Biomedical subjects
Publications and source records attributed to A B Rao.
This investigation suggests that the oxazolidine derivative of propranolol is a prodrug which is hydrolysed stereoselectively to propranolol by hepatic post-mitochondrial supernatant. The (S)-form of the prodrug is more stable in the biological system than its (R)-form.
Lysosomal enzymes are important mediators of acute and chronic inflammatory diseases. The release of lysosomal enzymes into cytoplasm stimulate the inflammatory mediators like oxygen radicals, prostaglandins etc. Enfenamic acid, a fenamate, along with other antiinflammatory drugs, did not stabilize lysosomal membrane isolated from normal and activated phagocytic polymorphonuclear leucocytes of different species.
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This study was undertaken to assess speech discrimination under binaural listening with background noise in hearing-impaired subjects. Subjects (58 sensori-neural, 23 conductive, and 19 mixed) were administered an indigenous version of W-22 PB words under: Condition I--Quiet--chamber noise below 28 dB with speech at 60 dB; and at a constant signal-to-noise (S/N) ratio of +10 dB with background white noise at 70 dB in Condition II and 80 dB in Condition III. The scores were a) 81 +/- 16%, b) 77 +/- 9%, and c) 79 +/- 13%. Mean scores decreased significantly (p less than 0.001) with noise in all groups while the score was more (p less than 0.001) at the higher noise level only in the sensori-neural group. The decrease in scores with advancing hearing impairment was less in noise than in quiet, probably due to binaural and satisfactory S/N ratio. The scores did not fall below 70% unless the handicap was marked. The need for suitable standards of binaural speech discrimination under noise in aircrew assessment is emphasized.
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Fractures of the sella turcica are rare and are often difficult to diagnose radiologically. They can produce a wide variety of complications, including septic, neuroendocrine, neurovascular and neuroophthalmologic problems. The authors describe the case of a 17-year-old boy with diabetes insipidus and diplopia secondary to a type II fracture of the sella turcica. They emphasize the clinical importance of fractures in the sellar region in view of their proximity to vital structures and they discuss possible mechanisms of causation.
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