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Biomedical subjects

A Baglin

Publications and source records attributed to A Baglin.

At least 55 records · Page 3Linked to original sources
PubMed1986

Plasma free, sulfo- and glucuro-conjugated catecholamines in uremic patients.

The metabolism of catecholamines (CA) in non-selected patients with chronic renal failure and under hemodialysis (CRFh) was studied by measuring the concentration of plasma free, sulfo- and glucuroconjugated CA, dopamine (DA), norepinephrine (NE), and epinephrine (EPI). Our data demonstrate a statistically significant increase of free DA and free NE concentration in CRFh, while that of free EPI was not different from controls. However a careful scrutiny of 35 individual data suggests that sub-groups of patients with either high normal or low plasma-free NE concentration could exist; this likely heterogeneity could be a good explanation for conflicting conclusions provided by previous reports. Suspecting that conjugated CA might be altered in CRFh, plasma sulfo- and glucuro-conjugated DA, NE and EPI were also measured. We have found a predictable and highly significant increase of sulfo-conjugated CA; plasma concentration of glucuro-conjugated DA and NE in CRFh was not different from controls, while that of glucuro-conjugated EPI was significantly increased. The physiological meaning, if any, of these new observations on conjugated CA cannot be assessed at the moment. The effects of hemodialysis were also investigated. Measurements on the arterial and on the venous line showed highly significant differences for tyrosine, free and sulfo-conjugated CA, and a lack of difference for glucuro-conjugated CA. Thus tyrosine, free and sulfo-conjugated CA were eliminated by the artificial kidney, but not glucuro-conjugated amines.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

[Plasma catecholamines, free and conjugated, in the hemodialyzed chronic renal failure patient].

Free, sulfo and glucuro-conjugated catecholamines (dopamine, noradrenaline and adrenaline) were measured to study their metabolism in 35 non-selected patients with chronic renal failure, and under hemodialysis for various periods of time. Our data demonstrate a statistically significant increase of free dopamine, and free noradrenaline concentration in these patients, while that of free adrenaline was not different from controls. However a careful scrutiny of 35 individual data suggests that sub-groups of patients with either high normal or low plasma free noradrenaline concentration could exist; this likely heterogeneity could be a good explanation for conflicting conclusions provided by previous reports. Suspecting that conjugated catecholamines might be altered in these patients, plasma sulfo and glucuro-conjugated amines were measured. We have found a predictable and highly significant increase of sulfo-conjugated catecholamines; glucuroconjugated dopamine and noradrenaline were unchanged, while glucuroconjugated adrenaline was significantly increased. The physiological meaning, if any, of these new observations on conjugated catecholamines cannot be assessed at the moment.

Adult↗
PubMed1986

[Syndrome of alveolar hemorrhage associated with systemic cholesterol embolism].

Vascular purpura and haemoptysis developed in a patient suffering from accelerated hypertension and rapidly progressive renal failure due to cholesterol embolism. Alveolar haemorrhage was diagnosed on the association of clinical and endoscopic results, and on the outcome of the disease. This syndrome is usually associated with other immunological disorders and raises the question of immunological phenomena being the cause of some of the clinical manifestations observed after cholesterol embolism.

Acute Kidney Injury↗
PubMed1986

[A systemic-like disease: chronic vitamin A poisoning].

A 22-year-old man, had ingested more than 300 10(6) I.U. of vitamin A over a 2-year period. He presented with diffuse arthralgia, weight loss, low-grade fever, dryness and peeling of the skin, hair loss, liver enlargement with ascites and pleural effusion. He had a raised E.S.R., hypercalcemia and acute renal failure. Plasma levels of vitamin A and retinol-binding-protein were in the normal range. All symptoms disappeared after withdrawal of vitamin A except for the liver enlargement. Iliac bone biopsy showed cortical thickening, numerous resorptive lacunae and no index of bone formation. Liver biopsy showed obliteration of the space of Disse by swollen fat-storing cells (Ito cells). Tissue levels of vitamin A were very high in the liver. A second biopsy, 6 months later, showed a decrease of fat storage in the Ito cells but the development of a fibrosis.

