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Biomedical subjects

A Bach

Publications and source records attributed to A Bach.

At least 163 records · Page 9Linked to original sources
PubMed1988

[TUR syndrome as a late postoperative complication. Case report].

A 81-year-old patient developed a TUR-syndrome gradually one and half an hour after termination of TURP. Surgery was complicated by perforation of the bladder dome at the end of TURP. Due to extravasation of the perioperative irrigating fluid intraperitoneally and intravascular resorption a TUR-syndrome became apparent. Early diagnosis and rapid initiation of appropriate intensive care resulted in a benign postoperative course and the patient attained full recovery.

Aged↗
PubMed1987

Identification of cDNA clones of the mouse neural cell adhesion molecule L1.

Two cDNA clones of the neural cell adhesion molecule L1 (Mr 200,000) were isolated using lambda gt10 and lambda gt11 libraries constructed from postnatal day 8 mouse brain poly(A)+ RNA. Clone K21 was selected and identified using immunoaffinity purified polyclonal antibodies. It was then used to isolate a secondary clone (K21-1), which hybridized with an oligonucleotide probe synthesized by reverse translation of the aminoterminal sequence of the 80 kDa carboxyterminal proteolytic fragment of L1. Blot hybridization analysis indicated that L1 is encoded by a single gene and transcribed by a single 6 kb mRNA which is present only in cells or tissues known to express L1.

Animals↗
PubMed1986

Brain growth in sick newborn infants: a clinical and real-time ultrasound analysis.

This study concerns 152 neonates admitted between June 1981 and December 1983 in a neonatal intensive care unit. It aims to evaluate brain growth and to analyse the influence of intrauterine growth retardation (IUGR), intracranial haemorrhage (ICH) and ventricular dilatation (VD) in pre-term infants. The babies were first analysed at birth. The sample comprised 127 normal infants and 25 IUGR neonates. An ultrasonic index of cerebral growth was devised: the height of the frontal lobes (HFL), measured in a standardised coronal slice of the brain. According to gestational age (GA), HFL and head circumference (HC) gave a similar assessment of brain growth. A regression line of normal intrauterine values of HFL has been produced according to GA and might be added to the other ways of following the intrauterine growth of the brain after 26 weeks. Brain growth was slower in IUGR, when assessed both by HFL and HC. The infants were also assessed during the postnatal period for a mean period of 27.6 days (S.E.M.: 3.5). They were divided into 5 groups: 45 preterm infants without IUGR, ICH or VD; 45 preterm neonates with ICH alone; 12 preterm babies with ICH and VD alone, 10 preterm infants with isolated FGR, and 8 preterm neonates with IUGR and ICH. A calculation of the global anthropometric (body weight, body length, HC and HFL) weekly increment was made for all infants according to their respective group. No statistical difference in any of these parameters between these 5 groups emerged.(ABSTRACT TRUNCATED AT 250 WORDS)

Body Height↗
PubMed1983

Early intramedullary nailing of femoral shaft fractures: a cause of fat embolism syndrome.

Results of our retrospective review of 100 consecutive patients show that early intramedullary nailing can be accomplished in severely injured patients without increasing the risk of fat embolism syndrome. No cases of fat embolism syndrome were seen after immediate (less than 24 hours) intramedullary nailing of femoral shaft fractures. In contrast, five cases of fat embolism syndrome were found in the patients treated in the traditional manner with initial balanced skeletal traction and delayed intramedullary nailing. There was a trend toward more pulmonary complications in the immediate group. This is attributed to the greater severity of injury present in the patients selected for immediate intramedullary nailing (injury severity scores 23.2 in immediate group; 12.4 in delayed group). The incidence of critical hypoxemia in the immediate group was equivalent to that in another group of injured patients who did not have fractures, but who did have similar injury severity scores.

Adult↗
PubMed1983

Intraspinal migration of a rectal foreign body.

This is a description of a rare case of intraspinal foreign body, a clinical thermometer bulb, which after perforating the rectum migrated through the second left sacral foramina and sacral canal up to the epidural space at S1-L5 level. A first attempt to remove it by laparotomy while it was still in the retrorectal space proved unsuccessful. Retrieval was finally achieved by laminectomy.

Child, Preschool↗
PubMed1983

[Effects of diets containing medium-chain and long-chain triacylglycerols in the genetically obese Zucker fa/fa rat. Composition of fatty acids and triacylglycerols of the liver and adipose tissues].

The effects of a hyperlipidic diet containing medium-chain triacylglycerols (MCT) or long-chain triacylglycerols (LCT) and a control diet on the lipid composition of liver and adipose tissue in the Zucker fa/fa and Fa/- rat are compared. The weights of liver and adipose tissues of the rats fed the MCT diet are little different from those of the two other groups, but they are always higher in obese rats than in lean rats. After feeding the MCT diet, the amounts of the constituent octanoic and decanoic acids in liver and adipose tissues are higher in the fa/fa rat than in the Fa/- rat. The rate of lipogenesis in liver and adipose tissues of the obese rat fed the MCT diet remains high.

Adipose Tissue↗
PubMed1983

Effects of medium- and long-chain triacylglycerols on adipose tissue metabolism in the obese Zucker rat.

