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Biomedical subjects

A B Ferguson

Publications and source records attributed to A B Ferguson.

At least 37 records · Page 2Linked to original sources
PubMed1975

Synovial regeneration and articular cartilage changes after synovectomy in normal and steroid-treated rabbits.

Ltttle is known of the effects of synovectomy on articular cartilage. In order to investigate this matter, anterior synovectomy of the knee was performed in thirty-five normal adult rabbits and in thirty-five which were given 25 milligrams of hydrocortisone intramuscularly each week afterwards. The animals were killed at intervals from four to 110 days after synovectomy. Histological examination of the regenerating synovium in both groups showed complete structural and functional regeneration by eighty days in the first group and a delay in regeneration in the steroid group. Sulphur autoradiographs of the articular cartilage of femoral and tibial condyles revealed surface fibrillation and chondrocyte death in 23 per cent of normal knees after eighty days but only 1.8 per cent of knees of animals receiving hydrocortisone. Thus synovectomy in a healthy joint may have an unfavourable effect on the physiology of cartilage by alteration of synovial composition and hyaluronate content in normal joints. Systemically-administered hydrocortisone may reduce this harmful effect in normal cartilage.

Animals↗
PubMed1971

Orthopedic surgery.

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Femoral Fractures↗
PubMedDate not supplied

Xenotransplantation of neonatal porcine liver cells.

Xenotransplantation of porcine liver cell types may provide a means of overcoming the shortage of suitable donor tissues to treat hepatic diseases characterized by inherited inborn errors of metabolism or protein production. Here we report the successful isolation, culture, and xenotransplantation of liver cells harvested from 7- to 10-day-old piglets. Liver cells were isolated and cultured immediately after harvesting. Cell viability was excellent (>90%) over the duration of the in vitro studies (3 weeks) and the cultured cells continued to significantly proliferate. These cells also retained their normal secretory and metabolic capabilities as determined by continued release of albumin, factor 8, and indocyanin green (ICG) uptake. After 3 weeks in culture, porcine liver cells were loaded into immunoisolatory macro devices (Theracyte devices) and placed into the intraperitoneal cavity of immunocompetant CD1 mice. Eight weeks later, the devices were retrieved and the cells analyzed for posttransplant determinations of survival and function. Post mortem analysis confirmed that the cell-loaded devices were biocompatible, and were well-tolerated without inducing any notable inflammatory reaction in the tissues immediately surrounding the encapsulated cells. Finally, the encapsulated liver cells remained viable and functional as determined by histologic analyses and ICG uptake/release. The successful harvesting, culturing, and xenotransplantation of functional neonatal pig liver cells support the continued development of this approach for treating a range of currently undertreated or intractable hepatic diseases.

Animals↗
PubMedDate not supplied

The pathology of Legg-Perthes disease and its comparison with aseptic necrosis.

A review of pathological material obtained in cases of Legg-Perthes disease and in aseptic necrosis in the adult shows some similarities in distribution of the involved segment of the femoral head. X-ray signs of separation of the central avascular segment from the superior lateral and medial viable segments of the femoral head are recognizable. Crushing in of the weight-bearing segment then occurs and is recognized by flattening of the femoral head outline. At this point the child is in danger of suffering lateral displacement of the viable lateral segment leading to an incongruous extruded femoral head in relation to the acetabulum. Treatment measures must be taken prior to the occurrence of this lateral epiphyseal fracture in order to prevent the development of the stage of the disease where the prognosis is poor.

Adult↗