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Biomedical subjects

A Andreoli

Publications and source records attributed to A Andreoli.

At least 145 records · Page 8Linked to original sources
PubMed1984

Late seizures in patients with internal carotid and middle cerebral artery occlusive disease following ischaemic events.

The occurrence of post-infarction epilepsy was investigated in 68 patients with angiographically proven internal carotid artery occlusion and in 56 patients with middle cerebral artery occlusion. Epileptic seizures occurred during follow-up in 9% of the carotid artery group and in 21.4% of the middle cerebral artery group. The different incidence of seizures in the two groups was statistically significant. The physiopathological mechanism of the late post-infarction epilepsy is discussed.

Adult↗
PubMed1984

[Cardiac arrhythmias associated with subarachnoid hemorrhage. Prospective study with dynamic electrocardiography].

Electrocardiographic abnormalities associated with intracranial diseases, especially subarachnoid hemorrhage, are well known, while there is hardly mention of cardiac arrhythmias in the neurological and cardiological literature. In order to assess the incidence of arrhythmias 52 consecutive patients with subarachnoid hemorrhage secondary to ruptured aneurysm were investigated with 24-hour Holter recordings. Bradyarrhythmias and tachyarrhythmias were found in 46 patients (88%); premature ventricular beats in 25 pts (12 of these in 3rd-5th Lown classes), ventricular tachycardia in 2, premature supraventricular beats in 14, paroxysmal atrial fibrillation in 1, sinoatrial blocks and arrests in 18, atrioventricular dissociation in 2 and idioventricular rythm in 2. Moreover in 5 pts ST segment changes were found, suggestive of transitory acute myocardial ischemia. The presence and severity of arrhythmias were correlated with the time elapsed from the episode of bleeding, with the QT interval, and with the hemorrhage extent. Our results indicate an high incidence of arrhythmias in subarachnoid hemorrhage, sometimes serious mainly in early stage. Continuous electrocardiographic monitoring is therefore extremely useful and provides data for therapeutic consideration.

Adult↗
PubMed1984

[The schizophrenic patient and his body: remarks on the psychosomatic economy of dissociative psychoses].

For schizophrenic patients, memory and desire are not bodily experiences. Mnemonic traces can be mobilized only at the cost of acute psychotic disintegration of the Self. This paper emphasizes the importance of understanding the Ego structure, the narcissistic economy and psychotic defenses (denial, splitting) as a psychosomatic the organization. Indeed, during somatic illness we observe a reintegration of the body as the hinge between emotional and symbolic aspects of subjective experience. The author suggests that the psychosomatic viewpoint is particularly useful in understanding the clinical evolution of schizophrenia, in psychotherapeutic management of transference and in the elaboration of psychiatric care policies for such patients.

Body Image↗
PubMed1984

A combination of cefuroxime and N-acetyl-cysteine for the treatment of maxillary sinusitis in children with respiratory allergy.

Twenty-four atopic children with allergic rhinitis, asthma and maxillary sinusitis were treated with a combination of cefuroxime 50-80 mg/kg/day and N-acetyl-cysteine 15-25 mg/kg/day administered intramuscularly for 10 days. The efficacy of the treatment was judged on the basis of radiological and clinical evolution. The treatment was effective in 95.8% of the children, and 37.5% of them were able to reduce their treatment for asthma. None of the patients suffered severe side effects. The data obtained confirm that appropriate treatment of the sinusitis frequently results in a significant improvement of the asthmatic condition.

Acetylcysteine↗
PubMed1984

[Choice of symptoms in neuroses. Psychosomatic syndromes].

We think that we have collected a certain amount of arguments in support of the following hypothesis: Without assuming if it is in itself the cause of neuroses, the way of being and of thinking in this world, characteristic of our times' positivistic technico-industrial culture seems to promote a more or less artificial and unconscious anti-anxiety behaviour leading to the psychosomatic syndromes. This way of being in the world and of thinking it is symptomatic of a discrepancy between the exogen (primacy of assimilation) and the endogen (primacy of accommodation) assimilation/accommodation balance. The non-decoupling of the exogen and endogen accommodation leads to a rigid content of concepts and limits the mind process to consider only the materially possible, leading to a regressive causality. Its' ultimate term is the object in which the essence includes the existence, the "causa sui" that is none other than the patient's body. Inability to take into account what is structurally possible makes it difficult to approach the notions of chance and of great numbers, proceeding on to apprehend the time in a way akin to Aristoteles', where the future is reduced to chance. This type of thinking limits the world's understanding to what is materially possible. Outside this, just everything is possible, including the possible the occult sciences account for.

