increase of T reactive cells requires the presence of a functional thymus. These data suggest that the maximal immune response obtained under physiological conditions does not correspond to the maximal potentiality which can be expressed through appropriate manipulation of the internal microenvironment and further confirm the relevance that thyroxine may have as an immunostimulant agent.

Adjuvants, Immunologic↗
PubMedDate not supplied

Functional interrelationships in aging processes: alterations and reversibility.

The problem of assessing the relevance of the reversibility of age-related functional alterations for aging studies has been presented. Transduction mechanisms of adrenergic stimulation have been chosen as the target of age-related changes and thymus as the effector of some corrective interventions performed at advanced age. Both alterations of adrenoceptor characteristics and their reversibility have been reviewed. beta-adrenoceptors have been studied in organs bearing only one subtype of receptors or both, revealing an age-related decrease in density only in the beta1-subtype. It has been shown that a similar age-related decrease is present in alpha1-adrenoceptor density. Such alterations are corrected by grafting a neonatal thymus into old mice. On the contrary, thymus fails to correct the alteration of T4-induced upregulation of beta-adrenoceptors indicating some limits to its corrective effect when the net of functional interrelationships becomes relatively complex. Both failures and successes of thymic grafts and thymic extracts in reversing age-related changes are discussed taking into account the effects induced on the life span of the animals. Different unsolved problems stemming from the previous considerations are also presented. Among them the controversial question about linearity and non-linearity of biological parameters presumed to be good indices of aging is discussed, with the aid of a simple model as a schematic example.

Journal Article↗