Adult↗
PubMed1985

Pharmacokinetics of cibenzoline in patients with renal impairment.

Pharmacokinetic values of cibenzoline, a new, investigational, antiarrhythmic drug, were determined in 13 patients with varying degree of renal impairment, creatinine clearance range between 5 and 53 mL/min. Cibenzoline plasma levels were measured after direct intravenous injection of one single 1 mg/kg dose. The apparent volume of distribution of the drug (276 1) was similar to that reported in healthy subjects. Total body clearance decreased with creatinine clearance, and there was a close correlation between cibenzoline renal clearance and creatinine clearance (r = 0.956; P less than 0.001). Plasma elimination half-life was prolonged, with values ranging from 7:4 to 23.6 hours. This study showed that cibenzoline total body clearance correlated with the degree of renal impairment, and it is suggested that in patients with chronic renal failure dosage should be adjusted according to creatinine clearance values.

Adult↗
PubMed1985

[Choriocarcinomatous neoplastic pulmonary embolism. A case].

Massive obstruction of the right branches of the pulmonary artery by choriocarcinomatous cells was found at embolectomy in a 36 year old woman who had had a hydatidiform mole 10 years previously. Several febrile lung infections resistant to antibiotic therapy over an 11 months period, had led to a reduction in the volume and vascularisation of the right lung. The diagnosis of recurrent pulmonary embolism was only suspected when a further embolic episode occurred after curettage for a spontaneous abortion at 9 weeks of pregnancy. The diagnostic value of increased HCG was masked by the pregnancy. The patient died a few days after surgery despite administration of chemotherapy postoperatively. The authors discuss the problems in the diagnosis of recurrent pulmonary embolism in the absence of a suggestive cause and the problem of detecting the tumoural nature of these emboli.

Adult↗
PubMed1983

[Glomerulopathies in the aged (excluding diabetes)].

Fifty-five cases of glomerular disease in non-diabetic patients above sixty years of age were studied retrospectively. Primary glomerular disease was found in 36 cases, among which 14 cases with minimal changes glomerulopathy (25.4%) and 7 cases with membranous glomerulopathy (12.7%). The remaining 19 patients had secondary glomerular disease, mainly with amyloidosis (12 cases: 21.8%). In these three main forms of glomerulopathy, symptoms were similar, making differential diagnosis impossible before histological examination. Significant responses to treatment can be achieved in minimal changes and extracapillary proliferative glomerulopathies: among the 14 patients given corticosteroids, 9 recovered or experienced very significant improvement. However, one patient under cortico-steroids died from perforation of the sigmoid. In order to establish the best treatment, investigations should be carried out as in younger patients, since they do not seem to involve a significantly higher risk.

Adrenal Cortex Hormones↗
PubMed1983

[Decrease of the 3rd fraction of serum complement. Study in a hospital population of 13000 patients].

Patients with serum concentrations of C3 lower than 0.40 g/l among 13 000 patients in a general hospital seen over an 18 months period were studied. 95 cases were eligible for study. Diffuse and severe liver disease accounts for 50% of cases. Immunologic diseases represent little more than 10% of cases. The other common causes are severe infections and nutritional deficiencies. Besides the immunological diseases, low C3 serum concentration represents a poor prognosis factor since 55% of patients died during hospitalization.

Complement C3↗
PubMed1983

[Sarcoidosis disclosed by renal insufficiency (3 cases)].

Sarcoidosis was found in three patients referred for etiologic diagnosis of chronic or rapidly progressive renal failure. One patient presented as an isolated interstitial nephropathy and renal biopsy showed granulomatosis. The two other patients had hypercalcemia. In one, hyperparathyroidism was discussed and cervicotomy disclosed a sarcoidosic adenopathy. Under corticosteroid therapy, renal function improved in each of the three patients. It is pointed out that accurate diagnosis of this setting is of significance since effective therapy is possible.

Adrenal Cortex Hormones↗
PubMed1983

[Pseudocoarctation caused by a calcified intra-aortic mass].

