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Biomedical subjects

A Alomar

Publications and source records attributed to A Alomar.

At least 19 recordsLinked to original sources
PubMed1992

Local and systemic tolerance of flutrimazole skin creams following single and repeated topical application in healthy volunteers.

A double-blind, randomized phase I study was performed in 21 healthy volunteers to evaluate the dermal tolerance of skin creams containing 1% and 2% 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) or only the excipient, versus a commercial skin cream containing 1% clotrimazole. The study was carried out using the patch-test procedure performed in three stages: 1. single application in the back skin; 2. induction period (usage test) using three skin areas on the volar side of the forearm of each subject, where skin cream samples were applied once a day for a period of three weeks; and 3. after a wash-out period of two weeks, challenge applications in the back and forearm skin. The systemic tolerance of the formulations was also tested. There was no evidence of allergic sensitization after the application of flutrimazole creams, or their excipients, with signs of mild and doubtful skin reactions being observed in few subjects with all formulations. Furthermore, no systemic side effects after topical administration were detected throughout the study.

Administration, Topical↗
PubMed1992

Pyoderma gangrenosum in association with erythema elevatum diutinum: report of two cases.

We report on the appearance of centrifugally spreading ulcers with undermined borders in two patients with chronic recurrent erythema elevatum diutinum controlled with dapsone. The ulcerated lesions were consistent on clinical and pathologic examination with the diagnosis of pyoderma gangrenosum. They eventually responded to treatment with oral corticosteroids. The addition of cyclosporine was required in one case. No associated disease was found in any of the patients. The possible pathophysiological mechanisms of this uncommon association are reviewed.

Adrenal Cortex Hormones↗
PubMed1990

[Subcutaneous nodules and sensitivity to aluminum in patients undergoing hyposensitivity immunotherapy].

Hypersensitivity reactions to aluminium are very rate. Sensitization has been reported to occur during continuous application of aluminium-containing antiperspirants or by aluminium adjuvants in vaccines and hyposensitization immunotherapy. We report 5 patients who developed persistent and itching subcutaneous nodules following immunotherapy. Histologically, the nodules showed a granulomatous reaction consistent with delayed hypersensitivity to aluminium. Patch tests with 2% aluminium chloride in water were positive in three patients, and positive results of patch test with other metals (nickel, cobalt) were frequently associated.

Adult↗
PubMed1989

Erythroderma due to ribostamycin.

A 48-year-old man became erythrodermatous after intramuscular administration of ribostamycin, an aminoglycoside antibiotic in the same family as neomycin. Patch tests were positive to ribostamycin and neomycin, as well as to mercurials. There was no mercurial preservative in the injection solution. A lymphocyte transformation test was positive for ribostamycin and tobramycin, but not for gentamycin. Diagnostic and structure-activity relationship aspects of the case are discussed.

Anti-Bacterial Agents↗
PubMed1988

Childhood self-healing histiocytosis X.

A 6-month-old boy had histiocytosis X limited to the skin and oral mucosa, which regressed spontaneously over a period of six months. We review the subsets of autoinvolutive histiocytosis X with special emphasis on the dermatologic manifestations. Childhood self-healing histiocytosis X is a benign condition that should be differentiated from self-healing reticulohistiocytosis (Hashimoto-Pritzker type).

Age Factors↗
PubMed1988

Erythema gyratum atrophicans transiens neonatale: a variant of cutaneous neonatal lupus erythematosus.

We cared for a patient with neonatal lupus erythematosus with cutaneous and hepatic involvement that was clinically and histologically indistinguishable from erythema gyratum atrophicans transiens neonatale, an entity described by Gianotti and Ermacora in 1975, which we consider to be a subtype of cutaneous neonatal lupus erythematosus. The differential diagnosis of any annular erythema in the newborn requires careful clinicopathologic evaluation, with direct immunofluorescence studies and determination of anti-Ro/SS-A, anti-La/SS-B, and anti-nRNP antibodies in both the baby and the mother.

Age Factors↗
PubMed1988

Porokeratotic eccrine ostial and dermal duct nevus.

We report 2 cases of congenital porokeratotic eccrine nevus in a 5-year-old girl and a 7-year-old boy. The clinical manifestations were those of nevus comedonicus palmaris. The histologic picture consisted of comedo-like dilatations and cornoid lamellae involving the eccrine ostia and ducts. One of the cases showed anomalies in the dermal eccrine ducts. We believe that these lesions are eccrine hamartomas unrelated to porokeratosis. We review similar cases from the literature and discuss the differential diagnosis.

Biopsy↗
PubMed1988

[Actinic reticuloid. Immunohistochemical study].

A patient that fulfilled the clinical and histological features of actinic reticuloid has been studied. He presented a positive patch test for fragance mix. Typical cutaneous lesions were reproduced with a solar simulator. The immunochemical studies of the inflammatory infiltrates of these induced lesions gave a higher percentage of T8 in relationship to T4 lymphocytes. Most of the cells were HLA-DR positive. No clonality of these lymphocytes was detected. In the peripheral blood lymphocytes, an increased percentage of T8 lymphocytes was also observed.

Exudates and Transudates↗
PubMed1988

Familial leiomyomatosis cutis et uteri (Reed's syndrome).

We report a large family with leiomyomatosis cutis et uteri. Sixty-four percent of the females were involved; 18% had only uterine myomas, 10% had only cutaneous piloleiomyomas, and 36% had both. Five patients (45%) had to have an hysterectomy before age 35. Management of female patients having leiomyomatosis cutis should include a periodical gynecological examination in order to rule out the presence of uterine myomas.

Adult↗
PubMed1987

[Ito's hypomelanosis].

Three additional cases of hypomelanosis of Ito (HI) are reported. HI is a syndrome manifested by irregular macular hypopigmented lesions, resembling the negative image of incontinentia pigmenti. Their cutaneous manifestations, associated abnormalities and the peculiar characteristics of the reported cases are discussed.

Adolescent↗
PubMed1986

Localized intestinal perforation after intravenous indomethacin in a premature infant.

A female premature infant born after 27-week gestation developed a localized perforation of the terminal ileum six days after the administration of intravenous indomethacin for PDA closure. This complication has been reported after enteral and rectal administration of the drug. However, our clinical finding supports that these lesions in premature infants are not only related to the local effects of enteral indomethacin.

Female↗