Biomedical subjects

A Altintaş

Publications and source records attributed to A Altintaş.

12 recordsLinked to original sources

PubMed2001

Hepatitis B vaccine related-myelitis?

We present four incidental cases that developed partial myelitis following the administration of hepatitis B vaccine in 1998. The first two cases, a 33-year-old man and a 42-year-old woman developed progressive sensory symptoms without motor involvement within 4 weeks following the vaccination. Their magnetic resonance imaging (MRI) disclosed similar lesions consistent with myelitis at their cervical spinal cord. A comparable inflammatory lesion was seen at the T9-T10 levels of the spinal cord in the third case, who was a 40-year-old woman presenting with numbness in her legs and urinary retention following the vaccination. The fourth case who was a 42-year-old woman, presented with sensory symptoms in her left extremities, which developed 3 months after the vaccination. Her MRI showed a hyperintense lesion at C6. She also had two tiny lesions in her cranial MRI. In all cases, there was no history of preceding infections and no clinical evidence suggestive of any other disorders that may cause myelopathy. All patients recovered completely within 3 months with the exception of the third patient who developed new neurological symptoms after 12 months. Similar clinical and imaging presentation of myelitis following hepatitis B vaccination within a 1 year period with no other demonstrable clinical and laboratory evidence for any other disorder raise the probability of a causal link between these two events.

Acute Disease↗

PubMed2001

Central nervous system involvement in gestational trophoblastic neoplasia.

OBJECTIVE: To evaluate characteristics of patients with central nervous system (CNS) lesions of gestational trophoblastic disease and determine prognostic and therapeutic implications applicable to management. METHODS: Nine patients among 56 cases of malignant gestational trophoblastic neoplasia (GTN) were analyzed prospectively in a single institution between the years 1990 and 1997 with at least two years of follow-up. Brain metastases were documented by physical exam and computed tomography scan or magnetic resonance imaging. In terms of therapy, all of the patients received an etoposide, methotraxate, actinomycin, cyclosphamide and vincristine (EMA-CO) regimen for 5 to 9 courses. To prevent unexpected intracranial hemorrhage, all patients received radiation therapy. No intrathecal chemotherapy was given. Remission was defined as three weekly beta-hCG levels below assay sensitivity (<5 mIU/ml). RESULTS: The mean age of the patients at diagnosis was 29.6 years. While two of the patients initially presented with symptoms related to cranial involvement, five were diagnosed during routine investigation for metastasis in malignant GTD and the remaining two developed cerebral metastases during the therapy. Besides central nervous system involvement, six had additional lung, two had hepatic and splenic and one had pelvic metastases. Overall survival was 66.6%. Two patients had a fulminant clinical course and were lost one month after initial diagnosis. CONCLUSION: Early diagnosis via computed tomography of the head and beta-hCG serum testing along with aggressive, multiagent intervention (EMA-CO) have greatly improved patient prognosis of this once highly fatal condition.

Adult↗

PubMed2001

[Tuhfetü'l-Tib, as a pioneer periodical of the medical history].

Tuhfetü'l-Tib is a Turkish medical history periodical published regularly every two weeks in Istanbul since December 27th, 1867. Its collection comprises totally 15 issues, every one of which is consisted of 16 pages with a hard cover, printed at the Maltepe Military Hospital printing press for more than seven months. As far as we know, Tuhfetü'l-Tib's last issue was dated on July 21st, 1868. The aim of its publication was to introduce contemporary medical knowledge by translating articles from the respected academic periodicals in the West. Among the issues wer have studied, twenty chapters were about gynecology, while twenty five ones about the newborn diseases. Tuhfetü'l-Tib is the second Turkish medical review ever printed in Turkey, succeeding Vakayi-i Tibbiye (1849). It is also the first periodical in Turkey, publishing articles on gynecology and pediatrics. Having played an important role in struggle for the Turkish education at the Imperial Medical School, it was issued on the basis of the principles defended by the Ottoman Association of Medicine.

History, 19th Century↗

PubMed2001

[The medical drugs at Divanü Lügat-it Türk].

Divanü Lügat-It Türk is a great encyclopaedical work written by Kaşgarli Mahmud in the 11th century. This masterpiece gives us detailed information on the Turkish culture of the time. This paper is constituted of five parts and covers all medical drugs mentioned in the book. On the first part, information is given about the physicians and pharmacists charged in drug preparation. The medical drugs of the 11th century have been listed alphabetically in the second part. This list comprises 190 medical drugs each of which has been shown by their counterparts in the Divan up to its volumes and pages in the original text.

Encyclopedias as Topic↗

PubMed2000

Gestational trophoblastic disease: the significance of vaginal metastases.

PURPOSE: To evaluate patients with vaginal lesions in gestational trophoblastic disease and determine prognostic and therapeutic implications applicable to management. METHODS: Twelve patients among 75 cases of gestational trophoblastic neoplasia were analyzed retrospectively between 1990 and 1997. Vaginal metastases were documented by physical examination and biopsy. Two patients received MAC III regimen (5 and 7 courses), 4 patients received EMA-CO regimen for 2 to 11 courses, while 6 were administered methotrexate alone. Remission was defined as 3 weekly beta hCG levels below assay sensitivity (<5 mIU/ml). RESULTS: The mean age of the patients was 25.4 years. While 10 of the patients presented initially with hemorrhage and bloody leukorrhea, the remaining 2 were diagnosed during a routine study of hydatidiform mole. The sites of involvement were almost always the anterior distal vaginal wall. Five cases had additional lung and 1 case had lung, liver, spleen and brain metastases. Three of the patients who received methotrexate as monotherapy did not respond to therapy and were switched to EMA-CO. Overall survival was 91.6%. One patient died in the first month of the initial therapy. CONCLUSION: The presence of large vaginal metastases should be classified as a high-risk factor and these patients must be treated by multiple agent chemotherapy.

