Search PubMed⌕ Search

Biomedical subjects

A Bassiouny

Publications and source records attributed to A Bassiouny.

10 recordsLinked to original sources
PubMed1986

Broad spectrum antifungal agents in otomycosis.

The in vitro inhibitory activities of four currently used antimycotic agents (clotrimazole, econazole, miconazole and cyclopirox-olamine) against 304 fungal isolates comprising 51 species from 14 genera of moulds and yeasts, using a serial dilution procedure, were studied. Clotrimazole and econazole were found to have a grossly similar broad-spectrum antifungal activity, inhibiting all the tested yeasts and moulds at a concentration ranging from 0.1-4 micrograms/ml. At this range miconazole inhibited 90 per cent of the strains and cyclopirox-olamine inhibited 57 per cent only and thus they were less effective. Econazole 1 per cent solution was very effective in vivo in the treatment of otomycosis within 1-3 weeks. The drug was well tolerated, with no side-effects. Owing to the high broad-spectrum antifungal activity of clotrimazole and econazole, they should be the treatment of choice in otomycosis and can be used safely as otic drops.

Antifungal Agents↗
PubMed1984

'Candida infection in the tongue and pharynx'.

60 patients with chronic pharyngitis were investigated. In all cases the tongue was coated, fissured or hairy. Scrapings from the tongue and swabs from the posteriors pharyngeal wall were examined for the presence of Candida albicans. In the tongue cultures were positive in all cases, and in the pharynx they were positive in 42 cases. After treatment with 'Canasten' solution, the condition was cured in 53 cases. This directs attention to the role of Candida albicans as a cause of chronic pharyngitis, and to the relationship between candidiasis of the tongue and that of the throat.

Adult↗
PubMed1982

Otomycosis: an experimental evaluation of six antimycotic agents.

One hundred-and eight-six fungi were isolated from one hundred-and-eighty cases clinically diagnosed as otomycosis. They comprise 59 species of 26 genera of moulds, and 2 genera of yeasts. This large variety of mould isolates provided ample material for in vitro experiments, to evaluate the anti-fungal activity of six antimycotic substances found in the preparations currently used for the treatment of otomycosis. The antifungal activity of clotrimazole and tolnaftate in vitro was evident. For over 94 per cent of the 59 fungus species tested, the MIC was less than 0.1 micrograms/ml, and for 6 per cent it was between 0.4 and 1 microgram/ml. Concerning the other 4 antimycotic substances (iodochlorhydroxyquin, fluonilid, natamycine and polymyxin B sulphate) the MIC ranged from greater than 100 micrograms/ml to 1 microgram/ml for the majority of tested fungi. The clinical observations were mostly in accordance with these findings.

Antifungal Agents↗
PubMed1982

Non-invasive antromycosis: (diagnosis and treatment).

Increasing numbers of cases of chronic maxillary sinusitis are encountered which resist frequent sinus irrigation and treatment of predisposing factors. The antral washouts are of unusual consistencies and colours. The antral washouts of six cases were investigated by culture and microscopic examination and proved to contain fungal colonies. Antroscopy was a valuable asset in diagnosis. One patient had a Caldwell-Luc operation and daily irrigation through an indwelling polythene tube followed by daily instillation of clotrimazole (Canesten). The five patients who refused operation were treated by repeated bi-weekly antral washouts followed by instillation of clotrimazole. Weekly samples of antral secretions were examined by culture and microscopic examination until they were free for four consecutive weeks. We believe that frequent antral irrigation and local instillation of a broad-spectrum antimycotic drug--preferably after debridement--is the treatment of choice for antromycosis.

Adult↗
PubMed1982

Cryosurgery in cutaneous leishmaniasis.

Thirty patients with cutaneous leishmaniasis were treated with cryotherapy using a CO2 cryomachine and all were cured without noticeable scarring within 4-5 weeks, with no relapse. Histopathological examination showed that cryotherapy eradicated all parasites in less than 1 hour. Leishmania tropica, L. ethiopica and L. brasiliensis are all markedly thermosensitive and thus cryotherapy seems parasiticidal to all types. Adequate cryotreatment of cutaneous leishmaniasis will preclude the development of mucocutaneous extension, and its use in mucocutaneous disease is also recommended.

Adolescent↗
PubMed1982

Maxillary sinus hypoplasia and superior orbital fissure asymmetry.

Misdiagnosis of maxillary sinus hypophasia usually as sinus infection, sometimes as neoplasm, can lead to unnecessary and difficult surgical explorations. Associated anatomical abnormalities, e.g., caudal displacement of the ipsilateral frontal lobe of the brain or central position in the maxilla of the infraorbital nerve may create unexpected surgical hazards. Associated orbital enlargement can lead to diagnostic confusion in the investigation of headache, especially if the superior orbital fissures show marked asymmetry suggesting erosion. Projection of the fissure into the antrum in Waters view can simulate trabeculation of the sinus or fracture of the inferior orbital rim. Radiologic examination of 500 patients without intracranial or intraorbital lesions revealed maxillary sinus hypoplasia in 36 cases (7.2%) and in half the hypoplasia was unilateral (sinus asymmetry); aplasia was not encountered. Fissure asymmetry was present in 30 cases (6%), being present in 3.66% of patients with normally developed sinuses and in 36.1% of the hypoplasia patients. The appearances and measurements of the fissure are presented and examples of marked normal fissure asymmetry are demonstrated. Maxillary sinus hypoplasia is classified in this series as grade I-mild hypoplasia with limited inferolateral expansion (4 cases) and grade II in which there is also a curved orbital floor and lateral displacement of the adjacent nasal wall (32 cases).

Adult↗
PubMed1982

Tonsillomycosis: a myco-histopathological study.

Tissues from 227 tonsillectomies, mainly in adults, were examined culturally and histopathologically for the presence of fungus. Actinomyces was demonstrated in 69 cases (30.40 per cent) by both methods. Yeasts and moulds were each isolated from 21 cases (9.25 per cent) and mixed isolates were obtained from 7 cases (3.08 per cent). There was no histopathological evidence of these organisms. Negative cultural and histopathological results were obtained in 53 cases (23.35 per cent). Chloramphenicol-resistant bacteria were cultured in 56 cases (25.11 per cent) but were seen histopathologically in only 25 cases (11.01 per cent). In all cases in which Actinomyces or bacteria were present histopathologically, a minimal tissue response indicated that these organisms were saprophytes and not primary pathogens.

Actinomyces↗
PubMed1981

Perichondritis of the auricle.

A search of the literature reveals reports of only 191 cases of auricular perichondritis. The present study includes 15 further cases caused by pseudomonas and proteus. Stroud's excision technique was used in four cases and resulted in marked deformity, repeated debridement, and protracted treatment. Tubal drainage was used in the remaining ears with very good esthetic results. It has been demonstrated in experimental animals and in humans that new cartilage forms in the subperichondrial auricular space in the second postoperative week, being maximum in the fourth week. In the present study tubes were retained two to four weeks to maintain an elevation of the perichondrium from what remains of the auricular cartilage to ensure homogeneous cartilage formation and provide local antibiotic treatment. Hospitalization is required for only two days. The four weeks tubal drainage method should be the method of choice for all cases of perichondritis and the excision method abandoned, even in gram-negative infections. A case of relapsing polychondritis is also presented because it is important to distinguish auricular perichondritis from relapsing polychondritis as the treatment of the latter is not surgical but with steroids.

Cartilage Diseases↗