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Biomedical subjects

A Albertazzi

Publications and source records attributed to A Albertazzi.

At least 91 records · Page 5Linked to original sources

Checkerboard reversal pattern and flash VEPs in dialysed and non-dialysed subjects.

In forty-three patients suffering from chronic renal failure (CRF; 32 non-dialysed, 11 dialysed) the flash VEP and the pattern VEP to different spatial (7.5', 15', 30', 60' checks) and temporal (2, 10, 20, 40 Hz) frequencies were investigated. Abnormally delayed flash VEPs were obtained in 53.6% of the cases; transient pattern VEPs had a delayed major positive deflection in 46% of the tested eyes and altered steady-state response in 58% with a total of 65% abnormal responses. Chronically dialysed subjects showed higher levels of altered VEPs for both the techniques. The shorter latencies normally observed with coarser checks in healthy people were maintained in CRF patients, resulting in an abnormal prolongation of the shift between high and low spatial frequencies. Higher statistical correlations linked the pattern VEP with blood urea nitrogen (P less than 0.001) and other renal chemistry than the flash VEP. These and other features could be ascribed to a specific involvement of a maculo-calcarine channel devoted to 'detailed' vision and suggest the usefulness of this method to provide a tool for the early detection of an encephalopathic uraemia.

Adult↗

Neurophysiological abnormalities in uraemic encephalopathy.

Sophisticated electrophysiological assessments have been employed to display cortical alterations in uraemia and to follow the influence of haemodialysis treatment (RDT). Flash-Visual Evoked Responses (VERs); Pattern Reversal Visual Evoked Potentials (VEPs); Brain-stem Auditory Evoked Responses (BAERs); Electroencephalogram (EEG) with Berg's analysis of frequencies were recorded in 15 uraemic patients, 10 of whom subsequently started RDT. VER latency was delayed compared with controls and unmodified after RDT. VEP latency was similarly delayed returning to normal range with RDT. BAER, preliminarily recorded only in 10 patients, showed increased latency of waves I, III, V. EEG showed 7 to 10 and 10 to 13 Hz to be reduced, and after eight months of haemodialysis the 13 to 20 Hz band increased.

Adult↗

[Preliminary experience in extracorporeal renal surgery and autotransplants].

Successful management of stenosis of a polar branch of the renal artery by means of autotransplantation is reported. The main indications for this technique are described: arteriosclerosis and injury to the artery, aneurysm, various forms of ureteral injury, bilateral or unilateral renal tumour, coralliform intraparenchymal lithiasis, together, with the techniques for extracorporeal perfusion of the kidney and the mechanisms of the more commonly adopted conservation solutions.

Aneurysm↗

Residual renal function and effective rehabilitation in chronic dialysis.

The results of a 1-7 years follow-up of multiple processed and recorded semiquantitative parameters in 148 cases of chronic uremia on regular dialysis treatment (RDT) are reported. Patients were grouped according to different levels of residual creatinine clearance (CCr) at the beginning of treatment (0-5, 5-15, and 15-21 ml/min). Regardless of a possible return to work and reasonable quality of life, patients on RDT with 0-5 ml/min CCr invariably present a worsening in various subclinical parameters semiquantitatively evaluated (bone biopsies; nerve conduction velocity; glucose A-V, etc.). In patients with 5-15 ml/min CCr better results are found. In patients with residual CCr above 15 ml/min, impairment in several parameters is hardly evident and even after several years of dialysis may still remain minimal. These results seem of importance as far as the effective and not the apparent dialysis rehabilitation is concerned.

Adolescent↗

Survival and 'true' rehabilitation after dialysis and transplantation: a 7-year follow-up.

Serial follow-ups of processed and recorded semi-quantitative data (bone biopsies, nerve conduction velocity, glucose A-V, etc.) have been carried out in 152 chronic uraemic patients of which 39 underwent kidney transplantation. The comparative studies have been performed in order to evaluate the magnitude of survival/rehabilitation ratio due to dialysis and transplantation. After a minimum of five years, the overall survival rate is better on dialysis. The most important determining factors seem to be: type of donor in transplantation and the nature of renal lesions and residual Ccr in dialysis. 'True' or 'effective' rehabilitation has been documented only after transplantation. Dialysis does not reverse systemic uraemic changes and the rehabilitation in survivors may be 'apparent'. Dialysis may prevent systemic uraemia, provided that starting time of treatment is gauged earlier (residual Ccr greater than 10).

Disability Evaluation↗