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Biomedical subjects

A Barrera

Publications and source records attributed to A Barrera.

At least 37 records · Page 2Linked to original sources

Complications of super-selective subarachnoid anesthesia (SSA) with hyperbaric bupivacaine: experiences with 355 patients in general and orthopaedic surgery.

The results obtained from 355 patients of both sexes subjected to general and orthopaedic surgery with super-selective subarachnoid anesthesia (SSA) by means of small (26-27 gauge) needles with a modified Whitacre needle with ogival point are described. The use of thin spinal needles with "pencil-point" type ends together with microdoses of local anesthetics has meant a reduction in the complications typical of this technique such as hypotension, post-dural puncture, headache (PDPH) and urinary retention. Super-selective subarachnoid anesthesia realised through an infusion of 0.8-1 ml of hyperbaric bupivacaine is a safe effective technique with a low percentage of side-effects.

Adolescent↗

[DNA identification of human papillomavirus in anogenital condyloma of a male population].

Human Papillomaviruses (HPV) are the cause of benign human anogenital lesions where HPV 6 and HPV 11 are most commonly found. Conversely, HPV 16, 18, 31 and 33 are frequently detected in genital carcinomas and are thus considered as oncogenic types. In order to analyze the prevalence of specific HPV types in an Argentine male population, 43 anogenital lesions from different patients with diagnosis of condyloma acuminata were analyzed. These lesions were localized in different regions of the male genitalia comprising the corona glandis, urethral meatus, skin of the penis, scrotum and anus. The biopsies were screened for the presence of HPV 6, 11, 16, 18, 30, 31 and 33 by Southern blot at different stringent conditions of hybridization (Tm -48 degrees C and Tm -20 degrees C). HPV DNA was found in 41 examined cases (95.3%) with a clear prevalence of HPV 6 and HPV 11 types (51.2% and 23.3% respectively). Six samples (14.0%) were positive only under nonstringent conditions of hybridization. Mixed infections between HPV 16, 18, 30, 31, 33 or a HPV 30 related type with HPV 6 or HPV 11 were detected in 8 specimens (18.6%). Only one case was between HPV 16 and HPV 30. Two additional samples were only positive for HPV 30. Experiments in progress about the prevalence of HPV types in female lesions as well as in normal subjects will contribute to complete the description of the epidemiology of these infections in Argentina.

Adult↗

[Suicide attempt and hopelessness].

Suicidal subjects can be divided into those who think about suicide, those who attempt it and those who complete it. Since any suicidal manifestation is a potential risk this classification can also be treated as a continuum of increasing severity. This paper reports on the relationship between the psychological dimension of hopelessness and factors such as suicidal ideation, depressiveness, suicide attempt and attempt repetition. Data from 63 female patients with a recent suicide attempt from an ambulatory psychiatric service in Santiago South were clinically and psychometrically evaluated by means of appropriate instruments. Hopelessness correlated positively with severity of depression, number of previous attempts, current suicidal ideation and suicidal intent. Hopelessness score of 11 or more were frustrated by survival and were ambivalent. The mediating role of hopelessness between depression and suicidality is stressed.

Adult↗

[Pericardial tamponade and systemic sclerosis].

We report a case with systemic sclerosis (scleroderma) presented with an acute pericarditis and pericardial tamponade with haemodynamic impairment that required pericardial drain. The frequency of pericardial disease in scleroderma is high, but the clinical recognition is rare, and tamponade with haemodynamic impairment requiring aspiration for relief is exceptional, but should be considered in patients with scleroderma that present an acute pericarditis. It is suggested that pericardial fibrosis in scleroderma may predispose to pericardial tamponade.

Acute Disease↗

[Is there an etiopathogenic relationship between diabetes mellitus and chronic diffuse hepatopathy?].

Standard biochemical studies to rule out Diffuse Hepatopathy are performed in 60 diabetic patients in different grades of compensation, having no previous hepatic disease. In order to determine the degree of glucemic compensation, Glicosilated Haemoglobin A1C was analyzed. None of the studied parameters showed statistical difference between the four studied groups (DID, NIDD, compensated versus non compensated), indicating that the specific diabetic heatopathy does not exist. We conclude that the hepatotrophic effect of insulin could be related to previous hepatic lesiones, having no influence when the liver architecture is preserved.

Adult↗

Survival of transferred intestinal segments after vascular pedicle interruption.

Rat intestinal segments with intact vascular pedicles were transferred from the abdominal cavity into the subcutaneous space. After 30 days, the vascular pedicle was severed. The intestinal segments, now completely dependent on wound neovascularization, survived completely. We conclude that early survival of intestinal transfers requires perfusion through the vascular pedicle. With time in a favorable bed, new vessel ingrowth from the recipient wound into the intestinal segment provides adequate circulation so that the vascular pedicle can be safely divided with no ill effect or at most a minor mucosal slough which quickly heals. Further clinical opportunities are necessary to determine the time course for these phenomena in humans.

