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Biomedical subjects

A Ardila

Publications and source records attributed to A Ardila.

At least 19 recordsLinked to original sources

Phonological transformations in conduction aphasia.

Different explanations and subtypes of conduction aphasia are analyzed. Characteristics of literal paraphasias in parietal-insular conduction aphasia are discussed, emphasizing that paraphasias in conduction aphasia are articulatory-based (articulatory literal paraphasias) and due mainly to phoneme substitutions and phoneme deletions; they result basically in switches in phoneme manner and place of articulation. Similarities between errors in ideomotor apraxia and conduction aphasia language deficits are presented. It is proposed that language deviations (in oral as in written language) in conduction aphasia can be understood as a segmentary apraxia of speech.

Aphasia, Wernicke

A comparative analysis of functional status among Spanish- and English-speaking patients with dementia.

The assessment of functional capacity is regarded as an important part of a comprehensive diagnostic work-up for dementia. However, there is a paucity of data regarding comparative functional performance among different ethnic/cultural groups. In this study, we compared Spanish- and English-speaking dementia patients and normal controls on a comprehensive functional assessment battery administered within the clinical setting. Despite equivalent levels of cognitive impairment, Spanish-speaking dementia patients evidenced more difficulties on certain functional tasks relative to their English-speaking counterparts. On the other hand, Spanish- and English-speaking controls did not differ with regards to their functional performance. Results suggest that the extent of deterioration in specific functional subskills may be related to the degree to which they have been overlearned and practiced. Further, they indicate the potential utility of direct functional assessment in both Spanish- and English-speaking populations.

Activities of Daily Living

Luria's approach to neuropsychological assessment.

A. R. Luria's approach to neuropsychological assessment was examined. Three basic points of departure from Luria are presented: his interpretation of cognitive activity as functional systems, his emphasis on the individualized approach, and the importance of the analysis of the errors. A distinction was introduced between Luria's neuropsychological testing, and Luria's neuropsychological approach; the former refers to the specific set of neuropsychological tests Luria used and developed and the latter, to the specific clinical use of these tests. It is emphasized that Luria's basic contribution to assessment in neuropsychology, refers to the clinical approach he proposed and developed. Problems related to the normalization and validity of neuropsychological tests are analyzed. It is concluded that different approaches in neuropsychological assessment are related to the specific goals for which neuropsychological assessment is performed.

Humans

Errors resembling semantic paralexias in Spanish-speaking aphasics.

Forty-one Spanish-speaking left-hemisphere-damaged patients were selected and divided into seven groups (transcortical, Broca's aphasia, conduction aphasia, Wernicke's aphasia, anomic aphasia, alexia without agraphia, and global aphasia). A reading battery composed of eight different subtests was given to each patient (reading of letters, reading of syllables, reading of pseudowords, reading of words, reading of sentences, understanding commands, reading and comprehension of texts, and logographic reading). Different types of reading errors were analyzed. Only in the logographic reading subtest were some word-recognition errors found, resembling semantic paralexias. It is proposed that semantic paralexias in English (and other languages) depend upon the partial logographic nature of the reading system. The importance of cross-linguistic analysis of reading errors, taking into account reading system idiosyncracies, is emphasized.

Adult

Scopolamine intoxication as a model of transient global amnesia.

In Colombia (South America) during recent decades the administration of scopolamine, extracted from plants belonging to the Datura or Brugmansia genus, has become an important neurologic and toxicologic phenomenon. These extracts have been popularly known as "Burundanga." Chemical characteristics and clinical features of scopolamine intoxication are described. Anterograde amnesia and submissive behavior found in patients intoxicated with scopolamine are analyzed. Burundanga intoxication is related to other toxic phenomena found in different countries and similitudes with transient global amnesia are emphasized.

Adult

Neuropsychological deficits in chronic cocaine abusers.

A basic neuropsychological assessment battery was given to thirty-seven chronic freebase cocaine ("crack") abusers. The following tests were used: Wechsler Memory Scale (Wechsler, 1945), Rey-Osterrieth Complex Figure (Osterrieth, 1944) (copy and immediate reproduction), Verbal Fluency (semantic and phonologic), Boston Naming Test (Goodglass, Kaplan, & Weintrab, 1983), Wisconsin Card Sorting Test (Heaton, 1981) and Digit-symbol from the WISC (Wechsler, 1974). In general, performance was lower than expected according to their age and educational level. Subjects showed significant impairment in short-term verbal memory and attention subtests. Neuropsychological test scores were correlated with lifetime amount of cocaine used, suggesting a direct relationship between cocaine abuse and cognitive impairment. A pattern of cognitive decline is proposed.

Adult

Neuropsychological assessment in illiterates. II. Language and praxic abilities.