The influence of a diet including 18 per cent by weight of long-chain (LCT) or medium-chain (MCT) triacylglycerols on adipose tissue development, and on in-vitro adipose tissue triacylglycerol (TG) synthesis from glucose and palmitic acid, was studied using genetically obese, fa/fa, and control, Fa/-, Zucker rats. The adipose tissue mass was greater with the LCT diet than with either the MCT or control diets, but there was no significant difference between the MCT and control diets. TG synthesis from labelled substrates was not modified by the MCT diet when compared with the control, but was decreased by the LCT diet. The results suggested that the use of MCT in treating human obesity would necessitate levels too high to be therapeutically practical.

Adipose Tissue↗
PubMed1982

Fibrin adhesive system (FAS) influence on bone healing rate: a microradiographical evaluation using the bone growth chamber.

A dividable titanium implant containing two canals was inserted into both tibial metaphyses of 5 adult rabbits to test whether the Fibrin Adhesive System (FAS) can accelerate bone regeneration. On one side the implants were pretreated with FAS whereas the implants on the contralateral side were bathed in autologous blood and marrow. After a healing time of 4-5 weeks the assembled implants were removed and then taken apart. The amount of bone which had grown into the canals was quantified by microradiography and microdensitometry. The FAS-treated implants showed a tendency to contain less bone than the medullary cell-treated ones. It is concluded that more evidence should be gathered before recommending FAS treatment to accelerate bone regeneration. It is submitted in addition that the dividable titanium implant, the Bone Growth Chamber, may be useful for quantification of early bone formation under various experimental conditions.

Absorptiometry, Photon↗
PubMed1982

[Carnitine biosynthesis in mammals].

The oxidation of long-chain fatty acids is carnitine-dependent; these fatty acids penetrate the mitochondrion to be oxidized only when they are bound to carnitine in the form of acyl-carnitines. To meet the need for carnitine, animals depend on both exogenous supplies and endogenous synthesis. The aim of the present paper is to review our knowledge of endogenous carnitine synthesis. The precursors of carnitine are lysine and methionine but its true point of origin is trimethyllysine. This molecule is either obtained from the diet or is synthesized in the body from L-lysine (bound to protein) which is methylated 3 consecutive times by an S-adenosyl-methionine. Trimethyllysine is transformed into hydroxy-trimethyllysine, then into trimethylaminobutyraldehyde and finally into trimethylaminobutrate (or gamma-butyrobetaine). The gamma-butyrobetaine is hydroxylated into carnitine. This reaction chain only functions well when three vitamins--ascorbic acid, pyridoxin and niacin--are present. Studies on rat have shown that skeletal muscle, heart, intestines, testis, and especially kidneys, insure the transformation of trimethyllysine into gamma-butyrobetaine but that only the testis, and especially liver, can hydroxylate gamma-butyrobetaine into carnitine. However, in rat the relative importance of the kidneys and liver in total carnitine synthesis has not yet been determined. The situation is the same in man, although it has been proven that human brain and kidneys, as liver, have gamma-butyrobetaine hydroxylase. It is known that the rate of carnitine synthesis depends on three factors--the amount of trimethyllysine available, the rate of gamma-butyrobetaine transfer to tissue(s) hydroxylating it and gamma-butyrobetaine hydroxylase activity. Moreover, it appears that carnitine synthesis is not slowed down by prolonged fasting, that it does not completely cover body needs during the first postnatal days, and that it does not decrease in two patients with systematic carnitine deficiency.

Age Factors↗
PubMed1981

Age-related changes in biological parameters in Zucker rats.

Changes in a number of morphological and biochemical parameters were observed in genetically obese Zucker rats and in lean controls between 3 and 58 weeks of age. By 3 weeks, the genetically obese rats had higher proportional (wt/100 g body wt) and absolute amounts of adipose tissue, hyperlipemia affecting all the lipid fractions, and hyperproteinemia compared to lean controls. Obesity, hepatomegaly, high concentrations of hepatic lipids and hyperinsulinemia did not appear until the fifth week. In obese animals, liver lipid concentration reached a maximum at 17 weeks of age and then declined. During this time, the triacylglycerol concentration in the serum remained stable, whereas the cholesterol and phospholipid concentrations continued to increase. The glycogen concentration in obese animals increased, both absolutely and compared to lean controls, between the 12th and 43rd weeks of age. From weaning, the Zucker rats, compared to lean controls, exhibited characteristics of obesity (accumulation of adipose tissue, hyperlipemia and hyperproteinemia), which persisted to the age of 58 weeks.

Aging↗
PubMed1981

Comparison of pregnancy-associated murine protein-1 and human pregnancy zone protein.

Immunological cross-reaction between human pregnancy zone protein (PZP, SP-3, alpha 2-PAG) and pregnancy-associated murine protein-1 (PAMP-1) was demonstrated by countercurrent line immunoelectrophoresis using antibodies against the proteins raised in hens. The levels of PZP and PAMP-1 were measured during pregnancy and found to be very similar in the first half of pregnancy. Both proteins were found to be heterogeneous and separable according to surface properties. It is suggested that the murine PAMP-1 can be used to study the physiology of human PZP.

Animals↗
PubMed1981

Phenotypic variability in unweaned 3-week-old Zucker rats.

At 3 weeks of age, Zucker rats could not be classified as normal or obese according to body or liver weight. On the other hand, determination of subcutaneous adipose tissue weight per 100 grams of body weight permitted both phenotypes to be distinguished, provided that the growth variations particular to each litter were taken into account. Rats whose future obesity is predictable using this method, have significantly elevated serum levels of triacylglycerols, total cholesterol and phospholipids. However, further analysis of these values indicated that in fact there were two subgroups of both obese and non-obese rats, i.e., those which had elevated serum lipid levels and those which did not.

Adipose Tissue↗