Search PubMed⌕ Search

Biomedical subjects

A Bès

Publications and source records attributed to A Bès.

At least 19 recordsLinked to original sources
PubMed1986

Pharmacological exploration of dopamine hypersensitivity in migraine patients.

Patients with migraine show a hypersensitivity to dopamine or its agonists. One of these, piribedil, was administered as 0.1 mg/kg intravenously over 30 min to subjects with either migraine or other types of headache. This test provoked in migraine patients an increase of the cerebral blood flow and the peripheral signs of dopamine hypersensitivity:- nausea or vomiting and a rapid fall in blood pressure. In contrast, in those subjects with chronic non-migrainous headache, the administration of piribedil had no effect. The piribedil test appears to possess good specificity vis à vis migraine, enabling a differential diagnosis from atypical periodic headache, a condition difficult to consider as migraine or psychogenic headache on clinical grounds alone.

Cerebrovascular Circulation↗
PubMed1985

[Cerebral blood flow and meningeal hemorrhage. An aid to the surgical decision].

One hundred and eleven measurements of cerebral blood flow (C.B.F.) were performed using the Xenon 133 inhalation method in 80 cases of spontaneous subarachnoid hemorrhage of which 59 were due to ruptured aneurysms. This method is non-traumatic, reproducible and dependable. A correlation was found between clinical condition and C.B.F. values, but in a number of cases which cannot be dismissed, very low mean C.B.F. values or ischemic foci were revealed where clinical state gave no indication. A poor correlation appeared between vasospasm seen by angiography and ischemic foci detected by isotopic technique. Patients' age influenced C.B.F. values but not clinical evolution. No correlation was found between C.B.F. values and cisternal blood seen on CT scan. C.B.F. values, measured in the first two weeks of illness, were significantly higher in those patients having favorable outcome, whatever their clinical state at the time of C.B.F. measurement (comas excluded). The figure of 60 ml/100 g/min for mean cortical flow seemed to be a critical level below which the risk of complication was greater. Below this level or in cases or ischemic foci, surgery was delayed. Thus, C.B.F. measurement promises to be a valuable prognostic tool, playing an important role in the therapeutic strategy for this type of patients.

Adult↗
PubMed1984

[Central pontine myelinolysis with regressive development and x-ray computed tomographic interpretation].

A 68 year-old woman presented after rapid correction of a hyponatremia a clinical picture suggestive of central pontine myelinolysis. Clinical disorders regressed but serial CT scans showed the late development of a central pontine low density area which persisted for several months. Such a lack of correlation between clinical and CT scan data has been previously reported. On the present case the demyelination lesions appeared to have resulted principally from the rapid increase of natremia.

Aged↗
PubMed1983

[Recurrent cerebral ischaemic attacks in young subjects. Arteriolar dysplasia or early atheroma?].

The case of a 33-year old woman with recurrent cerebral and peripheral ischaemic attacks is reported and the difficult nosological problem of juvenile ischaemia is discussed. Thromboangiitis obliterans (Buerger's disease) was excluded by morphological studies of finger tips, temporal artery and dermis, which demonstrated arteriolar dysplasia and premature aging of the connective tissue. A diagnosis of "juvenile atheroma" may be considered in view of the dyslipidaemia and increase in skin cholesterol and apoprotein B concentrations observed. A review of the literature, together with the biochemical and histological findings in this patient, suggests that ischaemic attacks, dysplasia of small vessels and serum dyslipidaemia reflected in the dermis are all manifestations of early atheroma.

Adult↗
PubMed1983

Cerebral blood flow studied by Xenon-133 inhalation technique in parkinsonism: loss of hyperfrontal pattern.

