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Biomedical subjects

A Baruchin

Publications and source records attributed to A Baruchin.

At least 37 records · Page 2Linked to original sources

On the histroy of the free skin graft.

Skin graft procedures had already been performed prior to Reverdin's great discovery. Skin grafting apparently originated with the Hindus 3,000 years ago, but until the beginning of the nineteenth century only a few trials were reported. In the first half of the nineteenth century, skin graft procedures were done by Baronio, Cooper, Bünger, and Dieffenbach. Bert's experimental work in 1963 opened the way for the pioneers Reverdin, Ollier, Wolfe, and Thiersch, who contributed the free skin graft.

Animals↗

The vascular response of the "delay" procedure.

Delay of a flap apparently enhances its vitality during later transfer. At the present time, although we have a better understanding of the mechanism of skin flap delay, there are still controversies regarding the details. The purpose of our research was to study the vascular response of the delay phenomenon and compare the results with those obtained by others. This was accomplished by raising and delaying flaps in rats and histologically counting, at regular intervals, the number of arterioles, at a point of 2 cm distally to the base of the flap. Our data shows a decline in the number of arterio-venous shunts, from one week toward the third week post-operatively, thus sustaining those who advocate that the optimum time for transfer after delay procedure, is towards the third week. It is of empiric knowledge that a delay of a flap apparently enhances its chances for survival during later elevation, rotation, and transfer. Hynes (1) suggested that the reason for necrosis in the distal part of the flap is due to the opening of a significant number of arterio-venous shunts. The work of Reinisch (2) contributed to this idea by demonstrating a change in the microvascular circulation in the flap. In this work, an attempt is made to give further proof of Hynes' theory by counting histologically the number of arterioles during the delay period in a flap as an indication of the number of patent arterio-venous shunts.

Animals↗

Pedunculated malignant melanoma.

A malignant melanoma in the form of a pedunculated lesion is so rare that it may not be thought of in differential diagnosis and thus may be overlooked and undertreated.

Arm↗

Vitamin A and corticosteroid interaction in wound healing in rats.

The possible antagonistic interaction of vitamin A and corticosteroids in wound healing was studied in several groups of rats. Follow-up showed that hydrocortisone did not delay wound healing, whereas a long-acting preparation of 6 alpha-methylprednisolone (DEPO-MEDROL) suppressed spontaneous healing of open wounds. Topical application of vitamin A caused a further delay in healing, whereas systemic use of vitamin A had no consistent effect. Since no beneficial effect of vitamin A could be demonstrated, and in view of its possible toxicity, we recommend that the clinical use of vitamin A in wound treatment be reconsidered.

Administration, Oral↗