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Biomedical subjects

A B Weingold

Publications and source records attributed to A B Weingold.

At least 19 recordsLinked to original sources
PubMed1992

Obstetric performance in patients with the lupus anticoagulant and/or anticardiolipin antibodies.

Antiphospholipid antibodies, notably the lupus anticoagulant and anticardiolipin antibodies, are associated with recurrent fetal wastage, pregnancy complications, and thromboses. Aggressive medical treatment using aspirin and steroids has been recommended. Fifty-one patients with antiphospholipid antibodies, only four with underlying connective tissue disorders, were followed through 53 pregnancies. Aggressive therapy was used in 33 pregnancies, 90.9% of which resulted in successful obstetric outcomes, a highly statistically significant difference compared with previous pregnancies in the same patients. Most pregnancies among nine patients receiving single-agent therapy (aspirin or steroids alone) and eight patients not treated also had successful outcomes. A 48.6% complication rate was found in association with therapy, particularly gestational diabetes mellitus. There was no statistical correlation between dose or duration of therapy and development of treatment-related complications. Although a subgroup of patients with antiphospholipid antibodies will benefit from aggressive therapy, the high complication rate warrants close observation.

Adrenal Cortex Hormones↗
PubMed1989

Difficulty of fetal monitoring in a fetus with intracardiac tumors.

Fetal intracardiac tumors are rare but, when present, are a common cause of poor or uninterpretable fetal heart tracings due to fetal arrhythmias. The most frequently encountered tumor, the rhabdomyoma, is associated with tuberous sclerosis. We present a case demonstrating this difficulty of fetal monitoring in a fetus with an arrhythmia later found to be due to multicentric intracardiac rhabdomyomas. The appropriate evaluation and management of such fetal heart tracings are discussed.

Adult↗
PubMed1988

Acardiac fetus in a triplet pregnancy.

The acardiac monster represents one of the most severe but rare congenital anomalies. It occurs only in multiple gestations associated with vascular anastomoses between the affected fetus and its co-twin. The prenatal diagnosis of an acardiac fetus must be suspected in any multiple gestation in which cardiac activity cannot be documented sonographically in a growing fetus. We report an acardiac fetus occurring in a spontaneously conceived triplet pregnancy. A review of the literature, including pathogenetic theories and sonographic reports, is discussed.

Abnormalities, Severe Teratoid↗
PubMed1980

Nonstress testing.

Physiologic considerations on regulation of the fetal heart rate are reviewed. The types of fetal heart rate acceleration are classified and illustrated. Data from 509 patients undergoing 1,281 nonstress tests are presented, with emphasis on indications, technique, and interpretation. The nonstress test had a false negative rate lower than that of the contraction stress test. Since the false positive rate is high, a nonreactive test requires further evaluation. Progressive loss of baseline variability and decreasing frequency of accelerations appear to be early signs of fetal compromise.

Female↗
PubMed1975

Oxytocin challenge test.

This study reviews the indications, interpretation, and practical application of the oxytocin challenge test (OCT) in 154 patients undergoing 375 tests. It emphasizes aspects of technique which may make the "challenge" nonphysiologic and the stress, therefore, nonquantifiable. Thirty-four positive or suspicious tests were obtained in 22 patients. These results are correlated with clinical complications of pregnancy; antepartum indices of fetal well-being (estriol, ultrasonic serial cephalometry, and the presence of meconium on amniocentesis); and subsequent intrapartum fetal heart rate response. Unsatisfactory (47 in 23 patients), false-positive, and false-negative tests are reviewed in detail. Since false-positive tests (47.9 per cent) are common whereas false-negative tests are rare (2.8 per cent), we conclude that the negative test is a reliable indication in high-risk pregnancies. Positive tests add to out data on the fetus and alert us to the need for a totally monitored labor.

False Negative Reactions↗
PubMed1975

Obstetric aspects of the Guillan-Barré syndrome.

Two additional cases of Guillain-Barre syndrome complicating pregnancy are reported and the 25 previously published cases reviewed. While fetal prognosis is generally favorable, the occurrence of the disease in late pregnancy is a high-rish maternal condition. Respiratory failure and aspiration pneumonitis may result in premature labor and maternal mortality.

Adult↗
PubMed1975

Intrauterine growth retardation: obstetrical aspects.

We have just begun our study of fetal growth retardation. Prenatal influences upon fetal growth are poorly understood and little studied. One may list multiple etiologies, catalogue numerous physiologic processes, and still not know in any given child what went wrong. The questions far exceed our preliminary answers. How does maternal undernutrition significantly effect the fetal "parasite?" Is the syndrome of intrauterine growth retardation a manifestation of a host versus graft phenomenon, with "runting" in the offspring? Are deficits in cell number and size unalterable? Can these deficits be overcome with good postnatal care? How can we better detect the fetus who is undergoing deprivation in utero? What altered biochemical processes exist? Can we reverse such abnormal influences in utero and prevent their consequences to the fetus? Certainly there are numerous additional areas for investigation and thought.

Amniotic Fluid↗