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Biomedical subjects

A Aromaa

Publications and source records attributed to A Aromaa.

At least 127 records · Page 7Linked to original sources
PubMed1988

Carcinoembryonic antigen levels in sera drawn 1 to 12 years before diagnosis of cervical malignancy.

We determined serum CEA and beta-HCG levels in women who developed cervical carcinoma 1 to 12 years after the serum samples were drawn. Only 32 diagnostic sera CEA and beta-HCG levels were found. However, the serum CEA levels of the carcinoma patients differed significantly from those of their matched controls, who remained cancer free during the following 8 to 12 years after serum withdrawal. The difference in CEA levels between cases and controls did not depend on the lag period between serum withdrawal and cancer diagnosis, the severity of underlying cervical disease, or smoking habits.

Adult↗
PubMed1988

Overweight and anthropometric changes in adulthood: a prospective study of 17,000 Finns.

Changes in weight, body mass index (BMI), and thickness of triceps and subscapular skinfolds were studied in 17,294 adult Finns who, as part of a health survey, were examined twice after an interval of 4 to 7 (average 5.7) years. During the follow-up, the mean weight and BMI rose in men and women below the age of 50 at entry, changed little in men aged 50-70 and in women aged 50-60, and rapidly declined at later ages. Individual weight changes were generally small; about two-thirds of the participants maintained their weight within 5 kg from the initial weight. About 9 per cent of the men and 4 per cent of the women gained 10 kg or more, and 2 per cent of the men and 4 per cent of the women lost 10 kg or more in 5 years. Weight loss was associated with old age and high initial BMI, whereas weight gain was most common in the young, even in those with a high initial BMI. Young overweight subjects need most attention in prevention and treatment programmes for obesity.

Adolescent↗
PubMed1987

Incidence and risk factors of herniated lumbar intervertebral disc or sciatica leading to hospitalization.

Hospital admissions for herniated lumbar intervertebral disc or sciatica were followed up over a period of 11 years in 57,000 men and women who had participated in medical check-ups in various parts of Finland. Information on their hospitalizations after the baseline examination was obtained by record linkage to the National Hospital Discharge Register. To identify factors predicting back diseases, four controls matched individually for sex, age and place of residence were chosen for each of the 592 incidence cases who were free from severe back trouble and aged 20-59 at entry. Low or intermediate social class and blue-collar occupations in services or industry in men and symptoms suggesting psychological distress in women proved significant predictors for hospitalization due to herniated lumbar disc or sciatica. An association with the risk was suggested for smoking or chronic cough in men and parity in women. Marital status or leisure time physical activity were not predictive of herniated lumbar intervertebral disc or sciatica.

Adolescent↗
PubMed1987

Alcohol consumption and sudden coronary death in middle-aged Finnish men.

The association between consumption of alcoholic beverages (spirits, beer and wine) and coronary heart disease (CHD) mortality, especially the incidence of sudden coronary death (SCD), was investigated in a 5-year prospective population study comprising 4,532 men aged 40-64 years. The amount of alcohol used was estimated on the basis of answers to a self-filled structured questionnaire. The incidence of SCD was statistically significantly lower among abstainers than among alcohol consumers. The relative risk of SCD of alcohol consumers in comparison with abstainers was largest in the oldest age group and it became more apparent after a follow-up of a couple of years. Only the consumption of spirits was positively associated with the incidence of SCD. Among non-smokers the incidence of SCD was statistically significantly higher in consumers than in abstainers, a similar but not significant trend was observed among current smokers. The positive association between alcohol consumption and incidence of SCD was detected both in CHD-free men and in men with prior CHD. Consumption of alcoholic beverages, and in particular of spirits, is associated with an increased risk of SCD in Finnish men.

Adult↗
PubMed1987

Lumbar disc syndrome in Finland.

