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Biomedical subjects

A Badia

Publications and source records attributed to A Badia.

80 records · Page 5Linked to original sources
PubMed1975

Nature of neuronal uptake and noradrenaline--adrenaline effects in the isolated rat vas deferens.

Uptake mechanisms in the rat vas deferens have not yet been thoroughly investigated. In this study we show that uptake inhibition by cocaine, amantadine and desmethylimipramine induces increases in sensitivity that are greater for adrenaline than for noradrenaline. However, this does not occur when guanethidine is used. These results are clearly in disagreement with the neuronal uptake hypothesis. Uptake mechanisms in the rat vas deferens may be different from those of other tissues.

Amantadine↗
PubMedDate not supplied

[Survival of women with breast cancer in a hospital-based registry (1979-1991)].

We analyzed the survival of 268 women diagnosed with breast cancer between 1979 and 1991, registered at the Tumour Registry of the Hospital S. Jaume i Sta. Magdalena, Mataró (Barcelona). Relative survival rates at two, five and ten years were 0.84, 0.69 and 0.49, respectively. The largest difference in survival was observed in relation to the stage at the time of diagnosis. The survival was worse in women aged between 30 and 39 years and between 80 and 89 years. No significant differences were observed in survival in relation to the interval from first symptoms to diagnosis. The survival at 5 years shows some trend towards improvement during the period between 1979 and 1986.

Adult↗
PubMedDate not supplied

Alternating chemotherapy in advanced non-small cell lung cancer: a phase II study.

Fifty-three patients with advanced non-small cell lung cancer (NSCLC) were treated with alternating two-drug schedules cisplatin/vindesine and ifosfamide/mitomycin. Objective response (complete and partial response) was obtained in 31% (confidence limits 18.6-44%) of patients. The median duration of response was 26 weeks. The median survival was 25 weeks, with 24% of patients alive at 1 year. The toxicity was acceptable. The still poor antitumor activity of the chemotherapy schedules used and the lack of non-cross-resistance are factors that could explain the low antitumor activity of alternating chemotherapy.

Adult↗
PubMedDate not supplied

Influence of extracellular calcium on the actions of guanidine at the rat neuromuscular junction.

Guanidine has been shown to potentiate neurotransmission at the skeletal neuromuscular junction. The present study was undertaken to evaluate whether reductions in extracellular calcium affect the action of guanidine on the reversal of neuromuscular blockade induced by dibekacin and d-tubocurarine in the rat phrenic-hemidiaphragm preparation. Guanidine reversed the blocking effect of d-tubocurarine, the maximal effect occurring with 3 mM at 15 min. This reversal effect of guanidine was potentiated when the extracellular calcium concentration was reduced from 2.5 mM to 1 mM and 0.3 mM. Guanidine was also effective in reversing the neuromuscular depression caused by dibekacin. In this case, it was more potent than in the d-tubocurarine-treated preparations. The maximal effect was observed with 3 mM after 15 min of exposure. When the extracellular calcium concentration was reduced from 2.5 mM to 1 mM, a potentiation of guanidine effects was observed. In this situation, the maximal effect of guanidine was observed with only 0.7 mM. However, further reductions of extracellular calcium (0.3 mM) did not show further increases. The present results show that guanidine reverses the blockade induced by dibekacin and d-tubocurarine, being more potent against the former drug. This suggests that guanidine may be useful in relieving the blockade due to a restriction of calcium entry. Its effects were potentiated when the extracellular calcium concentration was lowered to 1 mM and, in d-tubocurarine-treated muscles, to 0.3 mM. Thus, the effects of guanidine are calcium-dependent but only in a certain concentration range.

Animals↗
PubMedDate not supplied

Facilitatory action of adrenergic drugs on muscle twitch evoked by nerve stimulation in the curarized rat phrenic hemidiaphragm.

The facilitatory effects of alpha-adrenergic drugs on neuromuscular transmission has been studied in the curarized rat phrenic-hemidiaphragm. The reversal effect of blocking action of (+)-tubocurarine on indirectly-induced twitch by alpha-adrenergic agents was higher with noradrenaline (EC50 = 6.51 +/- 0.18 microM) compared with adrenaline (EC50 = 11.80 +/- 1.06 microM) or phenylephrine (EC50 = 17.36 +/- 1.02 microM). Methoxamine, clonidine and azepexol showed no effect. The action of noradrenaline was blocked by prazosin (IC50 = 3.96 +/- 0.76 nM) and tolazoline (IC50 = 10.30 +/- 0.5 nM) but not by yohimbine at the concentration range 0.01-0.1 microM. From these results it could be concluded that an alpha 1-adrenergic mechanism might be involved in the facilitatory action of alpha-adrenergic agents at the level of motor nerve terminals.

Animals↗