Search PubMed⌕ Search

Biomedical subjects

A B Scheibel

Publications and source records attributed to A B Scheibel.

101 records · Page 6Linked to original sources
PubMedDate not supplied

Valiant neurons and inexorable aging.

Despite an enormous number of variables, both genetic and epigenetic, most neuronal systems eventually show age-related changes. Although no simple description is possible because of the age, species, locus and state specificities of these alterations, the robust metabolic-synthetic load carried by most neurons is eventually reflected in the regressive changes shown by increasing numbers of them. Nonetheless, their remarkable capacity for selective dendritic and spine growth into the period of advanced old age underlines the biological resiliency built into these post-mitotic elements.

Aging↗
PubMedDate not supplied

On the possible relationship of cortical microvascular pathology to blood brain barrier changes in Alzheimer's disease.

A group of alterations in the structure of cortical microvessels is described in the brain tissue of neuropathologically confirmed patients with Alzheimer's disease. These changes include irregular thickening of the vessel walls, infiltration with amyloid and the serum P component of amyloid, loss of the perivascular neural plexus and the frequent occurrence of pits and lacunae in vessel walls. The possibility that these alterations may be related to blood brain barrier defects is suggested.

Alzheimer Disease↗