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Biomedical subjects

A B Murray

Publications and source records attributed to A B Murray.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Intranuclear undulating membranous structures in cells of a human parosteal osteosarcoma.

Large numbers of paracrystalline undulating membranous structures (UMS) were observed in the nuclei of dense cells in a human parosteal osteosarcoma. The electron-dense walls of the structures were 15-20 nm thick, and circular profiles had an outer diameter of 60-70 nm and an inner diameter of 25-30 nm. The UMS-containing cell nuclei displayed a number of other characteristic features, including vermicellar bodies, large numbers of interchromatin granules, and prominent perichromatin granules. The possible significance of these features is discussed.

Adult↗
PubMedDate not supplied

Extraskeletal osteosarcoma with unusual ultrastructural features.

A case of extraskeletal osteosarcoma was observed in the thigh of a 33-year-old male patient. Ultrastructurally the tumor was characterized by the presence of a particular dense type of cell, the nucleus of which showed a characteristic combination of features: large amounts of condensed marginated chromatin, prominent perichromatin granules, vermicellar bodies, and undulating microtubules. The tumor also contained intermediate-type cells with a more typical osteoblastic appearance, and more blastic cells. All three cell types contained varying amounts of dilated rough endoplasmic reticulum with prominent inclusions of crystalline material showing a hexagonal or banded pattern, indicating that the cells represent different stages of maturation rather than genuinely different types of cells. Dense cells showing the same characteristic combination of nuclear features have been described once before in a case of parosteal osteosarcoma. Our results indicate that these cells are a particular form of osteogenic cell. The presence of undulating microtubules and vermicellar bodies suggest a possible association with the presence of virus and/or increased levels of interferon.

Adult↗
PubMedDate not supplied

The ecological interdependence of diet and disease in tribal societies.

Observations among nomads suggest there is a strong ecological interdependence of diet and disease in tribal societies which favors survival of man. This relationship may be disrupted by changes in diet to conform to the highly productive technology of the West. Such changes may result in intensification of indigenous disease and in the transfer of disease characteristics of Western societies. To prevent these consequences, relief feeding and long-term attempts to upgrade nutrition should be carried out with traditional foods wherever possible.

Africa↗