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Biomedical subjects

A Barr

Publications and source records attributed to A Barr.

At least 55 records · Page 3Linked to original sources
PubMed1986

Neuroradiological and electroencephalographic features in a case of temporal lobe status epilepticus.

A patient with medically intractable status epilepticus of temporal lobe origin is presented. A computed tomogram showed a low density area adjacent to the midbrain, possibly related to atrophy of the medial temporal lobe. Cerebral angiography revealed early filling veins and an anterior temporal blush. Magnetic resonance (MR) scanning (T2 weighted images) showed increased signal intensity in the region of the amygdala and anterolateral left temporal lobe. Ictal activity was recorded from scalp electrodes over the left temporal area, and many paroxysms were recorded from cortical surface electrodes. An anterior temporal lobectomy revealed only gliosis. The cerebral blood flow changes accompanying status epilepticus of focal origin are reviewed, and a possible relation of electroencephalographic, angiographic, and MR findings is discussed.

Adult↗
PubMed1985

Recurrence of childhood multiple tic in late adult life.

In contrast to the lifelong persistence of symptoms characteristic of Gilles de la Tourette's syndrome, multiple tic of childhood is considered to be a self-limited disorder that remits by early adulthood. We describe four patients who had a history of multiple tic of childhood, complete absence of tics throughout most of their adult lives, and recurrence of tics in late adult life. All four had multiple tics that began before the age of 9 years and included both motor and vocal tics that changed in location and severity over time. None of the patients exhibited coprolalia. All tics subsided before the age of 20 years, only to recur after the age of 60 years, once again including both motor and vocal tics that changed in location and severity slowly over time. The one patient who was severely bothered by the recurrence of motor and vocal tics responded well to haloperidol. Although they do not fit into any accepted diagnostic category for multiple tic, these patients suggest that multiple tic of childhood can recur in adult life. This suggests that Gilles de la Tourette's syndrome may be a continuum for chronic multiple tic of childhood to full-blown classic Gilles de la Tourette's syndrome.

Age Factors↗
PubMed1984

The reversibility of "permanent" tardive dyskinesia.

Neuroleptic-induced tardive dyskinesia (TD) that persists for 1 year or more following withdrawal of neuroleptics is usually said to be permanent. Early spontaneous remissions have been well described but most such remissions occurred within the first few months following neuroleptic withdrawal, and no published studies have followed patients for more than 2 years to evaluate permanence of remission. Over the last 12 years, we studied six patients with TD who, on prolonged follow-up, were found to have complete remission of their abnormal movements after a neuroleptic-free period of more than 2 years (2 1/2-5 years). All six patients were 61 years old or younger when their TD was diagnosed and their neuroleptics withdrawn. In five of the patients, remission occurred while the patients were not taking medication for the movements, while one patient had been on long-term, high-dose (2 mg/day) reserpine therapy for more than 3 years. The incidence of late remission of TD is not known and cannot be estimated from these selected patients, but these cases demonstrate that persistence of abnormal movements of TD for 2 or more years following neuroleptic withdrawal does not imply permanence in all patients. We suggest that TD be considered a persistent rather than an invariably permanent disorder.

Adolescent↗
PubMed1982

Estrogen treatment of dyskinetic disorders.

Estrogen have been reported in animal studies to both enhance and block central dopaminergic activity and in one clinical report to improve tardive dyskinesia. In the present study estrogen (Premarin, 2.5 mg per day) administration caused varying degrees of improvement in less than one-third of 21 patients with chorea due to Huntington's disease and tardive dyskinesia and had no effect in eight patients with dystonia. Estrogens appear to have an antidopaminergic effect in humans but poses only limited efficacy in the treatment of dyskinetic disorders.

Adult↗