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Biomedical subjects

A Arsenault

Publications and source records attributed to A Arsenault.

At least 37 records · Page 2Linked to original sources
PubMed1988

Intrinsic job stress and diastolic blood pressure among female hospital workers.

The present study of 375 female hospital workers assesses the impact of two specific dimensions of vocational stress on standing diastolic blood pressure. Both intrinsic (pertaining to job content) and extrinsic (associated with job context) stressors were examined in this study. Diastolic blood pressure was found to be significantly related to scores on an intrinsic stress measure, but not with the extrinsic one, even after the contribution of obesity and age levels were controlled. However, the effect of intrinsic stress was only found to be significant among women younger than 35. We believe this to be preliminary evidence that perceived dimensions of chronic intrinsic role stressors can be significant psychosocial correlates of diastolic blood pressure.

Adult↗
PubMed1984

Effects of sino-atrial ischaemia on the heart rate response to phasic burst stimulation of the right cervical vagus in the dog.

The effects of occluding sinus node arteries on the pacemaker responses to graded phasic burst stimulation of the right cervical vagus were studied in anaesthetised dogs. In six dogs (Group I), phase response curves (vagally affected atrial cycle plotted against the phase of the stimulus in the cycle) to 1, 3 and 5 pulse burst stimulations were determined at control and hourly for 3 h after the occlusion. In four dogs, the occlusion produced a slowing of the heart rate, a shift of pacemaker outside sinus node region and a displacement of the phase response curves upward and to the right. Identical stimulation bursts resulted in significantly longer atrial cycles than at control, and bursts introduced with a longer phase remained effective and resulted in significantly longer atrial cycles than the maximum one reached at control. However, when the vagal responses were corrected for occlusion-induced changes in spontaneous PP intervals, the occlusion was found not to significantly affect the vagal responses except to increase their variability. Time-related differences in the effects of the occlusion were not statistically significant. In six control dogs (Group II) submitted to the same protocol, occlusion excepted, the vagal response curves changed very little over the 3 h experiments, thus confirming the stability of the experimental preparation used and of the vagal responses obtained in the absence of ischaemia.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1978

Gastrointestinal microbleeding after aspirin and naproxen.

Gastrointestinal bleeding is the most serious side effect encountered with the anti-inflammatory antirheumatic drugs. Using the 51Cr labeling technique, the comparative quantity of blood loss with aspirin or naproxen has been previously done on normal volunteers. With the present study, 12 rheumatoid arthritic patients were controlled in a double-blind crossover study with the same radioactive technique. There is a difference in favor of naproxen. The difference between the baseline period and naproxen administration was not statistically significant.

Adult↗
PubMed1978

[Communication].

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Periodicals as Topic↗
PubMed1976

The influence of vesical distension on the urethral resistance to flow: a possible role for prostaglandins?

The possible role of prostaglandins in the mediation and/or modulation of the urethral response to vesical distension was investigated in female dogs. Three criteria for the possible involvement of these mediators have been investigated. Indomethacin could block the reduction of urethral resistance observed during vesical distension. Intra-arterial infusion of exogenous prostaglandin E2 resulted in a dose-dependent reduction in the urethral resistance to flow. Moreover, a significant release of prostaglandin E2 in the venous blood during the course of vesical distension could be demonstrated. The functional significance, mechanisms of release and mode of action of these highly active lipids are discussed.

Animals↗
PubMed1976

Gastro-intestinal microbleeding under acetylsalicylic acid, ketoprofen and placebo.

A quantitative comparison of gastro-intestinal microbleeding induced by acetylsalicylic acid (ASA), 3.6 g daily, ketoprofen (KETO), 200 mg daily and placebo (P) was undertaken in 12 normal volunteers using a double-blind factorial design with repeated measures. We conclude that KETO induces less gastro-intestinal bleeding than ASA but more than placebo and that there is a significant residual bleeding under placebo following ASA.

Anti-Inflammatory Agents↗
PubMed1976

Gastrointestinal microbleeding in normal subjects receiving acetylsalicylic acid, placebo, and R-803, a new antiinflammatory agent, in a design balanced for residual effects.

This study was undertaken to compare the relative gastrointestinal toxicity of equipotent doses of acetylsalicylic acid (ASA), 900 MG q.i.d., and a new anti-inflammatory agent, R-803, 300 mg q.i.d., against placebo. Gastrointestinal micro-bleeding was quantitated with the 61Cr-labeled erythrocyte assay. The experimental design was balanced for residual effects in the first week following any treatment. An interesting relationship between stool weight and blood loss was found to influence the microbleeding independently of the treatments themselves. All observed blood loss values were corrected by regression to a reference stool weight of 100 Gm. Final analysis of corrected values was done on arithmetic and logarithmic scales. On both scales, R-803 induced much less blood loss than ASA. A difference of 1.3 ml/day between R-803 and placebo was not statistically significant on the arithmetic scale. On the log scale, a statistically significant difference was found; but since it corresponds to 0.4 ml/day, it was not considered to be clinically significant at this dosage.

Anti-Inflammatory Agents↗
PubMed1976

[Effects of intrathoracic pressure on cerebral circulation in the monkey as a function of body posture, sitting or standing].

Sixty-four measurements of CBF were performed in 8 monkeys in supine and in sitting position under various conditions of ventilation. The position of the body does not normally influence the response of brain circulation to CO2. The response is not different from normal with high insufflation pressure in supine position and the capacities to autoregulation seem to be maintained. In vertical position however there are no longer any significant relations between CBF and PaCO2, and the loss of autoregulation seems to occur earlier and to be more marked. Correlation of these findings to neuroradiologic data indicates that the cerebral venous drainage through the meningospinal plexus is enhanced in vertical position and that during intrathoracic hyperpressure the cerebral venous blood is retained in the jugular vein and meningospinal plexus, thus decreasing the cerebral venous pressure increase and maintaining a perfusion of brain tissue compatible with the survival of the animal.

Animals↗
PubMed1976

Gastrointestinal blood loss induced by ketoprofen, aspirin and placebo (preliminary report).

In a 4-week double-blind multi-crossover trial 12 healthy volunteers received 1-week treatment with aspirin (3.6 g daily) and 1-week treatment with ketoprofen (200 mg daily). Before and after each active drug treatment the volunteers received 1-week of placebo treatment. The gastrointestinal blood loss was quantitatively determined by use of the radioactive chromiun (Cr51) technique. It is concluded that the gastrointestinal blood loss during the ketoprofen treatment was significantly less than during the aspirin period but significantly greater than during the placebo periods.

Adult↗