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Biomedical subjects

A Asberg

Publications and source records attributed to A Asberg.

51 records · Page 3Linked to original sources
PubMed1997

Additional value of biochemical tests in suspected acute appendicitis.

OBJECTIVE: To evaluate the efficacy of biochemical tests in diagnosing acute appendicitis. DESIGN: Open prospective study. SETTING: District hospital, Norway. SUBJECTS: 257 patients with suspected acute appendicitis. INTERVENTIONS: Initial diagnostic accuracy of a logistic regression model using available clinical data was compared with results of corresponding models that included an increasing number of inflammatory parameters. MAIN OUTCOME MEASURES: The estimated probabilities of appendicitis in different testing groups were analysed using receiver operating characteristic (ROC) curves. RESULTS: A model including only clinical variables had a mean area under the ROC curve of 0.854. When the total white blood cell count, C-reactive protein concentration, and neutrophil count were added, the model improved significantly to 0.920. CONCLUSION: Biochemical tests are of additional value in a computer model, and the tests should, if used rationally, also provide physicians with important information in the investigation of acute appendicitis.

Abdominal Pain↗
PubMed1994

[Troponin T in acute myocardial infarction. Diagnosis and prognosis in patients admitted for suspected acute myocardial infarction].

Cardiac troponin T (TnT) is a new serological marker for use as a diagnostic tool for myocardial damage. A blinded prospective multicentre study representing 298 patients who on admission were suspected of acute myocardial infarction (AMI) to the coronary care units of six Scandinavian hospitals was undertaken to assess the diagnostic performance and prognostic efficacy of a new cardiospecific TnT immunoassay. We used a discriminator value of TnT of 0.20 micrograms/l. One hundred and fifty-five patients (52%) had definite AMI, based on WHO criteria (all had peak S-TnT values > or = 0.20 micrograms/l); 127 patients (43%) had ischaemic heart disease (IHD) without AMI; and 16 patients (5%) had non-IHD (all had peak S-TnT values < 0.20 micrograms/l). The 127 IHD-patients without definite AMI could be subdivided into a group of 44 patients with S-TnT peak values > or = 0.20 micrograms/l, and a group of 83 patients with TnT below this level. A follow-up study was able to define the clinical significance of these findings. The cumulative six months probability of suffering cardiac death or AMI was significantly higher in the subgroup with increased TnT values (14% (6/44)) as compared to the other subgroup (4% (3/83)) (Log-rank test, p = 0.025). The probability of cardiac events was 15% for the patients with definite AMI. We conclude that increased troponin T in serum can detect a subgroup of IHD-patients in whom AMI has been ruled out, but who still have a prognosis as serious as that of patients with definite AMI.

Adult↗
PubMed1994

[Variation in the number of clinical chemical analyses requested by primary health care].

The number of clinical chemical tests requested by the primary health care sector in one year was registered in ten municipalities. Considerable inter-municipality variation was found. Some variation in test requesting could be explained by differences in number of inhabitants per general practitioner. The request for tests increased with decreasing number of inhabitants per general practitioner. No statistically significant correlation was found between number of tests and morbidity in the case of two conditions where the use of tests is well defined. Most of the variation was unexplained, indicating a problem of quality connected to the use of clinical chemical tests.

Chemistry, Clinical↗
PubMed1993

[Diagnostic tests--use and interpretation].

Diagnostic tests are often difficult to interpret. Use of methods intended for binary tests leads to loss of information when these methods are applied to quantitative tests. The author reviews methods for correctly interpreting qualitative and quantitative tests, for finding the best combination of tests, and for assessing when to test.

Decision Making↗
PubMed1993

Diagnostic performance and prognostic value of serum troponin T in suspected acute myocardial infarction.

Cardiac troponin T (TnT) is a new serological marker for use as a diagnostic tool for myocardial damage. A blinded prospective multicentre study representing 298 patients suspected of having acute myocardial infarction (AMI), and admitted to the coronary care units of six Scandinavian Hospitals was undertaken to assess the diagnostic performance and prognostic efficacy of a new cardiospecific TnT immunoassay. We used a discriminator TnT value of 0.20 microgram l-1. One hundred and fifty five patients (52%) had definite AMI, based on WHO criteria (all had peak S-TnT values of > or = 0.20 micrograms l-1); 127 patients (43%) had ischaemic heart disease (IHD) without AMI; and 16 patients (5%) had non-IHD (all had peak S-TnT values of < 0.20 microgram l-1). The 127 IHD-patients without definite AMI could be subdivided into a group of 44 patients with S-TnT peak values of > or = 0.20 microgram l-1, and a group of 83 patients with TnT below this level. An equal identification of these patients among the centres was seen (mean +/- SD 35 +/- 13%; range 20-55%). A follow-up study was able to define the clinical significance of these findings. The cumulative 6 months probability of suffering cardiac death or AMI was significantly higher in the subgroup with increased TnT values (14% (6/44)) as compared to the other subgroup (4% (3/83)) (Log-rank test, p = 0.025). The probability of cardiac events was 15% for the patients with definite AMI.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

Diagnostic efficiency of lactate dehydrogenase isoenzymes in serum after acute myocardial infarction.

Diagnostic efficiency of lactate dehydrogenase isoenzymes were studied in 117 consecutive patients admitted with some symptoms of acute myocardial infarction. The results of lactate dehydrogenase isoenzyme tests were not available to the physicians, who diagnosed the patients according to criteria based on clinical symptoms, electrocardiographic findings and changes in three serum enzymes. Acute myocardial infarction was diagnosed in 41 patients. The diagnostic efficiency of lactate dehydrogenase isoenzyme 1 and the various ratios between this and the other isoenzymes were compared using receiver operating characteristic curves and logistic discriminant analysis. Lactate dehydrogenase isoenzyme 1 was the best parameter on the second day after admission. On that day, calculating the various ratios between isoenzyme 1 and the other isoenzymes did not improve discrimination.

Adult↗
PubMed1987

Analysis of serum concentration of phenobarbital, phenytoin, carbamazepine and carbamazepine 10,11-epoxide by solvent-recycled liquid chromatography.

A rapid and precise low cost method for analysing phenobarbital, phenytoin, carbamazepine and carbamazepine 10,11-epoxide using liquid chromatography is described. Recycling reduced the mobile phase consumption by 75%. Recovery was 97.7-101.4% and between days CV was 1.3-1.7%. The retention times of potentially interfering substances are listed.

Carbamazepine↗
PubMed1984

Evaluation of dipsticks for the assessment of microhaematuria.

Three types of dipstick were evaluated for the detection of microhaematuria. One type showed no false positives with erythrocyte-free urine, and no false negatives with a urine erythrocyte concentration of 20 X 10(6)/l using 5-10 X 10(6)/l as limit. This pattern of readings was produced by all the observers, thus indicating that method variation was satisfactory. The two other types of dipstick were clearly less sensitive, and had less desirable characteristics.

Adult↗