Monitoring of lithium treatment through determination of lithium concentration.
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Biomedical subjects
Publications and source records attributed to A Amdisen.
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The renal lithium clearance of a manic-depressive woman rose when she became pregnant and fell to the prepregnancy level when she gave birth. The lithium clearances of four healthy women were higher during pregnancy than after delivery. This emphasizes the need for frequent determinations of the serum lithium concentration and appropriate dosage adjustments during pregnancy and delivery.
Children breast-fed by women on lithium treatment ingested lithium with the milk. Their serum lithium concentration was one-third to one-half the concentration in the nursing women's serum. Bottle-feeding should be considered for children of women on lithium treatment.
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Of 330 patients given lithium for recurrent manic-depressive disorder 12 developed goitre after treatment periods of five months to two years. All the patients remained clinically euthyroid. Pressure symptoms necessitated subtotal thyroidectomy in two patients. In 9 out of 10 patients with goitre, and in two out of seven without goitre study with radioactive iodine showed abnormal findings in iodine metabolism. Discontinuance of lithium led to disappearance of goitres, while thyroid metabolism returned to normal. Thyroxine or desiccated thyroid produced shrinkage of the gland in spite of continued lithium medication.
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