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Biomedical subjects

A Avni

Publications and source records attributed to A Avni.

50 records · Page 3Linked to original sources
PubMed1981

Antibody pattern to human cytomegalovirus in patients with adenocarcinoma of the colon.

The role of human cytomegalovirus (CMV) was examined according to serological patterns in 37 patients with adenocarcinoma of the colon (ACC). The sera were examined for the presence of IgG antibodies by the immunoperoxidase antibody to membrane antigens (IPAMA) method and by the complement-fixation (CF) test. Antibody determinations were also performed by the IPAMA method for three other members of the herpesvirus group: Epstein-Barr virus (EBV), herpes simplex virus (HSV) and varicella-zoster virus (VZV). Comparison groups included normal subjects, ACC patients treated with chemotherapy, and patients operated on for benign diseases. No significant difference was found in the geometric mean titers (GMTs) for CMV and the other herpesviruses in the sera of nontreated ACC patients when compared with the control groups. However, a significantly elevated antibody titer to CMV was found in chemotherapy-treated ACC patients by both the IPAMA and CF methods. In this group, elevated titers were found by the IPAMA method for EBV and HSV, but not for VZV. The significance of serological studies in elucidating the role of CMV in ACC patients is discussed.

Adenocarcinoma↗
PubMed1981

Syndrome of inappropriate antidiuretic hormone secretion in newborn infants with respiratory problems.

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has not often been described in newborn infants. Of 61 infants with respiratory problems who were admitted to our neonatal intensive care unit over a six-month period from July 1978, three had SIADH, diagnosed on the basis of hyponatremia, weight gain and the excretion of highly concentrated urine. In one infant the onset of marked hyponatremia was very rapid and resulted in deep coma. The occurrence of this syndrome in 5% of infants under intensive care for neonatal respiratory problems makes it essential to monitor these infants closely for deviations in fluid and electrolyte balance.

Female↗
PubMed1980

Ovarian pregnancy and IUD.

Two cases of ovarian pregnancy associated with an IUD in situ are described. One of the cases documents the first reported case of ovarian pregnancy coexisting with a Copper-T device; thus the range of types of IUDs combined with ovarian pregnancy is further extended. The consciousness of the physician of the coexistence, in combination with the wide use of updated diagnostic means, especially estimations of low values of HCG and laparoscopy, should ensure early diagnosis of ectopic pregnancies, including ovarian ones.

Adult↗
PubMed1980

Papillary cystadenofibroma of the endometrium.

Six cases of papillary cystadenofibroma of the endometrium were found in he medical literature. A seventh case of this kind of tumor is now described clinico-pathologically and the literature pertinent to this particular type of tumor reviewed.

Adenofibroma↗
PubMed1980

Thymic hormonal activity on human peripheral blood lymphocytes, in vitro. I. Reciprocal effect on T and B rosette formation.

One hour incubation with the thymic extract TP-1 induced reciprocal effect on B and T rosette formation in lymphocytes of human peripheral blood. The percentage of mouse erythrocyte rosette-forming cells among lymphocytes of chronic lymphatic leukaemia was decreased by TP-1 from 54.5% to 27.1% (P < 0.001). No such effect was observed in healthy adult or cord blood lymphocytes. On the other hand, the percentage of sheep erythrocyte rosette forming cells increased significantly after TP-1 treatment, but only under conditions of active rosette formation and not in the total rosette assay. This increase was highly significant in three conditions with relative deficiency of cell-mediated immunity: newborns (17.1 to 28.3%), cancer patients (24.5 to 31.7%) and patients with lepromatous leprosy (19.8 to 31.8%). Only a small increase was noticed in healthy adults. A similarly prepared spleen extract was not active in either B or T rosette assays.

Adult↗
PubMed1979

TSH synthesis and release in the thyroidectomized rat: b) effect of T3.

The time and dose dependent effects of T3 on the anterior pituitary (AP) TSH release and synthesis were studied in rats 5 days after thyroidectomy (T-5d). T3, in various doses, was injected iv to animals which were kileed at various times later. Plasma and AP TSH were measured. T3 lowered plasma TSH to a minimum within 3 h. An inverse linear relationship was found between T3, up to 634 +/- 134 ng/100 g b.w. (mean +/- SD) and plasma TSH. Higher doses of T3 did not lower plasma TSH any further. At T3 of 634 +/- 134 ng/100 g b.w. the specific AP binder was calculated to be 68% to 90% saturated; thus suggesting a relationship between occupancy by T3 of the AP binder and the regulation of TSH release. The TSH release and synthesis rates were compared after 0.5 micrograms, 1 microgram and 25 micrograms T3. All three doses of T3 suppressed the release as well as the synthesis. The effect of T3 on the synthesis rate, however, lagged behind the effect on the release both in time and magnitude.

Animals↗
PubMedDate not supplied

Brush cytology and biopsy in the diagnosis of colorectal cancer. A comparison.

OBJECTIVE: To determine the usefulness of brush cytology of colorectal lesions as compared to biopsy examination. STUDY DESIGN: One hundred brushing cytologies and biopsies were performed on patients who underwent colonoscopic examination for different symptoms. The cytologic smears were classified into five cytologic diagnostic categories. The histologic diagnoses were adenocarcinoma, adenoma and nonneoplastic lesion. RESULTS: Twenty-six cases were cytologically positive for malignant cells, and all were histologically diagnosed as adenocarcinoma. Nineteen cases were suspicious for malignancy on cytology; histologically, eight of them showed adenocarcinoma. Two other cases proved to be adenocarcinoma in subsequent biopsies. Nine cases were adenomas, with severe dysplasia in five of them. Fourteen cases that were cytologically negative with minimal glandular atypia showed seven adenomas and seven nonneoplastic lesions on biopsy. Forty cases negative for malignant cells showed 19 adenomas and 21 nonspecific changes in the biopsy examination. CONCLUSION: Colonoscopic brushing cytodiagnosis is a sensitive technique for the detection of colorectal cancer. The combination of brushing cytology and biopsy improves the accuracy of diagnosis.

Adenocarcinoma↗
PubMedDate not supplied

Lead poisoning by contaminated flour.

Between October 1982 and June 1983, 43 patients were identified with symptomatic lead poisoning in three Arab villages of the Nablus district. Because of the clustering of clinical poisoning by household units, investigation was focussed on potential sources common to all members of the households. After excluding water, olive oil and a variety of foodstuff, lead in high concentrations was discovered in locally ground flour in all affected households. The source of poisoning was lead poured into the fissures between the metal housing and the driveshaft of the millstone. Significant lead contamination of freshly ground flour was demonstrated in 23% of the 146 community flour mills operating in West Bank villages. Since the completion of these studies, similar outbreaks of lead poisoning caused by contaminated flourmills have been identified in the Upper Galilee and in Spain. As the methods of milling in the Mediterranean area are similar, a coordinated international effort is needed in order to eliminate this health hazard from countries where similar community stone mills are still in use.

Adult↗