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Biomedical subjects

A Attanasio

Publications and source records attributed to A Attanasio.

82 records · Page 5Linked to original sources
PubMed1975

Hormonal profiles in anovulatory patients treated with gonadotropins and synthetic luteinizing hormone releasing hormone.

Ten patients with hypothalamic anovulation weretreated with a "retard" preparation of synthetic luteinizing hormone releasing hormone (LHRH) after an HMG stimulation in order to induce ovulation and pregnancy. Four of the patient ovulated after intramuscular administration of the LHRH preparation. This study suggests that is is possible to induce ovulation with LHRH in patients pretreated with HMG, and that LHRH has advantages over HCG since it does not induce hyperstimulation even in the presence of exagerated follicular growth. Nevertheless, the optimal conditions for the use and monitoring of LHRH treatment have yet to be clarified.

Adult↗
PubMed1975

Plasma estrogen and androgen concentrations in children during adolescence.

Using Sephadex LH-20 chromatography and a radioimmunological technique, the simultaneous measurement of estrone, estradiol, testosterone and dihydrotestosterone was performed in a single extract of peripheral plasma in children. In 44 boys and 43 girls, the mean plasma concentration of estrone rose steadily in both sexes, though more pronounced in the girls. For estradiol, this increment was noted only for the girls. For testosterone, the boys showed a spurt after pubertal stage 3, whereas the girls did not show any rise throughout the developmental phases. The girls, however, showed increment in dihydrotestosterone, concentration from pubertal stage 1 to 3, and plateaued thereafter. The boys showed marked increment in the concentration of this steroid throughout development, although less pronounced as that seen for testosterone. Plasma estrogens correlated better with the clinical evaluation of sexual maturation than with chronological ages in the girls. Similarly, the boys showed better relationship between the androgens and maturational stages than with chronological age. The girls also demonstrated a steep increment in the SDs for the estrogen values with sexual maturation (at stages 3 and 4, the SDs for estrone and estradiol were 0.26 and 0.80 respectively, at stage 5 they were 0.82 and 1.49 respectively) reflecting perhaps the onset of cyclic activity. When the estrogen values were related to the androgen values, the boys demonstrated a high association (r equals 0.78). This correlation was absent in the girls.

Adolescent↗
PubMedDate not supplied

[Surgery of congenital malformations in developing countries: experience in 13 humanitarian missions during 9 years].

The authors report their surgical experience concerning seriously impaired children due to congenital malformations or other non-congenital anomalies such as burns and traumas. All the patients were operated in one of 13 humanitarian missions undertaken in four developing countries. Throughout the "Third World" the demand for reconstructive surgery is extremely high due to the high birth rate and consequently large number of patients, as well as the shortage of both medical staff and supplies. In developing countries Primary Health Care has always been considered a priority and so hospitals, which are used mainly for emergency operations, are usually few in number and badly equipped; elective surgery is considered a luxury. Children with congenital diseases and/or other non-congenital anomalies who are fortunate enough to reach a hospital will often be treated by general surgeons lacking specific training; those children suffering from disabling conditions are often neglected and left to live with their anomalies for the rest of their lives. Our surgical missions have always been undertaken at the request of Catholic missionaries and/or secular organizations which contribute to the individual health schemes of each country. Highly experienced volunteer staff took part in the missions; medical teams are made up of 2 surgeons, one or two anaesthetists and two scrub nurses. The assistance and cooperation of local medical staff was essential in the preselection of cases to be operated while each single medical team provided all the necessary supplies for surgery, which took place in small but well-equipped missionary hospitals provided by the local authorities. A total of 1140 children were operated on during the 13 missions: 32% of these had routine procedures performed in day surgery and 54% underwent major plastic and reconstructive surgery for facial, uro-genital and anorectal malformations or for serious consequences of burns or traumas. The proportion of emergencies was only 3% as these were normally excluded because of the short duration of the missions. 26 patients had to be reoperated as a result of complications or surgical failure and long-term follow-up provided by either the local staff or as a part of later missions was given in over 70% of the major surgery performed. On the whole, the surgical results were highly satisfactory even if a final evaluation should be made taking the cultural factors and the socio-environmental conditions of each individual country into consideration. Such an evaluation should most importantly be made on the basis of the well-being of the patient, general satisfaction of the families involved and improved quality of life of these children.

Adolescent↗
PubMedDate not supplied

Long-term treatment with carbamazepine affects CSF somatostatin immunoreactivity in epileptic patients.

A number of pharmacological evidence supports the view that somatostatin (SS) may be importantly involved in the seizure susceptibility both in humans and in laboratory animals. In a previous report the Authors have provided the finding that a short-term carbamazepine (CBZ) administration is able to reduce SS-CSF-IR in epileptic patients. The present study has been carried out to investigate whether a long-term treatment with CBZ affects in a similar way SS-IR content in CSF from temporal lobe epileptics (CPS). The results confirm and expand previous evidence suggesting that CBZ lowering effect on CSF-SS-IR may be relevant to its anticonvulsivant action.

Carbamazepine↗
PubMedDate not supplied

[Low-dose oral contraceptives and pulmonary embolism: a case report].

We have observed a deep venous thrombosis with pulmonary embolism in a young woman receiving low-dose oral contraceptives; this adverse drug effect was not associated with some risk factor and, in particular, with a demonstrable congenital or acquired clotting abnormality. It is reported that EP can induce deep venous thrombosis with different mechanisms, as hemorheological changes with subsequent poor clearance of locally activated clotting factors, or an increase of platelet or leukocytes aggregation, or a direct effect on some clotting factor; furthermore, it is well known that oral contraceptives may induce antibodies to synthetic hormones, with detection of circulating immune complexes, that might produce thrombosis by damaging the vascular endothelium or interfering with clotting factors or platelet aggregation. Moreover, only a familial history of thrombosis or a past history of recurrent deep venous thrombosis, especially in young age, may justify a broad and highly expensive screening of latent clotting abnormalities, that may significantly increase the risk of vascular thrombosis with the use of oral contraceptives.

Adult↗