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Biomedical subjects

A Barrett

Publications and source records attributed to A Barrett.

150 records · Page 9Linked to original sources
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Roller traction: mobilizing patients with acetabular fractures.

Patients with acetabular fractures unamenable to open reduction and internal fixation are subject to 6-12 weeks of traction and, traditionally, bed rest. Using roller traction allows the patient to be mobilized to a bedside chair and to stand without disrupting the traction. This is accomplished by slightly modifying a standard lower extremity skeletal traction setup. Roller pulleys and stopper clamps are substituted for the usual pulleys. These are attached to extra-long horizontal bars that expand the lateral space that the patient can now use around the bed. Roller traction helps prevent the common complications of prolonged bed rest, particularly deep vein thrombosis, skin breakdown, pulmonary stasis and boredom.

Acetabulum↗
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A shoulder to lean on.

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Ambulatory Care Facilities↗
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Diethylcarbamazine: a leukotriene inhibitor. Effects on red cell deformability in-vitro and in-vivo survival during endotoxemia.

Sepsis is associated with alterations in microcirculatory flow which is demonstrated by impaired O2 delivery and extraction by the peripheral tissues. Leukotrienes, derivatives of arachidonic acid, have been implicated as mediators of the septic process. We investigated the effect of diethylcarbamazine (DEC), a leukotriene inhibitor, on the flow of endotoxin-treated blood through a 5-micron pore polycarbonate filter and on survival in a model of intraperitoneal rat endotoxemia. Endotoxin alone significantly impaired red blood cell flow through the filter. This effect was reversed with DEC treatment. In addition, treatment with DEC significantly reduced rat endotoxemia mortality. This study indicates that impaired red cell deformability may be one factor involved in the alterations in microcirculatory flow following sepsis. Leukotriene inhibition, with DEC improves red cell deformability in vitro, and may account, in part, for the improved survival seen in rat endotoxemia.

Animals↗