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Biomedical subjects

A Arrigo

Publications and source records attributed to A Arrigo.

At least 55 records · Page 3Linked to original sources
PubMed1984

Acute i.v. vincamine teprosilate administration: quantified investigation in elderly subjects.

The EEG changes in elderly subjects with chronic cerebrovascular disorders (CCVD) are well known and have been described by many authors. Vincamine teprosilate (Teproside), a drug supposed to act on the electrical activity of the brain, has the properties of modifying and, to some extent, improving age-related changes. Ten subjects, whose age ranged from 60 to 70 years, underwent the trial. Each received 1 ampoule i.v. of the active drug and 1 ampoule of placebo (or vice versa) after a 48-hour wash-out period, according to a double-blind randomized schedule. EEG recordings were performed at time 0 and then 30 min, 1 h, 2 h, and 4 h after injection. A double effect of vincamine teprosilate could be observed at the quantified EEG: 1) an early effect, i.e., an improvement of the EEG pattern within the first hour following administration; and (2) a slow-occurring effect that prevented negative EEG modifications from taking place at the fourth hour following administration.

Aged↗
PubMed1983

Electromyographic investigation in early diagnosis of carbon disulphide neuropathy: a study on 216 workers with different degrees of exposure.

An electromyographic (EMG) investigation was performed on 216 workers of a viscose rayon plant with different degrees of exposure to CS2. In the light of the data supplied by the survey the AA. maintain that meedle EMG is able to detect, probably better than other test, changes of PNS even if they are very slight, and to select subjects having a higher risk of suffering from neuropathies. Nevertheless, also because of its sensitivity, EMG seems to be less specific than other electrophysiological parameters such as maximal motor conductions velocity (MMCV), that is significantly altered in exposed people. Muscular changes may be connected to a specific effect of CS2 less surely than MMCV change. However, they might be considered as pointing to a predisposition to PNS illness and it seems advisable to eclude these subjects from CS2 exposure.

Adult↗
PubMed1981

Chronic treatment with phenytoin in rats: effects of peripheral nervous system.

60 albino Sprague-Dawley female rats, 250 g of body weight, were treated for 6 months with phenytoin 30 mg/100 g/die per os (mean plasma levels: 10-20 gamma/ml). Between 75 and 90 days of treatment motor and sensory nerve conduction velocities were examined along the tail (Miyoshi and Goto, 1973; Fiaschi et al., 1977) in 15 treated animals and in 10 untreated control animals. A slowing of sensory conduction velocity was shown in 6 treated animals (40%); in 2 of them (13%) the motor conduction velocity was also showed. 25 treated rats were controlled with the same neurophysiologic methods after 165-180 days of PHT treatment in comparison with 10 controls; a slowing of sensory conduction velocity was observed in 14 treated rats (56%) and a slowing of motor conduction in 5 of them (20%). The hystological and ultrastructural study carried out on the sciatic nerves of all animals revealed changes of myelinated fibres only in the animals with slowed motor conduction velocity. The non-myelinated fibres were apparently normal.

Animals↗
PubMed1977

Hemifacial spasm associated with dolichomegavertebrobasilar anomaly.

3 patients suffering from long-lasting "cryptogenetic" hemifacial spasm in association with dolichomegavertebrobasilar anomaly, are described. The angiographic examinations confirm the anomaly and put in evidence the patholphysiologic value of segment V4 of the vertebral artery at the same side of the spasm. Classical electromyographic examinations, and methods used to study the blink reflex, seem to rule out the hypothesis of a brain stem involvement as the only and sufficient pathologic mechanism. The peripheral pathogenesis is the most likely one.

Aged↗
PubMed1975

Myasthenic decrement and myasthenic myopathy. A study on the effects of thymectomy.

Motor unit action potentials, M responses to repetitive nerve stimulation, and anticholinesterase tests were investigated in 12 myasthenic patients before and after thymectomy. In six of them the endarterial acetylcholine test was also carried out. Responsiveness to ACTH or to prednisone treatment was evaluated before and after thymectomy. The typical myasthenic presynaptic disorders were improved by thymectomy, while signs of myasthenic myopathy (according to Rowland's definition) were apparently increased. This process of 'functional myopathophanerosis' is discussed and explained in terms of a previous presynaptic disorder blocking the voluntary recruitment threshold of those motor units which are most affected at both presynaptic and postsynaptic level.

Acetylcholine↗