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Biomedical subjects

A Barret

Publications and source records attributed to A Barret.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Von Willebrand factor activity and thrombophilic states. A review (author's transl)].

After a brief survey of some physiologic properties of Von Willebrand factor activity (VIII r WF) the numerous clinical states with an increase of this activity are described. The authors report their own results concerning sepsis, chronic arteritis of lower limbs, diabetes, toxemia of pregnancy. In most cases the increase of VIII r WF activity appears as a sign of vascular injury and/or the consequence of tissular damage.

Arteriosclerosis↗
PubMed1976

[Aneurysms, late complications at the level of anastomosis of an arterial bypass].

The authors report 12 cases of aneurysm occuring in anastomoses in 9 operated patients. The delay of onset of these lesions was long, 9 years on average. The fraquency appears low, slightly greater than 1 p. 100 in all arterial plastic operations. Among the 10 treated lesions half were false aneurysms due to breakdown of the suture and half were true aneurysms due to progression of the arterial dystrophy. All cases were treated by dissection and insertion of a new prosthesis between the old prosthesis and a healthy area, beyond the anastomosis. Out of 9 patients, there were 8 good immediate results and one failure due to infection at the level of the prosthesis. Among the various methods of prevention, avoiding infection may be the most important.

Age Factors↗
PubMedDate not supplied

Possible role of neuropeptide degrading enzymes on thyroliberin secretion in fetal hypothalamic cultures grown in serum free medium.

In the present work, we have looked for the presence of two tissular neuropeptide degrading activities, the pyroglutamate aminopeptidase (PAP) and the post-proline cleaving enzyme (PPCE), in dissociated brain cell cultures. These two activities are present in extracts of cells grown in serum-free medium and are detected at a very low level in incubation media. Depolarization of hypothalamic neurons by 60 mM K+ does not specifically increase the level of PAP and PPCE in the medium. We have also used an inhibitor of PPCE: Z-Gly-ProCHN2. This compound can be left in contact with living cells without any toxicity, and in certain conditions of incubation blocks totally and irreversibly both PAP and PPCE. This blockade results in increased levels of TRH, intracellular as well as released into the medium, spontaneously and upon K+ depolarization. These results evidence the role of degradation processes in the mechanisms regulating peptide turn-over.

Aminopeptidases↗
PubMedDate not supplied

[Lumbar sympathectomy].

The authors undertook a study of the present indications for lumbar sympathectomy in cases of obliterating arteriopathy of the lower limbs. The principal physiological effects are described in addition to its action on the circulation. Apart from the opening of arteriovenous shunts, the lifting of the precapillary block should be emphasized since this increases the flow and consequently leads to the development of the collateral circulation. A recent experiment over a period of three years involving 457 hospitalized patients is then analysed: out of 371 conservative operations performed, 169 involved restorative arterial surgery and 202 involved only lumbar sympathectomy. Lumbar sympathectomy was combined with the arterial surgery in 150 of the 169 cases quoted above. Lumbar sympathectomy alone is required in stages III and IV when arterial is not possible. At stage II, there is a choice, sympathectomy being preferred to direct surgery. The results are analysed and the best were obtained with patients at stage II.

Arterial Occlusive Diseases↗
PubMedDate not supplied

[Inter-related arterial and venous pathologies].

The authors concomitant arterial and venous disorders. On the same patient. They point out the obvious preeminence of arterial disease on venous ones, and discuss about the panel of therapy association usable. They underline the necessity of saving the venous capital.

Arteries↗
PubMedDate not supplied

[Axillary-subclavian venous thrombosis. Therapeutic management].

24 cases of axillary-subclavian venous thrombosis were studied according to the etiology: "intrinsic" thrombosis secondary to alteration of the endothelium (7 cases), "extrinsic" thrombosis secondary to compression at the level of the thoracic outlet (4 cases), "combined" thrombosis following a complex treatment of breast cancer (3 cases). The frequency of these thromboses, undoubtedly underestimated, seems low as compared to that of venous thromboses of the lower extremities. The frequency of pulmonary emboli is 8%. The treatment is limited to anticoagulants in case of intrinsic or combined thrombosis. In the third type, decompressive surgery is necessary, especially if there are abnormalities of the cervico-dorsal junction or associated neurological or arterial disorders.

Adult↗
PubMedDate not supplied

[Iatrogenic injuries of the venous femoroiliac axis].

The occurrence of iatrogenous vascular accidents is underestimated. The authors describe 14 venous lesions to the femoro-iliac axis out of 60 iatrogenous vascular traumatisms. They consider the different aetiologies, underlining the disadvantages of femoral catheterisms and the main surgicalfactors contributing to venous traumatism. They emphasize the need for preventive measures in each discipline, and also the need for rapid diagnosis, thorough treatment, and careful post-operative after-care, bearing in mind secondary thrombo-embolic complications.

Adult↗