Weak or absent lower limb pulses and a thoracic systolic murmur in a fifty-seven-year-old woman with hypertension suggested coarctation. Thoracic X-Ray showed a narrowing of the thoracic aorta over 10 cm due to an intraluminal calcified aortic mass. The remaining aorta and its branches were normal. Histologic examination of the operative specimen found atherosclerotic lesions with thrombosis. This very unusual condition seems to represent an individual entity of which a few cases have been reported in the literature.

Aorta, Thoracic↗
PubMed1983

[Acute ischemia of the lower limbs in nephrotic syndrome in a young woman].

A thirty-year-old woman, who had onset of nephrotic syndrome during the last part of her pregnancy, experienced recurrent acute ischemia of both lower limbs, leading to three conservative surgical procedures one month after delivery. Investigations disclosed no cause of embolism and were suggestive of thrombosis. The arteriography showed a diffuse reduction in diameter of the aorta and iliac vessels without localised stenosis or other vascular lesions. This complication is presumably related to several factors associated with the reduction in arterial diameter: hypovolemia, hyperfibrinemia, hyperlipidemia and abnormalities of hemostasis.

Acute Disease↗
PubMed1983

[Pericarditis with recurrent cardiac compression in rheumatoid polyarthritis].

The authors report the case of seventy-two-year-old man with severe rheumatoid arthritis in whom onset of right ventricular failure led to the discovery of pericarditis. After fluid withdrawal, the anterior part of the pericardium was resected. Analysis of the fluid and histological findings suggested a rheumatoid origin. Pericarditis recurred two and a half years later causing subacute compression of the heart leading to repeated centeses in spite of corticosteroid therapy. In the terminal stage, M. tuberculosis was discovered but this finding was not confirmed subsequently. The main features of rheumatoid pericarditis are reviewed. Tuberculous pericarditis should be considered in patients under corticosteroids or immunosuppressive agents.

Aged↗
PubMed1983

[Intermittent claudication disclosing amyloidosis in a chronically hemodialysed patient with light-chain myeloma].

The occurrence of amyloid deposits in skeletal muscle and its vessels has been noted from a long date in amyloidosis. However, their clinical manifestations have been seldom noticed. The authors report the case of a patient with light-chain myeloma in which an arterial intermittent claudication led to the discovery of muscle vascular amyloid deposits. Muscle signs and symptoms due to amyloidosis and their mechanisms are reviewed.

Amyloidosis↗
PubMed1983

[Natriuretic effect of haloperidol in dogs].

A 0.5 microM/kg/min infusion of haloperidol in the renal artery of 20 sodium-loaded dogs undergoing water diuresis is showed to induce the following net effects: a statistically significant reduction of both clearance of PAH (-18.1 +/- 6.6 ml/min), and glomerular filtration rate (-4.3 +/- 1.5 ml/min), an increase of both fractional excretion of sodium (+ 6.8 +/- 1.1%) and potassium (+ 55.1 +/- 5.5%), a decrease of fractional excretion of phosphate (-5.3 +/- 1.5%), and a lack of change of free water clearance (infused minus controlateral kidney difference).

Aminophylline↗
PubMed1982

[Renal effects of chlorpromazine in dogs].

The renal effects of chlorpromazine (CPZ) were studied in sodium-loaded dogs. Intrarenal artery infusion of CPZ at 0.2 microM/kg/min induces a significant decrease of both clearance of PAH and GFR, with no measurable effect on the excretion of electrolytes. This result is interpreted as direct evidence in favor of a physiological role of dopamine, since CPZ is known to be a dopaminergic blocking agent. At 2.0 microM/kg/min, CPZ no longer induces a renal hemodynamic alteration, but has a powerful natriuretic effect associated with an increased kaliuresis, and an increase of the free water clearance; phosphate excretion was unchanged. This effect on the excretion of electrolytes is apparently reversible within the 30 minutes immediately following the discontinuation of the CPZ infusion. The CPZ-induced natriuresis and kaliuresis are not additive to aminophylline's, suggesting a renal cyclic nucleotide phosphodiesterase inhibition. In conclusion, CPZ has a dose-dependent effect on dog kidney: it induces a reduction of the renal hemodynamics at a low dose, and an inhibition of the tubular sodium transport at a high dose.

Aminophylline↗