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Biomedical subjects

A Aromaa

Publications and source records attributed to A Aromaa.

160 records · Page 9Linked to original sources
PubMed1976

Breast cancer and use of rauwolfia and other antihypertensive agents in hypertensive patients: a nationwide case-control study in Finland.

Two nationwide registers, the Finnish Cancer Registry and a register of persons entitled to free drugs for hypertension, were linked in a case-control study of the association of breast cancer and use of rauwolfia. Cases were all hypertensive patients in whom breast cancer was diagnosed in 1973. To test the association specifically with rauwolfia, controls were hypertensive women matched with the cases for age and geographic area and approximately matched for duration of treatment for hypertension. There were 109 case-control pairs. Use of any physician-prescribed drugs during the year prior to diagnosis of breast cancer was ascertained from original prescriptions. In the first set of analyses the patients were classified according to the drug used during most days of the year ("main antihypertensive agent"). In the second set a person qualified as a user of the respective drug regardless of the amount taken. The relative risks in the use of rauwolfia, methyldopa, another synthetic antihypertensive or a diuretic as main antihypertensive agent all ranged between 0.90 and 1.11. The results based on use of a drug in any amount were similar. Next, pairs in which duration of treatment for hypertension was different for cases and controls were excluded. The relative risk associated with use of rauwolfia as main antihypertensive agent then increased from 1.00 to 1.30 and the risk associated with use of any amount of rauwolfia from 1.16 to 2.14. Simultaneously, the relative risk in the use of digitalis was raised from 1.33 to 2.67 and of nitroglycerin from 1.00 to 1.71. Cases also used more types of antihypertensive agents simultaneously than controls. There was no association between rauwolfia-use and breast cancer in analyses limited to pairs in which neither case nor control used digitalis. Thus, there was not a consistent drug-specific association between rauwolfia-use and breast cancer in hypertensive patients. An underlying association of hypertension, heart disease or its treatment (digitalis) and breast cancer may have confounded some of the results of this and earlier studies. In conclusion, it is unlikely that use of rauwolfia increases the risk of breast cancer.

Adult↗
PubMedDate not supplied

Serum cholesterol and triglyceride concentrations of Finns and Finnish Lapps. I. Basic data.

Serum cholesterol and triglyceride (TG) concentrations have been studied in six Finnish population groups in South and East Finland and in one group of Finnish Lapps in North Finland. Altogether 11626 Finns, aged 15 or above and 828 Lapps of all ages were studied. Serum cholesterol and TG concentrations of the Lapp children were higher in the age group 0--4 than in the age groups 5-9 and 10-14. Mean serum cholesterol of girls aged 0-9 was higher than that of the boys. The sex and age dependence of mean lipid values in the adults were in several respect similar to those observed in other industrialized populations. The serum cholesterol mean rose with age to reach a maximum in age group 50-59 in men, in age group 60-69 in women. Among the adults, women had lower cholesterol means than men only in age groups 30-39 and 40-49. The serum TG distribution was markedly skewed, and logarithmic transformation brought it closer to normal. Maximal log(TG) values (greater than 12 hours' fast) were attained by men aged 30-39 and by women aged 60-69. Men had considerably higher TG levels than women in middle-aged groups. Of all the sex and age groups studied, the men aged 30-39 had the most skewed cholesterol frequency distribution. Up to this age variability in men's cholesterol values were also increased, as reflected by an increasing S.D. As to women the cholesterol S.D. increased until the age of 60-69. In all the age groups above 14 years, the variability of TG values was larger in men than in women, but it was not age dependent.

Adolescent↗
PubMedDate not supplied

Serum cholesterol and triglyceride concentrations of Finns and Finnish Lapps. II. Interpopulation comparisons and occurrence of hyperlipidemia.

Only small differences in serum cholesterol means and somewhat larger, but still modest differences in log(TG) means were observed, when seven Finnish population groups were compared. Semiurban and industrial groups had the highest triglyceride levels. Cholesterol levels tended to be lower in South Finland than in East or North Finland and lowest in semiurban population groups. Between 15-59 years of age, rural Finns of both sexes had higher and after this age lower cholesterol means than the Finns in the other population groups. The highest cholesterol levels below the age of 60 were observed in a rural population group in East Finland. The Finnish Lapps and the rural Finns had nearly identical serum lipid levels in spite of the differences in genetic background and way of life. The serum lipid concentration means were quite similar to those reported from the other Nordic countries, Denmark, Norway and Sweden. The differences between the populations of the Nordic countries are no larger than those observed between the Finnish population groups. However, no population in Scandinavia or elsewhere can confidently be said to have higher serum lipid levels than the Finns. The similarity of the lipid levels observed in different areas in Finland and in the larger Nordic area is remarkable in view of the large differences in the incidence of coronary heart disease and in mortality rates. It is conceivable that part of the variations in disease rates is attributable to differences in the prevalence of hyperlipidemias, although the present study does not prove this hypothesis. Such differences could occur in spite of similarities in the lipid concentration means. Prevalences of hyperlipidemias in Finland are given.

Adolescent↗
PubMedDate not supplied

Incidence of stroke in a Finnish prospective population study.

The incidence of stroke was investigated in a large Finnish prospective population study. The study population consisted of 11,984 men and 11,682 women aged 15 years and over drawn from four geographical regions of the country. In a mean follow-up time of six years, 174 men and 169 women suffered a fatal or non-fatal stroke. The age-adjusted mean annual incidence of stroke in men, 4.0/1000, was statistically significantly higher than the annual incidence in women, 3.3/1000. In twelve percent of the cases stroke was caused by subarachnoid hemorrhage and in ten percent by cerebral hemorrhage. In 30 percent of the cases, cerebral infarction was ascertained as the cause of the stroke; while in 49 percent of the cases, the type of stroke could not be specified with certainty. The incidence of stroke was significantly higher in non-attendants than in attendants at the initial survey. The incidence of cerebral infarction appeared to be higher in men from eastern Finland than in men from southwestern Finland.

Adolescent↗
PubMedDate not supplied

Prevalence of stroke in Finland.

The prevalence of stroke was investigated in a Finnish population study. The results were based on cross-sectional data from a follow-up examination of a prospective study conducted in 1973-1976. The study population drawn from four regions of the country comprised 11,103 men and 11,096 women aged 20 years and over. The age-adjusted prevalence of stroke was 10.3/1000 in men and 5.8/1000 in women. The prevalence was significantly higher in non-attendants at the examination than in attendants. In 15 per cent of the prevalence cases the stroke was caused by subarachnoid hemorrhage, in six per cent by cerebral hemorrhage and in the remainder by cerebral infarction or the type could not be specified. Over half (57 per cent) of the survivors of stroke had no or only slight disability; eight per cent were totally disabled. Some form of organic heart disease and hypertension was significantly more common in the prevalence cases than in the others.

Adult↗