The prevalence of lumbar disc syndrome (herniated disc or typical sciatica) and its consequences in terms of disability, handicap, and need for medical care were studied as part of the Mini-Finland Health Survey. A sample of 8000 persons representative of the Finnish population aged 30 or over was asked to come for examination, and 7217 (90%) participated. A diagnosis of lumbar disc syndrome based on medical history, symptoms, and standardised physical examination was made for 5.1% of the men and for 3.7% of the women. Half of these patients were assessed to be in need of medical care, over 80% of which was considered to be adequately met. One third of all patients with lumbar disc syndrome had been previously hospitalised for that syndrome, and one fifth of the patients had undergone lumbar surgery. At least slight disability was found in almost 60% of the patients, though severe functional limitations were rare. About 6% of the population's work disability was estimated to be attributable to lumbar disc syndrome.

Adult↗
PubMed1987

Type A behaviour pattern in Finland.

The prevalence of coronary prone behaviour, type A, was investigated in a population sample of 1,958 men and 2,224 women aged 30-64 years representative for all people of that age actively employed in Finland. Type A behaviour was assessed by the Jenkins Activity Survey. The mean values of the standardized AB scale were -5.6 in men and -5.8 in women. Type A behaviour was strongly associated with the level of education, occupational group and the socio-economic status achieved. However, it was not related to the conventional cardiovascular risk factors. The prevalence of coronary heart disease was statistically significantly associated with type A behaviour.

Adult↗
PubMed1987

Practice and control of digitalis therapy in Finland.

In order to assess the adequacy of digitalis therapy in Finland we studied its practice and control in 747 patients who were receiving it regularly. The patients were derived from a sample (n = 8000) representative of the adult Finnish population. More than 90% of the patients were receiving digoxin, mostly 125 micrograms or 250 micrograms, once daily. Few patients were taking digitalis as the sole drug prescribed. The mean number of prescribed drugs for each patient (including digitalis) was 4.2 for men and 4.6 for women. 85% of the patients generally visited their "own" doctor. About 90% of the patients had seen a doctor at least once during the previous 12 months. In spite of this, the control of the therapy was generally considered poor, since almost half the patients were uncertain when the next visit to the doctor would be. Inadequately low serum digitalis concentrations, suggesting inadequate or questionable use of the drug, were observed in 30% of the patients. In 15% of the patients the therapy was considered especially questionable. Probably due to variable prescribing habits in general practice, the proportions of patients on poorly controlled, inadequate or questionable digitalis therapy varied remarkably between regions within the country. The results suggest that digitalis therapy in Finland is often inappropriate. We conclude that the practice and control of digitalis therapy need careful reappraisal in this country.

Adult↗
PubMed1986

Overprescription and underprescription of digitalis.

As part of a health examination of a representative sample (n = 8,000) of the adult Finnish population, cardiac state was assessed in the 747 digitalis users and the 6,329 non-users who participated in the survey. Ninety per cent of the digitalis users were in sinus rhythm and 50% were in sinus rhythm and had a normal roentgenographic heart volume. About 20% of those in sinus rhythm had a normal heart volume and a "subtherapeutic" serum digitalis concentration. The age-adjusted prevalence of digitalis therapy in the presence of sinus rhythm was 8% in men and 10% in women. The total number of these patients in Finland was estimated at 246,000 (95% confidence limits 225,000-267,000). Half of the men and two thirds of the women on digitalis received concomitant diuretic therapy. Atrial fibrillation and/or markedly enlarged heart were observed in 1.5% of the men and 0.9% of the women not receiving digitalis. Their total number in the Finnish population was estimated at 23,000 (+/- 7,000). The results suggest that questionable digitalis therapy is very common since several authors have reported successful withdrawal of maintenance digitalis therapy in at least half of the patients in sinus rhythm. On the other hand, underprescription of digitalis seems to be uncommon.

Adult↗
PubMed1986

Thoracic spine compression fractures in Finland.

The incidence and prevalence of thoracic spine compression fractures were studied in an extensive population sample of Finnish men and women. A segment of the population (57,440 persons) aged 15 years or older participated in the baseline health examinations; 17,557 of the 57,440 were reexamined approximately five years later. Compression fractures were identified from 100 X 100 mm thorax photofluorograms. In the whole Finnish population aged 15 years or older, the incidence rate of compression fractures per 100,000 person-years was estimated to be 31.6 in men and 36.8 in women, with a prevalence rate of 0.75% in men and 0.44% in women. In men, the prevalence and incidence increased gradually with age, whereas in women an abrupt rise was found after the age of 65; this reflects differences in patterns of age-related osteoporosis between the sexes.

