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Biomedical subjects

A Arnaud

Publications and source records attributed to A Arnaud.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

[The glucagonoma syndrome. 3 new cases].

We report three new cases of glucagonoma revealed, 6 to 12 months after its onset, by non-specific and misleading skin lesions associated in all 3 cases with diabetes mellitus, severe deterioration of the general condition and hyperglucagonaemia. Non-invasive methods, such as ultrasonography and computerized tomography (CT), are most helpful to locate the pancreatic tumour. Phlebography with tiered venous blood sampling is useful in difficult cases. A false positive result has been recorded with arteriography. Ultrasonography and CT have yielded two false negative results. The alpha-chain of the chorionic gonadotrophin hormone has limited value in the diagnosis of malignant glucagonoma. Treatment is surgical, but despite it, the prognosis is severe (two of our three patients died), due to the risk of thromboembolism, to cachexia and to metastases that are frequent at the time of diagnosis.

Aged↗
PubMedDate not supplied

[Erythropoietin treatment in Piedmont and Valle d'Aosta].

The paper reports a study carried out in the Dialysis Centres of Piedmont and the Aosta Valley on the use of erythropoietin in the treatment of anemia in patients undergoing regular dialysis. The efficacy of the drug and collateral and/or undesirable effects were evaluated. It was found that the drug was efficacious in 99.2% of the 342 patients receiving treatment on 30-6-1990, whereas undesirable effects were observed in 14.6% of cases. Data from the Nephrology and Dialysis Service in Asti are also reported.

Adult↗
PubMedDate not supplied

[Use of calcium carbonate as an intestinal chelator of phosphorus].

Fourteen patients undergoing periodic dialysis who had been taking AL(OH)3 as an intestinal chelant of phosphorus have been examined. AL(OH)3 was replaced by CaCO3 for a period of 6 months. At the end of the study, statistically significant reductions were evidenced in alkaline phosphatase, basal serum aluminiaemia and its increase after Desferal test, while the bicarbonates (HCO3) were found to be increased. Statistically non-significant increases were observed in calcaemia, PTH, and pH. It is concluded that the replacement of AL(OH)3 with CaCO3 is effective in controlling phosphoraemia, in diminishing serum concentrations and tissue deposits of Al and in improving uraemic acidosis.

Adult↗
PubMedDate not supplied

[Effect of hydrocortisone injections on bronchial obstruction in asthma (author's transl)].

In 14 asthmatic subjects with bronchial obstruction reversible by beta-sympathomimetic drug inhalation (salbutamol), the effect of intravenous injections of placebo and of 2, 4 and 8 mg/kg of hemisuccinate hydrocortisone (HSHC) has been measured by determining the forced expiratory volume in one second (FEV1) every two hours for eight hours. In four patients, FEV1 was not significantly altered by HSHC injection. It was improved in the ten other patients. The latency period lasted at least four hours and the peak action was observed between the sixth and the eighth hour. These two factors were related to the HSHC dose. The improvement obtained with 8 mg/kg HSHC was similar to that of salbutamol. The effect of the latter was potentiated by 8 mg/kg HSHC. These results suggest that HSHC should not be used when a fast reaction is wanted, on the one hand, and that the efficacy of the product must be controlled by objective measurements, on the other hand since not every subject is responsive.

Adult↗
PubMedDate not supplied

[Objective immunological and clinical data observed during an altitude cure at Briançon in asthmatic children allergic to house dust and dermatophagoides (author's transl)].

In 42 asthmatic children with positive intradermal skin tests to Dermatophagoides pteronyssinus and domestic dust, assays of total and specific IgE were done at regular intervals during a prolonged (9 months) stay at high altitude (Briançon 1300 m). Geometric mean of total IgE (1047 UI/ml at the beginning) dropped to 40% (p less than 0,001) after the stay. In the same way, specific IgE to dermatophagoides, to domestic dust and to grass pollen dropped during the stay (p less than 0,001). On the other hand, other immunoglobulins (IgG, IgA and IgM) did not undergo any significant variations. Clinical improvement of asthma in these allergic children was observed at the first week of stay and could be maintained without drugs during all the 9 months in altitude. Rather than a consequence of an aspecific effect of altitude on the biosynthesis of reaginic antibodies, it would seem that the very consistent fall in total and specific IgE and the clinical improvement should be interpreted as the result of removal from antigenic provocation into a hypoallergenic atmosphere.

Adolescent↗