Biomedical subjects

A Altchek

Publications and source records attributed to A Altchek.

At least 19 recordsLinked to original sources

PubMed2003

Lichen planus and the vulvovaginal-gingival syndrome.

Lichen planus is a dermatologic disease that affects both skin and mucosa. Here we report five cases of lichen planus that presented as the oral component of the vulvovaginal-gingival syndrome. Four of the cases were associated with biopsy-proven oral lichen planus, and all five patients had oral lesions that clinically resembled lichen planus. Three patients were taking medications that are associated with lichenoid drug reactions; four patients were postmenopausal; and all five patients had desquamative vulvovaginitis. Clinicians may see these patients when they show persistent signs and symptoms of oral lichen planus. We report five case histories and review the 127 cases found in the literature to make the practicing clinician aware of this unusual clinical entity. The hepatitis C virus association and drug-induced lichenoid mucositis are topics that are addressed. In addition, clarification of the issues surrounding the premalignant potential of oral lichen planus is provided with evidence, rationale, and data from the literature to support the position that true oral lichen planus has no inherent predisposition to become malignant.

Adult↗

PubMed1997

Pathologic changes in gonadotropin releasing hormone agonist analogue treated uterine leiomyomata.

OBJECTIVE: To define the pathologic changes underlying the mechanism of shrinkage of uterine leiomyomata in patients treated with luprolide acetate. DESIGN: Retrospective study of pathologic changes seen in leiomyomata removed by hysterectomy or myomectomy in treated and untreated patients, matched by age and size of uteri and leiomyomata. PATIENT(S): Gross description and histologic slides of 30 treated and 30 untreated patients. INTERVENTION(S): Histologic examination performed blindly (without knowledge of treatment). Statistical work-up using chi 2 analysis with 1 df. MAIN OUTCOME MEASURE(S): Degree of hyaline and hydropic degeneration, cellularity, nuclear atypia, necrosis, and obliteration of interface. RESULT(S): Confluent nodular hyaline degeneration representing a scarlike retraction, geographic hydropic degeneration necrosis and obliteration of the interface between myoma and myometrium were found in higher proportions in the treated patients; differences in cellularity, nuclear atypia, and edema were not statistically significant. CONCLUSION(S): The decrease in size of the treated leiomyomata occurs as an accelerated postmenopausal shrinkage because of the antiestrogenic effect of the therapy. Obliterated cleavage planes may explain the difficult enucleation of myomatous nodules in some of the treated patients.

Adult↗

PubMed1995

Pediatric and adolescent gynecology.

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Adolescent↗

PubMed1992

Management of fibroids.

This review covers literature published between December 1990 and November 1991. It shows a continuous outpouring of publications on the use of gonadotropin-releasing hormone agonists and operative hysteroscopy as part of the background of alternatives to hysterectomy. The new technologies question traditional management of fibroids, which may vary considerably in different areas. Abdominal myomectomy, which never received adequate recognition as an alternative in the past, is also discussed. The review concludes with a section on abdominal hysterectomy.

Buserelin↗

PubMed1990

Method of growing vaginal mucosal cells on a collagen sponge matrix. Results of preliminary studies.

A method of obtaining and growing vaginal mucosal epithelial cells in culture on plastic and on a collagen sponge was developed. The results indicate that simultaneous culture of skin and vaginal epithelial cells from the same donor showed morphologically similar growth potential in culture on plastic and on a collagen sponge. Vaginal cells grown on a collagen sponge formed elongated clumps of cells similar to those observed for skin epithelial cells. The results suggest that vaginal cells grown in culture on a collagen matrix may be a suitable biomaterial for use in reconstructive surgery on women with the Rokitansky syndrome or in those who have had a malignancy.

Cells, Cultured↗

PubMed1989

Sonography in early pregnancy: the significance of subchorionic hemorrhage.

Among 31 pregnant women with first-trimester bleeding, all were found on sonographic study to have subchorionic hemorrhage with a living fetus. Twenty-six went on to normal term pregnancies. Two had premature labor at 31 and 32 weeks. Three had first-trimester missed abortions. No correlation was found between volume of subchorionic bleeding and prognosis. The prognosis of the pregnancy in this group of 31 women with first-trimester bleeding and sonographic evidence of subchorionic hemorrhage and fetal cardiac activity was 80% favorable.

Chorion↗

PubMed1987

Preperitoneal herniorrhaphy: adjunct to cesarean section.

A case of inguinal hernia repair at the time of repeat cesarean section is described. The success of the repair and the patient's uneventful recovery suggest that these procedures can be combined conveniently and safely in select cases.

Adult↗

PubMed1986

Late-onset 21-hydroxylase deficiency and polycystic ovary disease. A case report.

In a case of late-onset 21-hydroxylase deficiency (21HD), the clinical presentation was that of polycystic ovary disease (PCOD). Wedge resection of the ovaries yielded tissue that, on histology, was consistent with PCOD. Most likely the PCOD was secondary to the late-onset 21HD.

Adrenal Hyperplasia, Congenital↗

PubMed1984

Common problems in pediatric gynecology.

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Bacterial Infections↗

PubMed1984

Pediatric vulvovaginitis.

Childhood gynecologic problems are different from adult problems in physiology, disease, psychology, evaluation and management. The most common is vulvovaginitis. The child is susceptible to vulvovaginitis because of a relatively exposed vulva, a thin vaginal wall and poor hygiene. Additional problems are heat and moisture, clothing, coverings and possible sexual abuse. Most vulvovaginitis is primary, nonspecific vulvitis with secondary vaginitis. It is set off by poor hygiene and responds to keeping the vulva clean, cool and dry. Persistent or recurrent vulvovaginitis may be due to a variety of causes, including vulvar skin disease, a foreign body in the vagina, primary vaginitis, ectopic ureter and rhabdomyosarcoma. Vaginoscopy is indicated for recurrent vulvovaginitis or bleeding and for suspicion of a foreign body, neoplasm or congenital anomaly. The extent of evaluation depends on the anxiety of the child versus the extent of the problem, and therefore individualization is required.

Bacterial Infections↗

PubMed1981

Vulvovaginitis, vulvar skin disease, and pelvic inflammatory disease.

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Bacterial Infections↗

PubMed1977

Dysfunctional uterine bleeding in adolescence.

Dysfunctional uterine bleeding is one of the most frequent urgent gynecologic problems of the adolescent. Its diagnosis is by exclusion. Dysfunctional bleeding is managed expectantly with the anticipation of ovulation, individualization of therapy and continuous observation. In severe cases, hormal hemostasis and 3 months of cyclic therapy are indicated. In a small percentage of patients dysfunctional bleeding may persist and be associated with serious chronic disturbances.

Adolescent↗

PubMed1976