Adolescent↗
PubMed1985

When does rheumatoid disease start?

Stored serum specimens collected in connection with a community-oriented epidemiologic study were available from 30 subjects who later developed seropositive rheumatoid arthritis. In 9 of these pre-rheumatoid specimens, the Rose-Waaler test result was positive, and in 16, the latex fixation test was positive. Two-thirds of the samples were positive when the interval between taking the blood specimen and onset of the disease was less than 4 years, and one-third were positive when the interval was greater than or equal to 4 years. The occurrence of rheumatoid factor preceded the onset of clinical disease more often in males than in females.

Adult↗
PubMed1985

Four-year incidence of myocardial infarction and sudden coronary death in twelve Finnish population cohorts.

The incidence of myocardial infarction (MI) and sudden coronary death in four years was studied in 6510 men and 5800 women, aged 30-59 years, derived from 12 Finnish population cohorts constituting the invited population to a prospective study. The incidence of all fatal coronary events in four years was 13.0/1 000 in men and 1.8/1 000 in women. The incidence of sudden coronary death was 7.8/1 000 in men and 0.7/1 000 in women. The incidence of non-fatal MI was 22.2/1 000 in men and 7.3/1 000 in women. Coronary mortality was significantly higher in non-participants in the initial survey than in participants. The incidence of MI was highest in men from eastern Finland (North Karelia), intermediate in men from central and western Finland and lowest in men from southwestern Finland. There were no significant regional differences in the incidence of MI in women. The incidence of MI in this study was in good agreement with that recorded in the myocardial community registers.

Adult↗
PubMed1985

Incidence of different manifestations of coronary heart disease in middle-aged Finnish men and women.

The incidence of myocardial infarction and symptoms of coronary heart disease (CHD) were investigated in a prospective Finnish population study. Drawn from four geographical areas in Finland the study population comprised 5 438 men and 4 924 women aged 30-59 at entry. The results are based on a re-examination of the study population after a mean follow-up time of six years. The average annual incidence of coronary death was 3.8/1 000, and that of non-fatal infarction 6.5/1 000 in men and 0.4/1 000 and 2.1/1 000 in women. Ten per cent of all infarctions were silent, revealed only by ECG changes. Cases of new angina pectoris comprised 40% of all the new events in men but 80% in women. This descriptive report serves as the basis for subsequent analyses comprising risk factors for different CHD manifestations.

Adult↗
PubMed1985

Does beta-blockade provoke intermittent claudication?

Intermittent claudication has been claimed to be a side-effect of beta-adrenoceptor blocking drugs. The confounding effect of coronary heart disease has not been controlled in earlier studies. In this case-control study, the cases were selected from a hospital material of patients with verified intermittent claudication and the controls from a nationwide health survey. The pool of potential cases and controls consisted of persons who had been treated with antihypertensives, but did not have coronary heart disease. The controls and cases were matched for age, sex, place of residence and time of examination. Comparison of current or previous use of beta-blocking drugs among our 55 case-control pairs revealed no association between intermittent claudication and beta-blockade. beta-Blockade is not a risk factor for intermittent claudication.

Adrenergic beta-Antagonists↗
PubMed1985

Prevalence of severe dementia in Finland.

A sample of 8,000 subjects to represent the population of Finland aged 30 years and over was used to identify patients with severe dementia; 141 cases were found. The prevalence of all types of severe dementia was 1.8% in the whole study population and 6.7% in the population aged 65 years and over. The prevalence increased with advancing age to 17.3% in the age group 85 years and over. Primary degenerative dementia constituted 50% of all cases; multi-infarct and combined dementia, 39%; and secondary dementia, 11%. Fifty-seven percent of the patients lived in institutions.

Adult↗