A basic neuropsychological examination of language and praxic abilities was administered to extreme educational groups (100 illiterates and 100 professionals). Subjects were matched according to sex and age (16-25, 26-35, 36-45, 46-55, and 56-65). The following tasks were included: language comprehension, phonological discrimination, naming (objects, figures, and body parts), repetition of words, verbal fluency, calculation, buccofacial and ideomotor praxis, finger alternating movements, meaningless movements, cancellation task, coordinated movements with both hands, and motor impersistence tasks. All the differences between the two educational groups were statistically significant. Two of the eight language tests (phonological discrimination and naming figures) and three of the seven praxic tests (buccofacial praxis, coordinated movements, and cancellation task) showed differences between age groups with a better performance in the younger groups. Calculation tasks and ideomotor praxis showed differences between sexes with a better performance in males. Influence of educational factors in performing routine neuropsychological tests is analyzed.

Adolescent

Normative data on the Boston Diagnostic Aphasia Examination in a Spanish-speaking population.

Normative data of the Boston Diagnostic Aphasia Examination (Goodglass & Kaplan, 1972) in a Spanish-speaking population is presented. This test was given to 180 neurologically normal adults grouped according to three variables: sex, age, and educational level. The statistically significant differences found are presented. Few differences appeared between sexes, but there were marked differences among the different age groups and in particular among educational levels. A correction to the scoring is proposed for each of the subtests according the patient's educational level.

Adolescent

Is there a cognitive marker in major depression?

The purpose of this study was to compare adolescents' response pattern on specific visual tasks during acute and recovered states of depression. Twenty-three inpatient adolescents with unipolar depression were tested before and four weeks after treatment. Twenty control subjects matched in age, sex, handedness, and intelligence were tested at similar intervals. Measures included four visual spatial tasks: the Gestalt Street Completion Test, the Judgment of Line Orientation, the Hooper Visual Organization Test and the Rey-Osterrieth Complex Figure. Overall, the results indicated that depressed adolescents performed significantly more poorly than controls in all four measures during both pre-and posttest conditions. They demonstrated greatest difficulty in measures of Gestalt Closure and Judgment of Line Orientation. However, the Gestalt Closure task was the only one to be correlated to severity of depression. These findings are discussed in the light of previous research suggesting a right hemisphere dysfunction and the existence of a cognitive marker in affective disorders.

Adolescent

Phonological transformations in Spanish-speaking aphasics.

Thirty-seven aphasic patients whose native language is Spanish were divided into four groups: (1) Broca's, (2) Wernicke's, (3) Conduction, and (4) Anomia. Phonological errors produced on repetition and object-naming tasks were analyzed in terms of type of transformation and degree of similarity between target and errors in terms of shared distinctive features. Segmental transformations were of the following types: (1) pure substitution, (2) pure addition, (3) deletion, (4) reduplicative addition (doublet creation)--anticipatory (right to left) or preservative (left to right), (5) reduplicative substitution (doublet creation)--anticipatory or perseverative, and (6) mutual exchanges. Pure substitutions were the most prevalent, exchanges, the least. Some error types were found to differentiate significantly between aphasic populations. We suggest that different mechanisms may underlie the same error type for different aphasic populations.

Adult

Effects of cultural background and education on handedness.

A 5-item handedness questionnaire was given to 317 subjects in four different groups: (1) 51 Tucano (Amazonian jungle) adolescents (36 male, 15 female); (2) 66 Spanish-speaking adolescents (43 male, 23 female) with similar age and educational background to the Tucano group; (3) 100 urban subjects (50 male, 50 female) with a low educational level; and (4) 100 urban subjects (50 male, 50 female) with a high level of education. Hand preference scores were not affected by sex or educational level. The incidence of left-handedness was lower in the Tucano group than in the other groups, despite the fact that the Tucano culture is a highly permissive one. The two rural groups showed less extreme hand preferences than the urban groups, and the Tucano in particular were less likely to indicate extreme hand preferences on any of the items. These results indicate significant effects of culture and environment on declared hand preference, and may be pertinent to recent discussions of cerebral organization in illiterates.

Adolescent

Calculation deficits in patients with right and left hemisphere damage.

Calculation abilities were studied in 41 left and 21 right hemisphere damaged patients. Their results were compared with a normal group matched by age, sex and educational level. Left hemisphere patients were grouped according to the type of accompanying aphasia. All patient groups presented at least a certain degree of acalculia. However, maximum difficulties were found in retrorolandic left hemisphere patients. Right hemisphere patients, especially retrorolandic patients, also presented impairments in calculation abilities, resulting mainly from spatial defects. Different types of errors were analyzed. Observed errors may be similar, but due to highly different neuropsychological dysfunctioning. Primary and secondary observed defects may be attributed to a diverse array of underlying deficits.

