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Biomedical subjects

A Arai

Publications and source records attributed to A Arai.

103 records · Page 6Linked to original sources
PubMed1986

The first isolation of enantiomeric and meso-zeaxanthin in nature.

Racemic mixtures of (3RS, 3'RS)-zeaxanthin were separated into the three optical isomers, (3R, 3'R)-zeaxanthin (1), (3R,3'S;meso)-zeaxanthin (2) and (3S,3'S)-zeaxanthin (3), by converting to their corresponding dibenzoates and by using HPLC on an optical resolution column Sumipax OA-2000. According to this procedure, it has been shown that only (1) is isolated from higher plants, shellfish, starfish, sea squirt, sea cucumber and then examined; on the other hand (1), (2) and (3) are isolated from zeaxanthin fraction of shrimp, fish and turtle examined. This is the first isolation of enantiomeric and meso-zeaxanthin in nature.

Animals↗
PubMed1985

On the contractile response of fundus strip from rats to matrine, an alkaloidal component of Sophora flavescens.

The administration of matrine, which has antiulcerogenic activity against stress ulcer, exhibited clear contraction on the preparation of the fundus strip of rats at high concentration (from 2 X 10(-4) g/ml). The contractile response of the fundus strip to matrine was not inhibited by treatment with tetrodotoxin, and was not modified with atropine at 10(-4) g/ml, while pretreatment of the fundus strip with antihistamines abolished or reduced the contractile response. The maximum contractile response of the fundus strip was not altered significantly by pretreatment of the rat with indomethacin.

Alkaloids↗
PubMedDate not supplied

Acute renal failure owing to inadvertent vancomycin overdose. Vancomycin removal by continuous arteriovenous hemofiltration.

Acute renal failure developed in a patient who received 56 grams of vancomycin intravenously over a 10 day period. The resulting serum vancomycin level was 284 micrograms per ml and declined to 140 micrograms per ml in a linear fashion with the institution of continuous arteriovenous hemofiltration (CAVH). Our conclusion is that high blood vancomycin levels may be nephrotoxic and CAVH may be an effective means of vancomycin removal in patients with acute renal failure.

Acute Kidney Injury↗