Acculturation↗
PubMed1982

The clinical course and prognosis of carotid artery occlusion.

The clinical course of 100 consecutive patients with angiographically proven carotid occlusion was reviewed. Ninety-three patients had been hospitalised for early stroke appropriate to the occlusion, and seven for transient ischaemic attacks. 68 patients were followed up from 1.5 to 5.9 years. The observed five year survival rate on an actuarial basis was 62.3%, compared to the expected rate of 90% in a matched normal population. The observed rate of recurrent stroke was 4.8% at 1 year. 12.2% at 3 years, 17.1% at 5 years. Among survivors, six patients (11.3%) developed seizures.

Adolescent↗
PubMed1980

Effects of propylthiouracil and methylmercaptoimidazole on thyroglobulin synthesis.

The effect of 6-propyl-2-thiouracil (PTU), and 1-methyl-2-mercaptoimidazole (MMI) on thyroglobulin (Tg) biosynthesis has been studied in vivo and in vitro. In vivo experiments were performed in rats treated for 20 days with PTU or MMI, analyzing soluble and particulate, cold and 125I-labelled, Tg. Thyroglobulin biosynthesis was also investigated by in vitro experiments, incubating thyroid tissue with labelled amino acid and carbohydrate in the presence of antithyroid compounds. It has been found that in vivo antithyroid agents decrease the amount of soluble Tg and increase the proportion of particulate Tg. Tg from treated animals is poorly iodinated being mainly represented by its 12S subunit. In vitro studies demonstrate that PTU and MMI inhibit Tg biosynthesis which is impaired in the polypeptide synthesis as well as in carbohydrate chains addition. Thus the inhibition of the hormonogenetic processes induced by antithyroid treatment leading to a depressed iodinating activity also appears to be related to a significant impairment of the production of the Tg molecule, the specific iodine acceptor.

Amino Acids↗
PubMed1979

Parathyroid hormone and calcitonin levels in vitamin D deficient rickets.

In six infants aged between 5 and 8 months with vitamin D deficient rickets, we have studied blood levels of calcium (Ca), phosphorus (P), alkaline phosphatase, immunoreactive parathyroid hormone (PTH) and calcitonin (CT), as well as urinary excretion of Ca, P, hydroxyproline and cyclic AMP, both under basal conditions and during a 4h infusion of 20 mg/kg 10% Ca gluconate in normal saline. Under basal conditions all the infants had high alkaline phosphatase (range: 470--770 U.I./1); PTH (range: 620--1200 pg Eq/ml) and CT (range: 440--750 pg/ml) but two infants had hypocalcaemia and four had normocalcaemia and hypophosphataemia. The urinary Ca excretion was low whereas the urinary P, hydroxyproline and cyclic AMP excretions were high. During Ca infusion the total serum Ca and CT levels increased, while alkaline phosphatase and PTH fell. After the end of the infusion, CT levels fell perceptibly; phosphaturia, hydroxyprolinuria and cyclic AMP decreased on the day of the infusion.

Alkaline Phosphatase↗
PubMed1976

[Affective-cognitive structure and psychosis. New perspectives of the study of hallucination experience with psychodysleptics].

This paper comparates classic experimental "model psychosis" psychodysleptic induced and psychotic adverse reactions to psychodysleptic habitude or episodic use as clinically observed. Biochemical, neurophisiological and psychopathological back-ground of psychodysleptic states and clinical data are discussed in the aiming to investigate and explain interaction between cognitif and affectif destructuration in spreading off a psychotic crises. A multidisciplinary approach provides new insight about destructuration processes in exogenous or endogenous psychoses and about mental developmental in child.

Affect↗
PubMed1975

[The application of relaxation in hospital geriatrics].

On a three years base experience in the geriatric department of Geneva's university psychiatric clinic, the paper studies among practical problems encountered in the application in institutional geriatry of relaxation, those related to therapists' training and to the nature of therapy control established for them and their patients. Problems pertaining to the management of the cure according to the method of J. de Ajuriaguerra amd M. Cahen are viewed, and the position of relaxation in the post-graduate psychiatric training defined. The study also mentions the influence of relaxation applied to the aged patient on his human environment in and out of the hospital. These notes are complementary to those already presented on the indications of relaxation in geriatry, the way body is preceived by the aged patient through relaxation, and it's consequences on the adjustment of an aging person.

Aged↗
PubMed1975

[Indications for relaxation in geriatrics].