Animals↗

Infusion tomography of the gallbladder.

Infusion tomography of the gallbladder has proved to be more specific in the detection of pathologic disease as compared with conventional roentgenologic examinations by showing the wall of the organ instead of the contents. Infusion tomography of the gallbladder has been a useful initial procedure in patients with acute cholecystitis and in those with obstructive jaundice. It has helped to confirm diagnosis in patients with chronic lithiasic cholecystitis and nonvisualized gallbladder or with gallstones with documented on oral or intravenous studies. Infusion tomography of the gallbladder can be done on an emergency basis; it requires no prior preparation of the patient and usually yields an answer within 30 minutes. No significant complications have resulted from the high dose of iodized contrast material. There have been only two false results, one negative and one positive, so the procedure can be regarded as a highly reliable one.

Adult↗

Early clinical and surgical results of biliopancreatic diversion.

BACKGROUND: Scopinaro biliopancreatic diversion (BPD) for morbid obesity results in significant longterm weight loss and reduction or resolution of obesity-associated co-morbidities. The aim of our work was to describe the early results after BPD. METHODS: 59 morbidly obese patients (BMI >40) underwent open BPD from December 2001 to December 2004. We analyzed a consecutive series of 19 patients who have been followed >4 months. We present the data of basal and early visits (2 and 4 months). RESULTS: Initial excess weight percent loss (IEW%L) was 5.2% at 2 months and 13.7% at 4 months. Glycemia, cholesterol, triglyceride levels and blood pressure improved at each visit. All parameters have significant differences from the basal values. 3 patients had sleep apnea syndrome, and overnight CPAP was able to cease in 2 patients by 4 months. 6 patients (31.5%) had albumin <2.5 g/dl, without clinical findings of malnutrition. Total calorie (857+/-79.8 cal/day) and protein (59.8+/-23 g/day) intakes at 4 months were low, with a low intake of multivitamins and oligoelements from food. There was no mortality in this series. Early postoperative morbidity was incisional hernia (21.1%), anastomotic leak (5.2%), wound infection (15.7%), intra-abdominal infection (5.2%), and intestinal obstruction (5.2%). CONCLUSION: BPD showed early effectiveness in weight loss and co-morbidity improvement. Calorie, protein, oligoelement and vitamin dietary intakes were below recommendations, so that strict multidisciplinary follow-up and supplementation to prevent or treat nutritional deficiencies are mandatory.

Adult↗

[Psychosis as the initial manifestation of systemic lupus erythematosus: the role of lupus band test and anti-ribosomal antibodies].

INTRODUCTION: Diffuse brain disease in systemic lupus erythematous (SLE) can be difficult to assess because of the sparse biological expression of the disorder, resulting in usually normal neuroimaging and laboratory findings. For this reason, it is likely that patients without a previous SLE diagnosis that presented initially with a pure psychiatric disorder, as psychosis or depression, can remain undiagnosed, and, in fact, they are exceptionally reported. As a biological marker, antiribosomal P protein antibodies have been closely related to SLE psychosis although their pathogenic role and specificity is under discussion. CLINICAL CASE: A young woman, without relevant medical history, presented with an acute psychotic catatonic picture, suspected organic in nature due to the existence of persistent mild CSF pleocytosis, while neuroimaging and laboratory studies were negative, including antinuclear and antiribosomal antibodies. Finally, a SLE diagnosis could be established because of a strong lupic band phenomenon in skin biopsy. CONCLUSIONS: It is important to maintain a high suspicion of SLE in acute psychotic patients, especially if atypical features are present. As the biological expression of the disorder in such cases may be elusive, we propose the study of lupus band in skin biopsy for these patients, regardless the absence of antiribosomal antibodies.

Adult↗

[The influence of personality on suicidal behavior].

With the purpose of studying the influence of personality on suicidal behavior, 63 female suicide attempters were assessed by means of standardized interviews, Eysenck's personality questionnaire (EPQ-R) and other psychometric scales. Personality disorders (DMS III-R) were found in almost 70 per 100 and associated with previous attempts, higher hopelessness, suicide ideation, and to a more severe attempt. The most relevant dimensions were psychoticism and extraversion. The first one correlated to repetition, hopelessness, and suicide ideation; the second exerted a moderating effect, showing association with feelings of conformity towards survival. Neuroticism showed a rather unspecific effect on studied factors. Results confirm a relationship between personality disorders and suicidal behavior, and suggest possible mediating variables.

Adolescent↗