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Biomedical subjects

A Aranda

Publications and source records attributed to A Aranda.

116 records · Page 7Linked to original sources
PubMedDate not supplied

Congenital dysfibrinogenemias. A review.

Inherited qualitative abnormalities of fibrinogen have been documented in 144 families. These dysfibrinogenemias have been inherited as autosomal dominant traits and usually are clinically silent, but in some cases are associated with bleeding, thrombosis, or defective wound healing. Dysfibrinogenemias may be associated with defects in any of the three basic steps in the thrombin-fibrinogen reaction, i.e., cleavage of the fibrinopeptides by thrombin, polymerization, and fibrin cross-linking. Biochemical studies of several abnormal fibrinogens have demonstrated that the functional defects are the result of single amino acid substitutions. Most of the reported cases may be distinguished by functional criteria and by the physicochemical behavior and biochemical nature of the abnormal protein.

Afibrinogenemia↗
PubMedDate not supplied

[The usefulness of transesophageal echocardiography in the diagnosis of intracardiac and extracardiac tumors].

We studied 18 patients with suspected intrathoracic mass from january 1990 to august 1993. In all patients electrocardiogram, X-ray, transthoracic and transesophageal echocardiography were performed. Accordingly, the patients were divided into two groups: I) 8 patients with intracardiac myxoma, and II) 10 patients with no myxomatous tumor. The histopathologic identification of the intracardiac or extracardiac tumor was corroborated in all patients of group I and in only 8 patients of group II. In group I the mean age was 39 years and the female sex was more frequently (75%); with transthoracic and transesophageal approaches the myxoma was found in right atrium in four patients, in left atrium in three, and in the last patient the four chambers were occupied. In group II the mean age was 36 years, and the male sex was predominant (60%). In three patients cardiac tumors were detected by echocardiography, two of them were found in the right cavities (leiomyoma and leiomyosarcoma), in the rest the histologic lineage of the left atrial tumors was not possible to recognize. In the other seven patients with mediastinal tumor the heart was not infiltrated. On the basis of the obtained results we conclude that transthoracic echocardiography permits the identification of the intracardiac tumor; in these patients transesophageal studies give us an additional valuable information about the valves, the site of tumoral implantation and the wall infiltration. Transesophageal approach provides more information about its potential cardiac compression.

Adolescent↗
PubMedDate not supplied

[Truncus arteriosus communis and interrupted aortic arch].

The association between persistent truncus arteriosus and interrupted aortic arch is a rare but important condition since it has special clinical and therapeutic implications. In this article we present three cases with this malformation. The clinical characteristics are similar to patients with isolated truncus such as heart failure and cyanosis since birth, a protosystolic click, an ejection murmur over the left parasternal line, heart enlargement, increased pulmonary vascular markings and biventricular hypertrophy. The clinical suspicion of interrupted aortic arch is bases on the presence of asymmetric pulses in the upper and lower limbs, but this difference is present only when the arterial duct is restrictive. Because of that, the echocardiographic analysis, mainly, and the angiocardiogram, secondarily, are very important diagnostic tools. We analyze the echocardiographic diagnostic findings, as well as the angiocardiographic anatomy. Also, some important pathophysiological aspects are discussed.

Aorta, Thoracic↗
PubMedDate not supplied

[Calcified embolism of the coronary artery due to the degeneration of a bioprosthesis in the aortic position].

We present a case of arterial coronary embolism by calcified material of a bioprosthesis of bovine pericardium of the INC in aortic position 8 years after its implantation. Echocardiogram and catheterization with coronarography demonstrated prosthetic aortic dysfunction and normal coronaries. The patient complained of stable angor and dyspnea. During coronarography there was an increase of symptoms together with ECG changes and after a few hours with enzymatic increase. The patient was brought urgently to surgery where mitroaortic prosthesis was changed with mechanic prosthesis. As surgical findings: absence of a leaflet of prosthesis in aortic position with free fragmented calcium in periannular region and two remaining leaflet completely calcified, prosthesis in mitral position of normal appearance. We conclude that ischemia or myocardial infarction in presence of normal coronaries in patients with bovine pericardial bioprosthesis in aortic position can be secondary to calcium embolism, originated by mineralization process of a degenerated bioprosthesis several years after its implantation.

Aortic Valve↗