On a three years base experience in the geriatiic department of Geneva's University Psychiatric Clinic the paper studies the problem of selecting aged patients to be treated by relaxation according to the method of J. De Ajuriaguerra et M. Cahen. Observations are presented in an attempt to define three main points: a) the role played by relaxation when there is an objective [corrected] impairment of the body's integrity; b) relaxation effect on aged persons neurotic states evolution; c) the reality of considering dementia as a counter-indication of relaxation therapy. These remarks complete those presented previously about the training of therapists in relaxation, the type of control to be organized for them and their patients, the technical management of the cure, the place of relaxation in the post graduate psychiatric training, the effects of the therapy on the patients human environnement behavior in and out of the hospital, the way body is perceived through relaxation by the aged patients and it's consequences on the adjustment of an aging person.

Aged↗
PubMedDate not supplied

Surgery for chronic pancreatitis: what quality of life ahead?

We attempted to evaluate the quality of life of patients with proved long-lasting chronic pancreatitis. We measured the clinical and psychological status of 60 patients who had undergone various surgical treatments for their disease. The presence and severity of depression and other symptoms of distress were assessed, as were disease-specific functional and physical problems. Few patients had serious conditions, such as pain, malnutrition, or psychoneurotic complaints. The relation between depression and the time of onset of symptoms and of surgery appeared doubtful, and no statistically significant correlations were found between severity of emotional disturbance and other functional characteristics. Insulin-dependent diabetes and correlated diseases had the most negative influence on everyday well-being. Postoperative follow-up and the need for recurrent medical control and care did not lead to negative feelings.

Adult↗
PubMedDate not supplied

[Alpha-thalassemias and bipolar disorders: a genetic link?].

After a previous paper discussing the possible association between beta-thalassemias and bipolar disorder, this article considers a possible association between alpha-thalassemia and the bipolar disorder. We report the case of a 36 year old woman with bipolar disorder and alpha-thalassemia. The patient, native of Reunion Island, has a family history of bipolar disorder (both parents, one brother, and a paternal uncle). The severity of the bipolar disorder type I in her family, is illustrated by the suicides of both parents, one brother and the paternal uncle, in intervals of only a few years. After a Medline review (1980-2004) we found only two studies suggesting a possible relationship between bipolar disorders and alpha-thalassemias, but without clinical case report information. Some genetic studies described the existence of possible genetic susceptibility for bipolar disorder on the short arm of chromosome 16, close to the gene involved in certain alpha-thalassemias, on the region 16p13.3. An interesting finding is that the sequencing of 258 kb of the chromosome region 16p13.3 not only allowed the identification of genes involved in the alpha-thalassemia and in the vulnerability to bipolar disorders, but also the identification of genes implicated in tuberous sclerosis, in polycystic kidney disease, in cataract with microophtalmia, and in vulnerability genetic factors for ATR-16 syndrome, asthma, epilepsy, certain forms of autism and mental retardation. Numerous clinical descriptions and some familial studies on linkage suggested a possible relationship between tuberous sclerosis, polycystic kidney disease, cataract with microophtalmia, ATR-16 syndrome, asthma, epilepsy, certain forms of autism, mental retardation and bipolar disorder, given the closeness of these vulnerability genes on the short arm of the chromosome 16. A vulnerability gene of alcohol dependence was also identified on this same chromosome region (16p13.3), by a study concerning 105 families. Taking into account the methodological difficulties due to the clinical and genetic heterogeneity of bipolar disorder, we suggest that linkage techniques should be used to confirm the presence of susceptibility genetic factor for bipolar disorders on chromosome 16. Thus a known genetic disease (alpha-thalassemia) could contribute to confirming the presence on the short arm of chromosome 16 of a susceptibility genetic factor for bipolar disorders. Linkage studies should be performed in families with a strong association for both diseases. Thanks to linkage techniques, one could hope for an improvement in understanding the physiopathology of bipolar disorder, with possible implications at a therapeutic level.

Adult↗
PubMedDate not supplied

[Activation with amitriptyline: electroclinical comments on 120 epileptic patients (author transl's)].

The sleep-inducing and epileptogenic effects of amitripyline (0.5 mg/kg i.m.) were studied in 120 epileptic patients. Sleep occurred in 94 p. 100 of the patients: 92 p. 100 showed stages I and II, 42 p. 100 also showed stages III and IV, but only 12 p. 100 showed REM. Major activation of inter-ictal abnormalities occurred in 41 p. 100 and seizures were provoked in 17 patients (14 p. 100). Neutral results were obtained in 23 p. 100 of cases. The results obtained and the complete absence of drawbacks recommend amitriptyline for use in studying epileptic patients, at least before turning to other pharmacological techniques which are more dangerous and probably less reliable.

Adolescent↗