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Biomedical subjects

A Baron

Publications and source records attributed to A Baron.

At least 145 records · Page 8Linked to original sources

Increased reinforcement when timeout from avoidance includes access to a safe place.

Three experiments investigated the reinforcing value of access to a safe place during timeout from an avoidance schedule. Rats were trained on conjoint schedules in which responding both postponed shock on a free-operant avoidance schedule and produced periods of timeout on fixed-ratio schedules. In some conditions, a shelf was inserted into the operant chamber during timeout, enabling subjects to get off the grid floor. The combination of timeout and shelf maintained substantially higher response rates than the baseline avoidance schedule with ratio requirements as high as 90 (Experiment I). Adding the shelf to timeouts in one component of multiple fixed-ratio schedules of timeout resulted in higher response rates in the component where the shelf was included (Experiment II). When timeouts with and without the shelf were arranged on concurrent schedules, the shelf-timeout combination was preferred, even when of shorter duration than timeout alone (Experiment III). In all three experiments, subjects climbed on the shelf, although all shocks were cancelled during timeout periods. The results could not be accounted for solely in terms of the reinforcing properties of changes in shock rates, but required an interpretation that ascribed conditioned reinforcing value to stimuli associated with such changes.

Journal Article↗

[Combination chemotherapy in the treatment of polymetastic breast cancer. Comparison of therapeutic effects of 2 methods of sequential drug administration. Role of adriamycin in these combinations].

One thousand and twenty four patients with disseminated breast cancer were submitted to combination chemotherapy. Fifty one patients (group I) were sequentially given VCR, CPM and 5 FU, and seventy three patients (group II) were given ADM, VCR, CPM and 5 FU. The general and haematological tolerance was good and comparable in the both groups of patients: we observed only two severe infectious complications. Bonemarrow hypoplasia, six myocardial ischemia (two of them were lethal) in each group of patients, without any predominance in the group of patients treated with adriamycin. The percentage of objective regression in both groups was respectively: 72% and 71%. The mean duration of response was eight months. The median survival time was 420 days for patients of group I; for patients of group II the median is not obtained at 480 days. This study confirms that responders to chemotherapy significantly increase the mean duration of survival time. However, in this group of responders the presence of the liver metastases is worse prognosis than all other visceral metastases.

Adenocarcinoma↗

[Correlation between immunological stage and response to chemotherapy. Results in 64 patients with nonresectable epidermoid bronchial cancers].

Out of 64 patients with non resectable epidermal bronchus carcinoma, 26 patients had before any treatment positive responses of skin tests to recall antigens. In these patients we found a correlation between the reactivity of the skin tests, the presence of seric factor inhibiting the leucocyte migration, the mean count of peripheral lymphocytes and the response to combination chemotherapy protocol. The patients who respond to treatment have a significantly better prognosis than the patients who do not respond. With this correlation it seems to be possible to distinguish between two populations of patients with non resectable bronchus carcinoma : one population with a good risk who can be significantly improved by the treatment : the other population with a very severe prognosis.

Adrenal Cortex Hormones↗

Clock control of human performance on avoidance and fixed-interval schedules.

The avoidance and fixed-interval performances of human subjects were studied in two experiments. Addition of time-correlated stimuli (added clock) improved behavioral efficiency, since response rates decreased without decreases in reinforcement rates. Response-dependent display of the clock maintained a second, observing response and reductions in clock duration weakened such observing behavior. Generally, the reinforcing properties of the clock were more apparent with the avoidance than with the fixed-interval schedule, a finding attributed to temporal cues already provided by delivery of the fixed-interval reinforcers. Reduced rates of the main response when the clock was dependent on an observing response were more than offset by rates of the observing response in the majority of subjects. Thus, the results do not support an interpretation of the reinforcing properties of added clocks simply in terms of work reduction.

Journal Article↗

[Chemotherapeutic combinations of mutually potentializing drugs. 1-Application to the treatment of breast cancers].

27 patients suffering from disseminated carcinoma of the breast with at least two visceral metastases, and two had become resistant to conventional chemotherpy and hormones, received a combination of, in the present trial, vincristine followed by cyclophosphamide with 5-fluoro-uracil. Chemotherapy was administered intermittently: each cycle of treatment lasted 6 days and was followed by a period without treatment of 25 days. Haematological tolerance was satisfactory. No serious incidents occurred during two years use of the combination. 20 out of 27 patients showed objective tumour regression of more than 50 p.cent lasting for more than 6 months, whilst 9 showed apparent complete regression of the malignant lesions. There was one complete failure. Chemotherapy was continued in all cases after regression of the neoplastic process was obtained.

Aged↗

[Chemotherapeutic combinations of mutually potentiating drugs. 2-Application to the treatment of bronchial cancers].

16 patients suffering from primary bronchial tumours which had recurred after surgery and/or radiotherapy and with spread involving at least one visceral or lymphatic metastasis received chemotherapy consisting of the administration of vincristine followed by a combination of CCNU and 5-fluorouracil. Each cycle of treatment lasted 6 days and was restarted only after an interval of 30 days on average, this being necessary for haematological recovery. With the doses of CCNU used, thrombocytopaenia occurred only during the fifth cycle of treatment and made it necessary to increase the interval between subsequent courses to five weeks. All of the patients included in the study have now been followed up for between six and eighteen months. Two patients are presently in complete remission without apparent radiological, clinical or bronchoscopic signs. In seven other patients there was tumour regression greater than 50 p.cent persisting for four to six months. In seven, the therapeutic effect was transient or nil.

Adult↗

[Chemotherapeutic combinations of mutually potentiating drugs. 3-Application to primary tumors of the central nervous system].

17 patients suffering from primary tumours of the central nervous system recurring after surgery and/or radiotherapy, received chemotherapy consisting of the administration of VM 26 followed by CCNU. Each cycle of treatment lasted four days and was restarted only after an average interval of 30 days to allow for haematological recovery. All of the patients in the trial have been under treatment for eight months. Five (28 p.cent) are at present in complete remission with no residual clinical, isotopic or radiological signs. In six others there was tumour regression and in four neurological stabilisation. In all those cases where objective tumour regression was obtained functional improvement was noted.

Adolescent↗

A rate measure of the relative aversiveness of signalled vs unsignalled shock.

Five rats were trained on a two-component multiple schedule with each component consisting of a two-link chain schedule. Differential response suppression in the initial links of the chain schedules was used as a measure of the relative aversiveness of events introduced into the subsequent terminal links. When unsignalled shock was scheduled in one terminal link and signalled shock in the other (in addition to equal numbers of food reinforcers), responding was suppressed to a greater degree in the initial link preceding the unsignalled-shock condition. Reversing the terminal-link positions of unsignalled shock and signalled shock led to a reversal of the differential response suppression in the initial links. These results confirm previous findings that signalled shock is less aversive than unsignalled shock and extend the generality of this phenomenon from choice measures to rate measures of aversiveness.

Journal Article↗