Cerebral blood flow (grey matter flow) in parkinsonism requires further investigation. The noninvasive method of 133Xe inhalation permits study of larger numbers of subjects than previously used invasive techniques such as the intracarotid 133Xe injection method. Measurements were made in this laboratory in 30 subjects having Parkinson's disease. Mean hemispheric blood flow (F1) values were 70.4 +/- 9.3 ml/100 g/min, compared to 76.3 for a group of age-matched normal subjects, which is a decrease of -7.8%. The most striking difference was the loss of the "hyperfrontal distribution" in parkinsonism. The prefrontal F1 values were only 1.8% greater than the hemisphere grey matter flow, compared with 8.5% in controls of a similar age group.

Adult↗
PubMed1983

[Value of the piribedil test in diagnosing migraine. Apropos of 150 cases].

Patients with migraine show a hypersensitivity to dopamine or its agonists. One of these, piribedil, was administered as 0,1 mg/kg intravenously over 30 minutes to 150 subjects with either migraine or other types of headache. This test provoked nausea and vomiting in 94 p. cent of patients with migraine, and a rapid fall in blood pressure requiring immediate interruption of the infusion in 69 p. cent. In contrast, in those subjects with chronic non-migrainous headache the administration of piribedil had no effect in 61 p. cent and provoked a fall in blood pressure in only 16 p. cent. The piribedil test appears to possess good specificity vis-à-vis migraine, enabling a differential diagnosis from atypical periodic headache, a condition difficult to consider as migrain or psychogenic headache on clinical grounds alone.

Adult↗
PubMed1983

[Atraumatic measurement of cerebral blood flow in spontaneous meningeal hemorrhage].

Cerebral blood flow (CBF) was measured 74 times in 50 patients with spontaneous meningeal hemorrhage using a method involving the inhalation of Xenon-133. The procedure is non-invasive, reproductible, and provides reliable results. Correlation was found between the clinical state and the CBF, but very low mean values for CBF, and ischemic foci associated with these values, were detected in cases where this could not be predicted from the clinical findings. No correlation existed between vasospasm seen on angiography and the ischemic foci revealed by the isotopic method. The age of patients had an influence on CBF values but not on the clinical course. Mean CBF levels during the first two weeks of the disease were significantly higher in patients in whom the course was uncomplicated, whatever their clinical condition (excluding coma) at the time of CBF measurement. A figure of 60 ml/100 g/min for gray substance blood flow appeared to be a threshold value, below which there was a greater risk of complications. Inversely, the outcome was favorable in all cases with a cortical blood flow superior to 70 ml. These findings suggest that cerebral blood flow measurement provides prognostic information which could be of marked assistance when deciding on appropriate therapy in such cases.

Adult↗
PubMed1978

[Peripheral neuropathy with cryoglobulinemia (author's transl)].

The author describe 2 personal observations of peripheral neuropathy with cryoglobulinemia and the 28 cases previously recorded are reviewed. The characteristics of the usually sensorimotor neuropathy are not specific. Nevertheless, the association with purpura, Raynaud's syndrome and leg ulcers and the inconstant aggravation of the symptoms with cold allow the diagnosis to be suspected on clinical grounds. Cryoglobulin can be recognised by immunoelectrophoresis and classified as type I monoclonal, types II and III mixed and polyclonal. Associated disease should be looked for; lymphocytic proliferation or auto-immune disease. If none is found a diagnosis of essential cryoglobulinemia can be made but with caution as cryoglobulinemia can precede by several years the appearance of associated disease.

Aged↗
PubMed1978

[Pseudo-tumoral softening of the cerebellum].

The author establish an onerall picture of cerebellar infarction with brain stem compression after reviewing 63 cases published in the literature and 4 personal observations. The frequency of this affection can be compared with that of cerebellar hematomas. Diagnosis is based on its predominance in males, the early age at which it appears, its rapid and typical onset, and the delayed signs of brain stem compression. Conventional neuroradiological procedures show an expanded cerebellar volume, and the scanner can specify the ischaemic nature of the lesion. As soon as changes in consciousness occur surgical decompression is necessary, first by external drainage of C.S.F. and later, if necessary, by direct access to the postdrior fossa.

Adult↗