Search PubMed⌕ Search

Biomedical subjects

A Andrion

Publications and source records attributed to A Andrion.

At least 55 records · Page 3Linked to original sources
PubMed1983

Optical determination of coated and uncoated mineral fibers in lungs of subjects without professional exposure.

Coated and uncoated mineral fibers, more than 10 micron long, were counted by light microscopy in digested lung samples from 82 adult subjects without professional exposure. Up to about 150 coated and 12,500 uncoated fibers/g dry weight were found, without any correlation to sex, occupation and smoking habit. An association between counts of more than 1,000 fibers and ages over 50 was observed. The ratio of uncoated to coated fibers was very inconstant. Only the counts of both coated and uncoated fibers seem advisable for an optical evaluation of the possibly pathological mineral fiber burden in the lungs of unexposed persons.

Adolescent↗
PubMed1982

Lung asbestos bodies and pulmonary cancer in subjects without occupational exposure.

Lung asbestos bodies were searched for in 65 subjects with pulmonary cancer and without occupational exposure and in 65 matched controls. No significant association between the presence of asbestos bodies and occurrence of lung cancer was found. Nevertheless, adenocarcinoma was significantly associated with the presence of lung asbestos bodies in men. The latter result suggest that, even in non-professionally exposed subjects, the possibility of relationships between asbestos exposure and lung cancer cannot be excluded.

Adenocarcinoma↗
PubMed1982

Pleural plaques at autopsy in Turin: a study on 1,019 adult subjects.

Hyaline pleural plaques were searched for in 1,019 consecutive autopsies performed on adults in Turin. These pleural lesions were found in 173/706 males and 22/313 females (P less than 0.001). The difference between the sexes was not significant under the age of 50 years but was highly significant (P less than 0.001) in the age groups above 50 years. The severity of the pleural lesions has been graded according to the total area of the plaques. The most severe pleural abnormalities can be considered as connected with previous occupational exposure to asbestos.

Adolescent↗
PubMed1981

[Active tuberculosis unsuspected until autopsy].

A series of 3195 necropsies performed in cases of natural death at the "S. Giovanni" Hospital in Turin, and covering the years 1969-1978, was studied for the prevalence of active tuberculosis. Active tuberculosis was found in 61 cases (1,9%); in 60 a complete clinical history was available. Forty-two out of these 60 cases (70%) were diagnosed only at autopsy, with higher frequency in the old patients. In the 42 patients with undiagnosed active tuberculosis, the acid fast bacilli resulted to have been searched for only in 3 cases, and a chest-film was recorded in 23 cases; in 27 cases of this group, the period between the admission and the death was longer than 8 days (mean 29 days). The clinical diagnosis of active tuberculosis displays intrinsic difficulties; however it must be stressed that an higher proportion of cases could be recognized if one keeps in mind the possibility of this polymorphic disease, so that adequate clinical, laboratory and x-ray investigations should carried out.

Adult↗
PubMed1980

Pleural plaques and lung asbestos bodies in the general population: an autoptical and clinical-radiological survey.

Of 218 necropsies of male subjects, pleural hyaline plaques were detected in 67 (30%). The prevalence of pleural plaques was found to be related to age at death and to history of previous occupational contact with asbestos. The presence of asbestos bodies in lungs was also associated with pleural plaques; however, the reliability of the presence of ferruginous bodies as an indicator of exposure to asbestos is questioned. The role of environmental exposure will be better demonstrated at the end of an investigation on place of residence, which is still in progress. Chest X-rays showed little sensitivity for use in epidemiological surveys.

Age Factors↗
PubMedDate not supplied

Lung asbestos bodies and pleural plaques at autopsy.