Adolescent↗

PubMed1998

Uterus didelphys with unilateral imperforate hemivagina and ipsilateral renal agenesis.

Eight patients with a double uterus, unilateral vaginal obstruction, and ipsilateral renal agenesis are described. The most common clinical presentation was that of the onset of pelvic pain and dysmenorrhea, in association with the finding of a pelvic mass. In seven patients, a window was created between two vaginae by transvaginal route. In one patient, the blind vagina with hematocolpos and attending uterus were extirpated by an abdominal approach. The postoperative courses were uncomplicated in all patients. A greater awareness of this syndrome should lead to accurate diagnosis. Excision of the obstructing vaginal septum offers a complete relief of symptoms while preserving reproductive capacity.

Abnormalities, Multiple↗

PubMed1995

[Assignment of students for the Royal School of Medicine on the basis of ethnic minority population in the Ottoman Empire].

Tibhane-i Amire (Royal School of Medicine) was founded in 1827 in order to train Muslim physicians and surgeons equipped with modern medical knowledge ("novel medicine"). Following the Declaration of Tanzimat (Imperial Decree of Reformation) Non-Muslims were permitted to enroll to the School of Medicine just after the decree on January 16, 1841. At the beginning, to room, board and educate students of different religions and sects were not approved. But the Chief Physician and the Dean of the School of Medicine solved the problem by undertaking all the responsibilities. The first year following the afore-mentioned decree, 38 Christian students were enrolled and their number increased to 76 in the next year. In 1847, 29 students from the Jewish community were accepted to the School, for whom all the facilities covering their religious deeds, needs and customs were provided. The same year some Serbian students were accepted and special treatment was requested, since they were kins to the Serbian Prince. Greeks and Walachians were also accepted to the School, as there had not been any political restriction. In 1851 the total student number was 459, among whom there were 14 Non-Muslims. The same year, day students were also admitted as boarders, since it was hard to go to school in winter. In 1857, the Armenian Patriarch was given an audience by the Grand Vizier on an official demand stating that the assignment to them was not in proportion with their population, so it should be increased. This was approved by the Superior Council of Tanzimat. In 1855 the Greek Patriarch demanded officially that this decree should be withdrawn by stating that the Greek population was much larger than the Armenian's. Upon this, the council rearranged the assignment based on a reliable source and determined that it ought to be 30 for Armenians, 46 for Jews and Latin community, 74 for Greeks (including 15 Bulgarians) and totally 150 Non-Muslims. Together with 300 Muslim students, the student number reached up to 450. ...

Ethnicity↗

PubMed1993

[Abolishment of the office of the Ottoman head physician].

The office of the Ottoman head physician which had been an important organisation for 400 years, was abolished by a decree given by Sultan Abdülmecid on 17 April 1850. This article discusses the factors leading to this abolishment. Some researchers say that the foundation of the Council of Health Affairs (Meclisi Umuru Tibbikye) in the Medical school (Mektebi Tibbiye) just before the decree, might be one of the reasons. Here it is concluded that this factor was not responsible for the decree because the duty of presiding management and chairmanship of the council was already assigned to the Head Physician. There was also another council which had been founded ten years before the decree and it was equipped with the same functions. When the point whether the decree was due to the Head Physician Salih Efendi is studies, we see that didn't have any influence on the said decision, although Salih Efendi had been appointed by Sultan Abdülmecid as the Head Physician and as the Minister of the Medical School both of his duties were withdrawn from him. But later he was again appointed as the Head Physician by the same Sultlan. Another reason was said to be the transfer of the Head physician's duties to the Minister of the Medical School (Tibbiye Nezareti). But the Ministry of the Medical School existed since 1827 and according to the Sultan's order its only duty was stated as providing the discipline of the School. Another reason said to be responsible for the abolition of the Head Physician's office was the several attempts to poison Sultan Abdülmecid. But this also is not enough to explain the problem. Another possibility regarding this subject is the possibility of giving personal opportunities to the Doekyard's Supervisor Ziver Efendi, who after the abolition was appointed as the minister of the Medical School. Thus Ziver Efendi was to be promoted to one of the highest ranks of the state and there was to be great increase in his salary, even having studied all the sources available which might contribute to the solution of the question, it is still not enough to solve the problem satisfactorily.

History, 19th Century↗

PubMed1992

Prognostic value of mitotic activity, eosinophilic and inflammatory reaction in stage I cancer of the uterine cervix.

This study includes 110 patients treated surgically for stage I squamous cell carcinoma of the cervix. The prognostic significances of mitotic activity, stromal inflammatory and eosinophilic reactions were studied. The 5-year survival rate varied from 75.0% to 93.3% and pelvic lymph node metastases (PLNM) varied from 23.0% to 31.2% according to degree of these variables. None of these pathological parameters was found to be a significant predictor of pelvic lymph node metastases and 5-year survival.

Adult↗

PubMed1989

[Not Available].

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History of Medicine↗

PubMed1988

[Not Available].

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History of Medicine↗

PubMed1986

[Not Available].

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History, Ancient↗