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Biomedical subjects

A B Lee

Publications and source records attributed to A B Lee.

45 records · Page 3Linked to original sources
PubMed1975

Free internal mammary artery graft. An improved surgical technique.

An improved method of free internal mammary artery (IMA)-to-ascending aorta anastomosis for cornoary bypass is described. We interposed a small patch of vein with a suitable side-branch or brancyes in connecting the proximal end of a detached IMA or radial artery. Thirty-four free IMA-to-coronary artery bypasses were performed in 25 patients; 16 right IMA, 14 left IMA, and 4 radial arteries were used. Cornoary angiographic follow-up studies performed in all patients between two weeks and six months after operation proved that all grafts were patent and showing a larger lumen than is usually seen in undetached IMA grafts. Concomitantly marked relief of anginal pain was noted in all patients. Oour experience with this technique is very encouraging. All patients are being followed to evaluate long-term graft patency.

Angina Pectoris↗
PubMedDate not supplied

Cerebral trauma-induced changes in corpus striatal dopamine receptor subtypes.

A device designed specifically for mild to severe concussions was used to produce quantitative experimental blunt brain injury in male Wistar rats. We have examined the effects of varying magnitudes of cerebral trauma on the maximal binding capacity (Bmax) of D1 and D2 dopamine (DA) receptors. The Bmax for each receptor subtype was obtained from Scatchard analyses of [3H]-SCH 23390 and [3H]Spiperone binding to striatal membrane. Anesthetized rats were injured--one, two, or three times--once every 24 h, with either a 68- or 268-g rubber-headed reflex hammer accelerated from a predetermined distance. Uninjured nonanesthetized (NA) and anesthetized (A) rats served as controls. No significant difference in receptor density was observed between NA and A rats for each receptor subtype. Immediately (0 h) following injury from the 68-g hammer weight, the density of D1 receptors decreased (50%), then increased (30%) above control levels by 24 h. The same pattern was observed with the 268-g hammer weight. Analysis of variance (ANOVA) showed that there was no overall effect of number of injuries or treatment on the density of D1 and D2 receptor subtypes. However, there was an interaction of both variables on the D1, but not D2, receptor subtype. Partial ANOVA for receptor densities after rats were injured either one, two, or three times showed that receptor density was altered only after the rats were injured one time. These results suggest that striatal DA D1 receptors are downregulated and then upregulated following isolated injury to the cerebral cortex.

Animals↗