Examination for lung asbestos bodies and pleural plaques was made in 996 consecutive unselected autopsies in Torino. The prevalence of asbestos bodies was 12.4% and that of pleural plaques 19.1%. Both findings were found with significantly greater frequency in men, and in the age group above 50 years. In addition, their occurrence increased with age up to 70 years, then decreased thereafter. A significant association between the severity of plaque lesions and the presence of asbestos bodies was found, whereas the number of asbestos bodies was not related to the presence of pleural plaques. It is suggested that pleural plaques are more reliable markers of asbestos exposure started many years earlier, and that lung asbestos bodies are more reliable indicators of more recent exposure.

Age Factors↗
PubMedDate not supplied

Screening of autopsy populations for previous occupational exposure to asbestos.

A screening procedure to select, in autopsy populations, subjects having a major likelihood of previous occupational exposure to asbestos is described. To test our necropsy population we searched for pleural plaques (PPs); the optical count of both lung asbestos bodies (ABs) and uncoated mineral fibers (UMFs) at least 10 microns in length was recorded. In the adult autopsy population studied in the Turin area, the predictive value given by a positive test for large-size PPs (mostly bilateral) was about 55%. This level of probability did not rise in relation to the AB counts, whereas an increase to over 75% was observed if more than 10,000 UMFs/g dry lung were present. In subjects without PPs or with small-size plaque lesions (mostly unilateral), predictive values of positive tests were 20 to 30% when ABs and UMFs were found to be below 100 and 10,000/g, respectively, and increased to approximately 40% if the AB count exceeded 500/g and to almost 70% for an UMF count above 100,000/g. In subjects without PPs or with small-size plaque lesions, the probability of being nonexposed was greater than 90% if neither ABs nor UMFs were found. This autopsy screening may be a reliable tool in selecting cases most probably related to occupational exposure.

Adolescent↗
PubMedDate not supplied

Villoglandular papillary adenocarcinoma of the uterine cervix: report of a case.

Villoglandular papillary adenocarcinoma is a recently described form of adenocarcinoma of the uterine cervix, which apparently affects young women and seems to have a favorable course with an excellent prognosis. We report on a case of villoglandular papillary adenocarcinoma in a 26-year-old woman. The patient was treated by conization alone and is disease free after a 40-month follow-up.

Adenocarcinoma, Papillary↗
PubMedDate not supplied

[Tumor grading in urinary cytology. A study of the cytohistological relationship with evaluation of the kappa statistic for concordance].

In order to verify both usefulness and reliability of cytologic grading evaluated on urinary sediment, we designed a study to test the ability to distinguish consistently between different degrees of neoplastic abnormalities of urothelial cells from voided urine, in relation to the histologic findings of bladder biopsies performed after cytologic reading. Kappa measures were calculated in 112 cytohistologic pairs representative of first disease detection (A) and in 35 pairs representative of disease recurrence (B). Cytology was able to correctly identify a cancer in 70.5% and 80.0% of group A and group B lesions, respectively. Unweighted kappa values of both groups A and B were poor (0.298 and 0.324 respectively). When we considered the weighted kappa, values suggesting fair agreement were obtained (0.576 and 0.500). Our data confirm that urinary cytology shows a good sensitivity in detecting bladder cancer, but it does not seem to give reliable results for the assessment of the tumor grading.

Biopsy↗
PubMedDate not supplied

[The postoperative survival in pulmonary carcinomas depending on the histological type and stage].

The prognostic significance of age, sex, location of the tumor in the various lobes, size, histological type, node metastases, local extent and stage has been studied in a series of 742 surgically resected lung carcinomas. The histological type was a very important prognostic factor: the highest survival was observed in epidermoid carcinomas, followed by adenocarcinomas, anaplastic large cell carcinomas, and anaplastic small cell carcinomas. The stage, as well, except for the adenocarcinoma, bore heavily on the prognosis; however, in small stage I tumours, the postoperative survival was independent from the histological type. The presence of lymph node metastases resulted in an extremely poor survival, except for the epidermoid carcinoma. The size of the tumours, excluding adenocarcinomas, was an important prognostic factor provided lymph node metastases were absent. No significant differences in survival according to the location in different lobes could be ascertained.

Adenocarcinoma↗