Adolescent

Neuropsychological assessment in illiterates: visuospatial and memory abilities.

A basic neuropsychological battery of visuospatial and memory abilities was administered to extreme educational groups (illiterates and professionals). Subjects were matched according to sex and age. The following visuospatial tasks were included: figure copy (cube, house, and Rey-Osterrieth complex figure), telling time, recognition of superimposed figures, recognition of a map, and drawing of the plan of the room. The following memory tasks were used: basic information, digit retention (forward and backward), memory curve, delayed verbal recall, sentence repetition, logical memory, delayed logical memory, immediate recall of the Rey-Osterrieth complex figure, immediate reproduction of a cube, visuospatial memory, and sequential memory. In visuospatial tasks all differences between the two groups were statistically significant. Five of the seven visuospatial tasks (all but telling time and recognition of superimposed figures) showed differences between age groups with a better performance found in the younger groups and four of the tasks (cube, house, Rey-Osterrith complex figure copying, and telling time) were significant between sexes with a better performance in men. In memory tasks, with the exception of the immediate memory of sentences, all tasks showed statistically significant differences between educational groups. Eight of the 13 memory tasks (digits forward and backward, delayed memory of words, immediate and delayed logical memory, Rey-Osterrieth immediate memory, cube immediate memory, and sequential memory) showed significant differences for age while 4 of the tasks (digits backward, memory curve, Rey-Osterrieth immediate memory, and cube immediate memory) were significant for sex. Results are analyzed with regard to current theories in cognitive psychology and anthropology. Emphasis is placed on the finding that cognitive skills usually examined by neuropsychological tests represent learned and highly trained abilities.

Adolescent

Detection of brain damage: neuropsychological assessment in a Spanish speaking population.

We developed a neuropsychological battery for assessment of cognitive processes that was standardized in 150 neurologically intact subjects from different socioeducational levels in Mexico City (Ostrosky et al., 1985, 1986). The present study was designed to explore the capacity of this neuropsychological battery to discriminate a brain-injured population from a normal one. Thirty-four patients attending the neurological service of two hospitals institutions in Mexico City were studied. The reasons for going to the hospital included both neurological and neuropsychological symptoms. The group was divided into two subgroups: twenty-four patients who showed brain damage confirmed by brain scans, and ten patients with a normal brain scan. A control group of 19 normal subjects was also studied and paired with the other groups by sex, age and sociocultural level. The results show that the neuropsychological battery was able to recognize 83.3% of the patients with scanographically confirmed brain damage: the total percentage of successful diagnosis was 88.2% and there were no false positives. These results indicate that neuropsychological assessment is a powerful diagnostic procedure that also evaluates the patient's cognitive-behavioral activity and can help to predict the possibilities for rehabilitation and return to work.

Adult

Neuropsychologic symptoms in the migraine syndrome.

Twenty patients with complex neuropsychologic symptoms associated with classic migraine were selected from a group of 200 patients with vascular headache. Twenty types of symptoms were found and grouped into six categories (language, visual symptoms, cognitive-dysmnesic symptoms, olfactory-gustatory hallucinations, automatisms, and somatosensory symptoms). Some of the symptoms found have apparently not been reported previously. The importance of the analysis of this complex neuropsychologic set of symptoms and of the possible consequences of complicated, frequent vascular headache is emphasized.

Adult

Complex partial status and schizophrenia.

Three cases of complex partial status which were diagnosed as psychotic episodes are presented. The scans of two of these cases show structural abnormalities in the left temporal lobe. It is proposed that there are similar neurophysiological mechanisms in primary schizophrenia and in the perceptual, affective and cognitive phenomena apparent is some complex and psychic partial seizures. The hippocampal-amygdaline system plays a central role in both cases.

Adult

Severe dementia associated with neurocysticercosis.

A severe case of dementia associated with a parenchymous miliar neurocysticercosis in a 15-year-old girl is described. Although there was general cerebral involvement, EEG, neurological and neuropsychological examinations showed a marked decrease in right hemisphere activity. Treatment with Praziquantel reduced the patient's intellectual deterioration, but hydrocephalus developed.

Adolescent

Temporal lobe involvement in Capgras syndrome.

A Capgras syndrome case is presented. The clinical profile appeared at the onset of treatment with Praziquantel for neurocysticerosis. A left-temporal cysticercum was shown by means of a CT scan. Delusion, accompanied by some neurological symptoms diminished but did not disappear after treatment. The hypotheses for Capgras syndrome are reviewed and it is concluded that it constitutes a cognitive-dysmnesic phenomenon (feeling of unreality, impossibility to integrate recently acquired information with old memory traces) and, as such, its origin is likely temporal.

Adult